Studi scientifici

2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2026.

· 2026

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

A Review on Diabulimia: Exploring the Intersection of Disordered Eating, Eating Disorders, Insulin Dose Manipulation, and Type 1 Diabetes.

Altabas V, et al. · 2026

INTRODUCTION: Although insulin is essential for managing type 1 diabetes and is life-saving for patients with this condition, some individuals may intentionally reduce or omit insulin due to a fear of…

A scoping review on weight loss injections and eating disorders: therapeutic impact, risks of misuse, and emerging harms.

Barrett P, et al. · 2026

AIM: GLP-1 receptor and GIP agonists are widely used for weight loss in obesity, with strong evidence supporting their efficacy, and their potential positive impact on binge eating disorders. However,…

Activity disruption, illness intrusiveness, and life satisfaction in adults with type 1 diabetes: an ecological momentary assessment study.

Mo Y, et al. · 2026

Illness intrusiveness is a psychological process reflecting the perceived impact of illness-related disruptions on daily life in chronic conditions. Type 1 diabetes (T1D) disrupts daily activities thr…

Addressing micronutrient requirements in type 2 diabetes: an international consensus report.

Xia J, et al. · 2026

Medical nutritional therapy, an evidence-based application of the nutrition care process guided by a registered dietitian nutritionist, is an integral part of diabetes management, with emerging eviden…

Adolescents' experiences of living with type 2 diabetes mellitus: A scoping review.

Peprah Osei E, et al. · 2026

BACKGROUND: Type 2 diabetes mellitus has emerged as a major public health concern among adolescents; however, existing research has largely emphasized biomedical outcomes, with comparatively limited a…

American Association of Clinical Endocrinology Consensus Statement: Algorithm for Management of Adults With Type 2 Diabetes - 2026 Update.

Samson SL, et al. · 2026

OBJECTIVE: This consensus statement provides evidence-based visual guidance in graphic algorithms and a summary of evidence and considerations to assist health care professionals with the diagnosis an…

Association between glycated hemoglobin variability and risk of diabetic kidney disease and diabetic retinopathy in diabetic patients: a systematic review and meta-analysis

Wu Chan, Qin Hanrong, Wei Maoying, Li Aijing, Zhu Qingyi, Guo Jingyi, Sun Anning, Gu Xin et al. · 2026

To provide a scientific basis for the early prevention of diabetic kidney disease and diabetic retinopathy progression in diabetic patients by systematically evaluating the relationship between glycat…

Association between smoking cessation and risk for type 2 diabetes, stratified by post-cessation weight change: A systematic review and meta-analysis.

Yu Y, et al. · 2026

OBJECTIVE: While smoking cessation reduces health risks, its impact on type 2 diabetes mellitus (T2DM) remains complex when considering post-cessation weight gain. This systematic review and meta-anal…

Beneficial effects of berberine in the treatment of diabetes and its complications

Liu Shanyao, Shen Jie, Xu Fanghui, Niu Lu, Wang Fengchan, Zhao Guojing · 2026

Coptis chinensis (Huanglian), a key component in numerous classical Chinese herbal formulas, is traditionally applied for treating metabolic diseases based on its activity including clear heat, dry da…

Beyond weight loss: Integrating GLP-1 RA therapies into psychological and behavioral care for obesity and binge eating disorder.

Mack I, et al. · 2026

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) represent a major advancement in obesity treatment, offering robust efficacy in weight loss and metabolic regulation. Beyond these effects, emergi…

Biological effects of weak magnetic fields: can the radical-pair mechanism provide a universal explanation?

Krylov VV · 2026

The biological effects of weak magnetic fields have long been a subject of scientific inquiry, with increasing evidence supporting their influence on biochemical, physiological, and behavioural proces…

Blood Pressure Levels and Outcomes in Type 2 Diabetes: Dose-Response Meta-Analysis of 5.87 Million Cohort Participants.

Wang S, et al. · 2026

BACKGROUND: The dose-response relationships between systolic and diastolic blood pressure (SBP and DBP) levels and risks of all-cause mortality, cardiovascular and renal outcomes in type 2 diabetes re…

Can the Diabetes Eating Problem Survey-Revised (DEPS-R) reliably identify eating disorder diagnosis in women with type 1 diabetes?

Haugvik S, et al. · 2026

AIMS: The objective of this study was to evaluate the Diabetes Eating Problems Survey-Revised (DEPS-R) against the Eating Disorder Diagnostic Interview (EDDI). Specific aims were to (1) assess the abi…

Carnivore Diet: A Scoping Review of the Current Evidence, Potential Benefits and Risks.

Lietz A, et al. · 2026

Background: The Carnivore Diet (CD) is an almost exclusively animal-based dietary pattern that has gained increasing popularity on social media. Despite numerous health-related claims, a standardized …

Clinical correlation of serum zinc and chromium levels in patients with type 2 diabetes mellitus and complications in Pakistan: a retrospective study

Nayyar Humma, Bhatti Attya, John Peter, Khan Gohar · 2026

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia. The role of trace elements such as zinc and chromium in the pathophysiology of T2…

Consensus Recommendations on Lipohypertrophy: Insights From an International Panel of Experts.

Guo L, et al. · 2026

Lipohypertrophy, characterized by subcutaneous adipose tissue accumulation at sites of insulin administration, affects 29-76% of insulin-treated people with diabetes (PwD), yet remains underrecognized…

Defining and Characterizing Postprandial Reactive Hypoglycemia.

Sweatt SK, et al. · 2026

Objective: Individuals with reactive hypoglycemia (RH) may be more likely to develop obesity and type 2 diabetes, but the ability to identify RH has been hampered by the lack of clear criteria. This s…

Development of the Diabetes Burnout Scale for patients with type 2 diabetes: a modified Delphi study.

Wei Y, et al. · 2026

BACKGROUND: Enhancing diabetes outcomes and delivering patient-centered care hinge on a thorough understanding of diabetes-related burnout. This study aimed to develop an evidence-based, consensus-gui…

Diet, gut microbiome, and type 1 diabetes: from risk to translational opportunity

Girdhar Khyati, Dedrick Sandra, Rhodes Lukas, Kim David, Powis Amaya, Mahon Caitlin, Chapdelaine Hannah, Obaid Liane et al. · 2026

The incidence of type 1 diabetes (T1D) has risen sharply in recent decades, implicating the role of environmental factors in disease pathogenesis. Diet, a primary driver of gut microbiome development …

Direct and Indirect Pathways Between Food Insecurity and Glycemic Control in Adults with Diabetes.

Walker RJ, et al. · 2026

BACKGROUND: Extensive research identifies food insecurity as a driver of poor glycemic control in adults with diabetes. The goal of this study was to investigate the direct and indirect relationships …

Disparities in diabetes treatment and monitoring for people with and without mental disorders: a systematic review and meta-analysis.

Wagner E, et al. · 2026

BACKGROUND: People with mental disorders have an increased risk of diabetes, yet conflicting evidence exists regarding the quality of diabetes care they receive. To address this evidence gap, we condu…

Dose-Escalation Regimens for Incretin Mimetics in Type 2 Diabetes Are Associated With Tolerance for Nausea and Vomiting.

Nauck MA, Punov V, Kang YM, Lim S · 2026

AIMS/HYPOTHESIS: Initial dose-escalation has been shown to mitigate gastrointestinal adverse events in people treated with incretin-based medications. We aimed to analyse dose-response relationships f…

Early meal timing improves nocturnal glucose in pregnancies complicated by gestational diabetes.

Cunningham HA, Ward L, Butler MP, Valent AM · 2026

AIMS/HYPOTHESIS: Gestational diabetes (GDM) results in adverse outcomes for the pregnant individual and neonate. Lifestyle modifications are first-line interventions used to achieve pregnancy-specific…

Eating Disorders in the GLP-1 Era: A Spotlight on Emerging Clinical Risks, Research Gaps, and Practice Priorities.

Škudar S · 2026

OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and related incretin-based medications are rapidly changing the treatment landscape for type 2 diabetes, obesity, cardiovascular risk r…

Effects of a Text Message-Based Lifestyle Intervention on HbA1c and Health Behaviors in Older Adults with Prediabetes

Lee Jung Hun, Kim Hee Jin, Lee Kang Hyun · 2026

Background/Objectives: Prediabetes (PD) does not always progress to type 2 diabetes; however, lifestyle modification and weight loss are recommended to prevent disease progression. This study aimed to…

Effects of intermittent fasting combined with a ketogenic diet versus a hypocaloric diet on metabolic outcomes in adults with type 2 diabetes mellitus: A controlled clinical study.

Barrionuevo-Burgos E, et al. · 2026

BackgroundType 2 diabetes mellitus (T2DM) continues to rise globally, highlighting the need for effective and sustainable dietary strategies. Intermittent fasting (IF) and ketogenic diets have been as…

Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis.

Wu Y, Wang Z, Tuersun A, Yu Q, Zhong Y, Ali SSA, Liu H, Hu X, et al. · 2026

BACKGROUND: Prediabetes refers to the transitional stage from normal glucose metabolism to diabetes. The International Diabetes Federation guidelines reported that, as of 2024, approximately 1.12 bill…

Empagliflozin versus metformin for glucose variability and metabolic outcomes in drug-naïve type 2 diabetes: The EMPA-FIT study.

Lim S, et al. · 2026

AIMS: Sodium-glucose cotransporter-2 (SGLT2) inhibitors offer cardiovascular and renal benefits beyond glycemic control. However, their effect on glucose variability (GV) in drug-naïve individuals wit…

Essential micronutrients and biguanides (metformin) synergistic and antagonistic interactions on neurocognitive outcomes in type two diabetes mellitus: a systematic review of preclinical and clinical evidence

Ninsiima Herbert Izo, Ainamani Herbert E., Ayebazibwe Geoffrey, Matovu Daniel, Eze Ejike Daniel · 2026

Type 2 diabetes mellitus (T2DM) represents a systemic disease that extends beyond metabolic dysfunction to include accelerated neurocognitive decline driven by oxidative stress, inflammation, and insu…

Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies.

Chen A, Zhao K, Ceban F, Nabipoor M, Englesakis M, Chung F, Perlas A · 2026

PURPOSE: Current management of type 2 diabetes mellitus and obesity increasingly includes treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs). In this systematic review and meta-analy…

Glycemic control and association with diabetes-related distress, self-management behavior, financial toxicity, and cost-related non-adherence: a mixed-methods study.

Babaita AO, et al. · 2026

BACKGROUND: The prevalence of diabetes is a growing global health concern. Currently, Nigeria has the highest burden of diabetes in sub-Saharan Africa, and this burden is projected to increase by over…

Immunometabolic reprogramming and β-cell dedifferentiation: Integrated mechanisms driving type 2 diabetes progression.

Dahiya R, et al. · 2026

Type 2 diabetes is increasingly recognised as a condition driven by sustained metabolic overload and chronic low-grade inflammation rather than a simple decline in insulin secretion. Findings from sin…

Impact of Nutritional and Diabetological Education on Glycemic Control and Obstetric and Perinatal Outcomes in Gestational Diabetes Mellitus

Yuste Gómez Alba, Ramos Álvarez Mª del Pilar, Barquiel Beatriz, Bartha José Luis · 2026

Background/Objectives : Gestational diabetes mellitus (GDM) is one of the most common metabolic complications during pregnancy. Nutritional and diabetological education constitutes the cornerstone of …

Impact of exercise sequence in concurrent training on insulin resistance, glycemic control, and blood pressure in Type 2 diabetes.

Amare F, Kiflu A, Taddese A · 2026

This study compared the effects of aerobic followed by resistance (CART) and resistance followed by aerobic (CRAT) training on insulin sensitivity, glycemic control, and blood pressure against a non-e…

Impact of gastric emptying and small intestinal carbohydrate absorption on glycemia in health and diabetes: therapeutic implications.

Jalleh RJ, et al. · 2026

Gastric emptying, which exhibits a substantial interindividual, but much lesser intraindividual, variation in health and is frequently disordered (particularly delayed) in diabetes, is now appreciated…

Implementing Diabetes Eating Problem Survey - Revised in pediatric type 1 diabetes care: Clinician reflections on systematic screening and multidisciplinary management.

Abild CB, et al. · 2026

AIM: Adolescents with type 1 diabetes have an increased risk of disordered eating; however, these symptoms may be underrecognized by clinicians. The aim of this study was to explore clinicians' perspe…

Incretin-Based Therapies for the Treatment of Binge Eating-A Systematic Review.

White RT, et al. · 2026

INTRODUCTION: Binge eating disorder (BED) is a common psychiatric condition associated with psychological and cardiometabolic morbidity. Psychotherapy remains a core treatment modality while pharmacol…

Interactions between nutrition, GLP-1 secretion, and composition of the gut microbiome.

Kouraki A, et al. · 2026

PURPOSE OF REVIEW: Glucagon-like peptide-1 (GLP-1) is a key incretin hormone regulating insulin secretion, appetite, and energy balance. Recent research highlights complex interactions between dietary…

Management of Diabetic Wounds: Expert Panel Consensus Statement.

Hsia HC, et al. · 2026

SIGNIFICANCE: The Wound Healing Foundation recognized the need for consensus-based unbiased recommendations for the treatment of wounds. Consensus statements on the treatment of chronic wounds and acu…

Metformin-Associated Gastrointestinal Intolerance: A Narrative Review of Mechanisms and Clinical Management.

Chen S, et al. · 2026

Metformin-associated gastrointestinal (GI) intolerance is a frequent clinical problem that can limit treatment initiation, delay dose escalation, and reduce long-term adherence in patients with type 2…

Nutrition-induced remission of type 2 diabetes: mechanisms, clinical evidence, and future directions-a mini review

Pescari Denisa, Mihuta Simina, Bena Andreea, Pui Roxana, Paul Corina, Stoian Dana · 2026

Type 2 diabetes mellitus (T2DM) is considered a chronic, progressive and irreversible condition; however, evidence accumulated over the past decade demonstrates that remission of this disease can be a…

Nutritional care using oral nutritional supplements: 22 questions every clinician Asks-Answered by global experts in a Delphi consensus study.

Bahat G, et al. · 2026

BACKGROUND/AIMS: Malnutrition is a common clinical problem causing poor outcomes, including longer hospital stays, complications, functional decline, and mortality. Oral nutritional supplements (ONS) …

Oral health and diabetes: a systematic review and meta-analysis.

Botelho J, et al. · 2026

BACKGROUND: Diabetes is a major public health challenge, affecting nearly 828 million people worldwide. Similarly, oral diseases such as dental caries, periodontal diseases, and oral cancers are highl…

Precision Nutrition in Type 2 Diabetes Prevention Through Molecular Nutrigenomic and Epigenetic Modulation of Insulin Signaling and Glucose Metabolism

Rumui Daniel, Dama Aida, Gorica Era, Halim Victor Samuel, Setiawan Apple Faith, Tjia Xandra Christensen, Hadinata Edwin, Harbuwono Dante Saksono et al. · 2026

Precision nutrition has emerged as a promising strategy for the prevention of type 2 diabetes mellitus (T2DM) by targeting molecular pathways underlying insulin resistance and impaired glucose metabol…

Protocol for a randomized controlled trial comparing saturated and unsaturated fat sources of a ketogenic diet (KETO-IM) investigating cardiovascular, inflammatory and immune function outcomes in adults living with overweight and prediabetes or type 2 diabetes in Edmonton, Canada

Fulton Jodie L., Gartke Trina, Blanco Cervantes Paulina, Mojibi Yasaman, Makarowski Alexander, Richard Caroline, Chan Catherine B. · 2026

Among the general public, the ketogenic (KETO) diet is popular for weight loss and may also support glycemic control in people with type 2 diabetes (T2D). Obesity and T2D have both been associated wit…

Sex differences in the incidence of complications among people with diabetes in a South Indian population: 12 years follow up of CURES study (CURES-159)

Mohan Viswanathan, Rani Coimbatore Subramanian Shanthi, Sankari Ganesan Uma, Pradeepa Rajendra, Unnikrishnan Ranjit, Rahulashankiruthiyayan Thangarajan, Venisha Kumaradas Gini, Geetha Loganathan et al. · 2026

Little data exist on population-based incidence of diabetes related complications in developing countries. We assessed sex-specific incidence of complications among Asian Indians with type 2 diabetes …

Shifts in waist-to-height ratio categories within tirzepatide groups: a post-hoc analysis of SURMOUNT-1.

Sattar N, Tchang BG, Vincent RP, Wang H, Murphy M, Dunn JP, Dimitriadis GK, Fraseur Brumm J, et al. · 2026

OBJECTIVE: To evaluate shifts in waist-to-height ratio (WHtR) categories among adults with obesity or overweight, with or without prediabetes, treated with tirzepatide in the SURMOUNT-1 study. METHODS…

The Association between Psychological Distress and Disordered Eating Behavior in Young People with Type 1 Diabetes: A Systematic Review.

García-Poblet M, et al. · 2026

CONTEXT: Young people with type 1 diabetes mellitus experience unique challenges, including physical and psychological changes, altered nutritional needs, and the risk of weight fluctuations. Psycholo…

The Impact of Macronutrient Ordering on Postprandial Glycaemic Control in Diabetes: A Systematic Review.

McKenzie R, et al. · 2026

AIMS: This systematic review aims to investigate if macronutrient ordering is effective at lowering postprandial glucose excursions in individuals with diabetes. METHODS: A systematic search of Medlin…

The Impact of Metformin on Vitamin B12 Levels in Children and Adolescents: A Systematic Review and Single-Arm Meta-Analysis.

Tahir EA, et al. · 2026

INTRODUCTION: The use of metformin among children and adolescents has risen in the past decade; however, its effect on vitamin B12 has been unclear. To address this gap, we conducted this first system…

The Ketogenic Diet in Type 2 Diabetes and Obesity: A Narrative Review of Clinical Evidence

Kilian Julia, Szlęzak Dominika, Tyszka-Czochara Malgorzata, Filipowicz-Popielarska Elżbieta, Bronowicka-Adamska Patrycja · 2026

Type 2 diabetes mellitus (T2DM) and obesity represent a growing global public health challenge, strongly associated with excess body weight, unhealthy dietary habits, and a sedentary lifestyle. The ke…

The dynamic interrelationships of diabetes distress uncovered by ecological momentary assessment: a systematic review.

Yang S, et al. · 2026

OBJECTIVE: This systematic review aimed to synthesize evidence on the application of Ecological Momentary Assessment (EMA) in dynamically monitoring diabetes distress, and to examine the dynamic assoc…

The ketogenic diet is not for everyone: contraindications, side effects, and drug interactions.

Dyńka D, et al. · 2026

BACKGROUND: The ketogenic diet (KD), initially developed for the treatment of neurological disorders, has gained increasing attention for its potential role in the management of various metabolic dise…

The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications.

Jalleh RJ, Talley NJ, Horowitz M, Nauck MA · 2026

GLP-1 receptor agonist (GLP-1RA) medications have transformed the treatment of type 2 diabetes (T2D) and obesity, with robust evidence for cardiovascular and renal benefits. Nevertheless, GLP-1RA ther…

Understanding the Periodontitis-Diabetes Linkage: Mechanisms and Evidence.

Graves DT, et al. · 2026

Diabetes mellitus (DM) and periodontitis share a complex, bidirectional relationship, with each condition exacerbating the other. Diabetes, particularly when poorly controlled, significantly increases…

Worldwide prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes: A systematic review and meta-analysis.

Zhang T, et al. · 2026

OBJECTIVE: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D) and a marker of delayed diagnosis, associated with significant morbidity, mortality, and healthcare c…

β-hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Ding Xianyi, Wu Jiabin, Wang Lian, Li Ke, Gao Haoyang, Wu Mingyu, Zhang Qiuyu, Han Ruonan et al. · 2026

Type 2 diabetes mellitus (T2DM) is a major metabolic disease that poses a threat to human health; therefore, the development of new pharmaceutical therapies for the treatment of T2DM is of great impor…

14. Children and Adolescents: Standards of Care in Diabetes-2025.

· 2025

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2025.

· 2025

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025.

· 2025

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2025.

· 2025

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

A Narrative Review of the Interplay Between Carbohydrate Intake and Diabetes Medications: Unexplored Connections and Clinical Implications

Mphasha Mabitsela Hezekiel, Vagiri Rajesh · 2025

This narrative review examines the dynamic interplay between carbohydrate intake and diabetes medications, highlighting their combined molecular and clinical effects on glycemic control. Carbohydrates…

A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise.

Richter EA, et al. · 2025

Skeletal muscle is the main site of glucose deposition in the body during meals and the major glucose utilizer during physical activity. Although in both instances the supply of glucose from the circu…

A parallel-group controlled clinical study to evaluate the efficacy of self-family-environment empowerment diet management intervention in improving outcomes for pregnant women with gestational diabetes mellitus

Jing Ji, Liu Yina · 2025

Gestational diabetes mellitus (GDM) is a serious health problem that poses threats to both mothers and babies, thus leading to the intensive need for management. The current study examined how the SFE…

A qualitative study of the mental health outcomes in people being treated for obesity and type 2 diabetes with glucagon-like peptide-1 receptor agonists.

Pierret ACS, et al. · 2025

OBJECTIVE: Obesity and type 2 diabetes (T2D) are associated with increased rates of mental disorders, particularly depression, anxiety and binge-eating disorder. GLP-1 receptor agonists are a novel cl…

A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults.

McGowan B, et al. · 2025

This systematic review and network meta-analysis evaluated the efficacy and safety of obesity management medications (OMMs) in terms of reducing body weight and impact on obesity-related complications…

Absolute quantitative metagenomic analysis reveals unique gut bacteria underlying berberine and metformin’s anti-metabolic disorders effects

Zhan Jiaguo, Cheng Bin, Guo Kangmiao, Tao Xueqing, Cai Xinyan, Li Zhuoran, Tang Zhenhao, Zhan Jingke et al. · 2025

This study aimed to evaluate the potential functional bacteria in the efficacy of two drugs in ameliorating diet-induced metabolic disorder model using absolute and relative quantification methods and…

Adherence to Personalised Nutrition Education Based on Glycemic and Food Insulin Index Principles and Their Association with Blood Glucose Control in Individuals with Type 2 Diabetes Mellitus

Strydom Hildegard, Muchiri Jane, Delport Elizabeth, White Zelda · 2025

Personalised nutrition education (PNE) can enhance blood glucose control (BGC). We determined whether patients with type 2 diabetes (T2DM) adhered to PNE based on glycemic index (GI), glycemic load (G…

Advance Insulin Injection Technique and Education With FITTER Forward Expert Recommendations.

Klonoff DC, et al. · 2025

Injectable insulin therapy is a valuable therapeutic option for millions of people with diabetes worldwide. However, many people with diabetes undergoing insulin therapy experience suboptimal outcomes…

Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut.

Zhang Y, et al. · 2025

Akkermansia muciniphila is a promising target for managing obesity and type 2 diabetes (T2D), but human studies are limited. We conducted a 12-week randomized, double-blind, placebo-controlled trial i…

An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial.

Mathioudakis N, et al. · 2025

IMPORTANCE: Prediabetes is common, yet evidence-based lifestyle interventions are underutilized. OBJECTIVE: To determine whether referral to an exclusively artificial intelligence (AI)-led lifestyle i…

Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank

Cheng Zi-Jian, Luo Yu-feng, Zhu Qing-yun, Wang Yan-fei, Ren Wen-yan, Deng Fei-yan, Bo Lin, Jiang Xi-Yuan et al. · 2025

Glucosamine is a widely used supplement for treating osteoarthritis and joint pain. New evidence suggests a potential association between glucosamine and type 2 diabetes, inflammation and cardiometabo…

Association of sucralose consumption with insulin response and sensitivity.

Kodumayil S, et al. · 2025

BACKGROUND AND AIM: Use of non-nutritive sweeteners (NNS) is widespread in foods and beverages and are believed to have little to no impact on glucose metabolism. Nonetheless, recent studies have show…

Attention-Deficit/Hyperactivity Disorder Symptoms Are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes.

Zhang-James Y, et al. · 2025

Objective: to assess the association between attention-deficit/hyperactivity disorder (ADHD), type 1 diabetes mellitus (T1D), and cardiovascular comorbidities in adults. Methods: The Adult Self-Report…

Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial.

Ji L, et al. · 2025

IMPORTANCE: Few of the available therapies for type 2 diabetes (T2D) comprehensively address disease burden beyond glycemic control. Examining whether berberine ursodeoxycholate (HTD1801), a first-in-…

Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence

Kong Yue, Yang Haokun, Nie Rong, Zhang Xuxiang, Zhang Hongtao, Nian Xin · 2025

Obesity, clinically defined by pathological adipose tissue accumulation disrupting metabolic homeostasis, has reached pandemic proportions. The World Obesity Atlas 2024 reports over 1.5 billion projec…

Beyond Weight Loss: GLP-1 Usage and Appetite Regulation in the Context of Eating Disorders and Psychosocial Processes.

Krug I, et al. · 2025

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed treatment for higher weight and diabetes. Because they also influence appetite and reward processes, these medications…

Birth Weight, Cardiovascular Health, and Microvascular Complications in Individuals with Diabetes Mellitus

Yu Chaolun, Feng Anping, Zou Xia, Chen Siqi, Dai Lingyan, Cui Qingmei, Kuang Xiaojing, She Gaoli et al. · 2025

Diabetes often leads to microvascular complications, including nephropathy, neuropathy, and retinopathy. Understanding the impact of early-life factors like birth weight and modifiable behaviors such …

Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight.

Look M, Dunn JP, Kushner RF, Cao D, Harris C, Gibble TH, Stefanski A, Griffin R, et al. · 2025

AIMS: We assessed changes in body composition following tirzepatide treatment in a substudy of participants with obesity or overweight from the SURMOUNT-1 trial, overall and post hoc in clinically rel…

Burden of micronutrient deficiency among patients with type 2 diabetes: systematic review and meta-analysis.

Mangal DK, et al. · 2025

BACKGROUND: Micronutrient deficiencies are a significant issue worldwide, particularly in South Asia and sub-Saharan Africa. These deficiencies can impact glucose metabolism and insulin signalling pat…

Can Glucose Alarm Fatigue Threaten the Absolute Clinical Benefit of Continuous Glucose Monitoring in Optimal Glucose Management in Children and Adolescents with Type 1 Diabetes? A Narrative Review.

Giza S, et al. · 2025

Technology has brought about a revolution in the management of type 1 diabetes (T1D). The adoption of continuous glucose monitoring (CGM) and insulin pump therapy in the everyday life of children and …

Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes

Ferdowsi Parisa Vahidi, Ahuja Kiran D. K., Beckett Jeffrey M., Myers Stephen · 2025

The global burden of type 2 diabetes (T2DM) has led to significant interest in finding novel and effective therapeutic targets for this chronic disorder. Bioactive food components have effectively imp…

Carbohydrates-Last Food Order Improves Time in Range and Reduces Glycemic Variability.

Touhamy S, et al. · 2025

Perche' lo studio esiste: gli studi precedenti sull'ordine dei cibi avevano misurato l'effetto su UN pasto in laboratorio. Restava la domanda che conta davvero per chi vive col diabete: se mangi cosi'…

Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes.

Nicholls SJ, et al. · 2025

BACKGROUND: Tirzepatide, a dual incretin agonist of the glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, has favorable effects on glycemic control and body weight. T…

Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study

Yang Bo, Yao Bo, Zou Qu, Li Sicheng, Yang Shun, Yang Mengxue · 2025

Background: It remains unclear whether cholesterol-lowering therapy can reduce the incidence of microvascular complications in patients with diabetes. We aim to explore the potential causal relationsh…

Comparative efficacy of dietary interventions for glycemic control and pregnancy outcomes in gestational diabetes: a network meta-analysis of randomized controlled trials

Di Jiaoyang, Fan Jingjing, Ma Fangxu · 2025

Gestational diabetes mellitus (GDM) poses significant risks to both maternal and fetal health, and effective dietary interventions are critical for managing the condition. This study aimed to evaluate…

Comparison of perinatal outcomes of women with gestational diabetes mellitus according to type of treatment for glycemic control

de Souza Pollyana Carvalho, da Silva Amanda Gabriela Araújo, Santos Cristina Maria de Araújo Medeiros, Santiago Luciana Araújo Cartaxo da Costa, Araújo Maria Elionês de Oliveira, de Lima Isabelle Lorena Barbosa, Ribeiro Karla Danielly da Silva · 2025

To compare the perinatal outcomes of women with Gestational Diabetes Mellitus (GDM), between pregnant treated only with lifestyle changes and pregnant treated with insulin and lifestyle changes. Prosp…

Consumption of Fruit Juice and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

Lee CW, et al. · 2025

BACKGROUND: Previous observational studies on the association between the consumption of fruit juice and the risk of type 2 diabetes mellitus have reported inconsistent findings. We investigated the a…

Continuous glucose monitoring in type 2 diabetes: a systematic review of barriers and opportunities for care improvement.

Barchiesi MA, et al. · 2025

BACKGROUND: Diabetes mellitus, particularly type 2 diabetes (T2DM), is a chronic disease associated with serious complications, such as heart disease, kidney failure, and blindness. Continuous glucose…

Contraception and Diabetes Mellitus.

Panou T, et al. · 2025

The aim of this narrative review was to discuss data on contraception in diabetes mellitus (DM). Women with DM rarely discuss contraception with their physicians, and healthcare providers offer advice…

Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women

Yiğiter Nuray, Akçınar Faruk, Yasul Yavuz, Çınar Vedat, Akbulut Taner, Migliaccio Gian Mario · 2025

Background and Objectives : Prediabetes (PD) is characterized by impaired glucose metabolism and is associated with an elevated risk of type 2 diabetes and cardiovascular diseases. This study aimed to…

Correlation between blood cell indices and adiponectin and leptin levels in COVID-19

Manojlovic Mia, Ilincic Branislava, Bojovic Marko, Kolarski Ivor, Naglic Dragana Tomic, Stokic Edita, Zafirovic Sonja, R Isenovic Esma · 2025

Adipose tissue (AT) is a major metabolic organ, functioning through autocrine, paracrine, and endocrine mechanisms. This study investigated the relationship between adipokine levels and blood cell ind…

DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial.

Fang M, et al. · 2025

The Dietary Approaches to Stop Hypertension (DASH) diet is rich in foods (fruits, vegetables, whole grains) that may reduce hyperglycemia and glycemic variability. In this randomized crossover feeding…

Dapagliflozin plus calorie restriction for remission of type 2 diabetes: multicentre, double blind, randomised, placebo controlled trial.

Liu Y, et al. · 2025

OBJECTIVE: To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes. DESIGN: Multicentre, double blind, randomised, placebo controlled trial. SETTING: 16 centres …

Development of a Meal-Planning Exchange List for Traditional Sweets and Appetizers in Gulf Cooperation Council Countries: Insights from Qatar

Abdul Majeed Safa, Tayyem Reema · 2025

Background & Aim: Sweets and appetizers are an integral part of the Gulf Cooperation Council (GCC) region’s cultural heritage but are often high in refined carbohydrates, sugars, and fats, contributin…

Development of the TBQ+D: A Novel Patient-Reported Measure of The Burden of Digital Care.

Al Zahidy M, et al. · 2025

BACKGROUND: Patients with diabetes manage complex treatment regimens that include the use of digital medicine tools. Existing instruments do not explicitly capture treatment burden, i.e., workload and…

Diabetes Deprescribing in Older Adults: A Randomized Clinical Trial.

Grant RW, et al. · 2025

IMPORTANCE: Medication-related hypoglycemia is the leading cause of iatrogenic complications among older adults with type 2 diabetes. OBJECTIVE: To compare physician academic detailing (AD) with or wi…

Diabetes-Related Extremity Amputation Depression and Distress (DREADD): A Multimethod Study.

Brooks LM, et al. · 2025

Of the roughly 38 million people diagnosed with type 2 diabetes mellitus in the United States, up to 34% will develop a diabetic foot ulcer at some point, up to 75% of those who develop an ulcer will …

Diagnosis and Phenotypes of Idiopathic Diabetes: A Systematic Review.

El Nahas R, et al. · 2025

OBJECTIVE: Diabetes classification includes various forms, primarily type 1 and type 2, along with atypical types like type-1b diabetes (T1bD), which lack classic autoimmune markers or high-risk human…

Dietary Interventions for Adults with Type 1 Diabetes: Clinical Outcomes, Guideline Alignment, and Research Gaps—A Scoping Review

Sperkowska Beata Małgorzata, Chrustek Agnieszka, Gryn-Rynko Anna, Proszowska Anna · 2025

Background/Objectives: Medical nutrition therapy (MNT) is a crucial component of type 1 diabetes (T1D) management; however, the effectiveness of specific dietary approaches in adults remains unclear d…

Dietary Modification with Food Order and Divided Carbohydrate Intake Improves Glycemic Excursions in Healthy Young Women.

Higuchi Y, Miyawaki T, Kajiyama S, Kitta K, Kajiyama S, Hashimoto Y, Fukui M, Imai S, et al. · 2025

Background/Objectives: Previous studies show that allocating carbohydrates earlier and vegetables/protein later in late-evening meals improves glycemic control in both healthy individuals and those wi…

Dietary Sugar Intake and Incident Type 2 Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.

Della Corte KA, et al. · 2025

The dose-response relationship between dietary sugar and type 2 diabetes (T2D) risk is uncertain. MEDLINE, Embase, CINAHL, Web of Science and Cochrane databases were searched through July 9, 2024 for …

Distinguishing risk factors for depression and burnout in parents managing type 1 diabetes mellitus in children.

Vayisoglu SK, et al. · 2025

PURPOSE: Identifying factors affecting the mental health of parents with children diagnosed with type 1 diabetes mellitus is crucial in the caregiving process. The aim of this study was to determine t…

Dysregulation of the FGF21–Adiponectin Axis in a Large Cohort of Patients with Severe Obesity and Liver Disease

Castañé Helena, Jiménez-Franco Andrea, Onoiu Alina-Iuliana, Cambra-Cortés Vicente, Hernández-Aguilera Anna, Parada David, Riu Francesc, Zorzano Antonio et al. · 2025

We investigated the impact of liver damage on systemic inter-organ communication in an extensive observational case–control study of 923 patients with severe obesity and biopsy-confirmed metabolic dys…

Effect of long-term Mediterranean versus low-fat diet on neutrophil count, and type 2 diabetes mellitus remission in patients with coronary heart disease: results from the CORDIOPREV study

Boughanem Hatim, Gutierrez-Mariscal Francisco M., Arenas-de Larriva Antonio Pablo, Torres-Peña José D., Romero-Cabrera Juan L., Rangel-Zuñiga Oriol Alberto, García-Fernández Helena, Podadera-Herreros Alicia et al. · 2025

Recent evidence links diet and physical activity with type 2 diabetes mellitus (T2DM) remission, but emerging findings suggest that immune system dysregulation may play a crucial role. This study aime…

Effect of nine different exercise interventions on insulin sensitivity in diabetic patients: a systematic review and mesh meta-analysis

Pan Yikang, Wang Peng, Yue Chunlin, Liu Chen · 2025

This study aimed to assess the impact of nine exercise interventions (resistance training [BT, ball training [BT], resistance + walking [RT+W alk], resistance + running [RT + Running], resistance + cy…

Effect of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in gestational diabetes patients undergoing dietary therapy

Yu Shiwen, Yu Xiaolin, Li Furong · 2025

This study aims to evaluate the effects of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM) undergoing di…

Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial.

Muthukuda D, de Silva CK, Ajanthan S, Wijesinghe N, Dahanayaka A, Pathmeswaran A · 2025

BACKGROUND: Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately mea…

Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Li Y, et al. · 2025

BACKGROUND: Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant that has been suggested to have beneficial effects on lipid profiles and blood pressure. This systematic review and meta-analysis …

Effects of Cognitive Behavioral Therapy for Diet on Postprandial Glucose and Pregnancy Outcomes in Gestational Diabetes Mellitus: Multicenter Randomized Controlled Trial

Pan Ying, Tang Jia, Lu Bing, Kuang Ming, Zhao Mengjie, Liu Hongying, Zhong Shao · 2025

Gestational diabetes mellitus (GDM) is associated with an elevated risk of adverse maternal and neonatal outcomes. Dietary management is a cornerstone of GDM treatment due to its beneficial effects on…

Effects of Lifestyle Interventions to Promote Physical Activity on Physical Activity and Glycated Hemoglobin in Patients with Type 2 Diabetes: a Systematic Review and Meta-Analysis

Hohberg Vivien, Lichtenstein Eric, Kreppke Jan-Niklas, Zanitti Cedrine, Streckmann Fiona, Gerber Markus, Faude Oliver · 2025

Numerous studies have explored the impact of controlled exercise interventions in type 2 diabetes, as physical activity can positively influence its progression. However, our understanding of how broa…

Effects of acute exercise or short-term exercise interventions on metabolic markers during experimentally-induced sleep loss in humans: A systematic literature review

Faria Vinicius S., McManus Laura, O’Hagan Anna Donnla, Egan Brendan · 2025

A systematic search was conducted for studies that compared glucose and insulin concentrations, insulin sensitivity, skeletal muscle gene expression, and other molecular markers followed by an acute o…

Effects of apple cider vinegar on glycemic control and insulin sensitivity in patients with type 2 diabetes: A GRADE-assessed systematic review and dose-response meta-analysis of controlled clinical trials.

Arjmandfard D, et al. · 2025

BACKGROUND AND AIMS: Diabetes mellitus (DM) is a multifactorial metabolic disorder that affects the body's ability to regulate blood sugar levels. Apple cider vinegar (ACV) could possibly improve diab…

Effects of blenderized watermelon consumption on satiety and postprandial glucose in overweight and obese adolescents.

Rasmussen C, et al. · 2025

BACKGROUND: Watermelon and its rind are rich in fiber, vitamins, minerals, and L-citrulline. Despite these nutritional benefits, research on the effects of blenderized watermelon (WM), especially in a…

Effects of endurance exercise training on endoplasmic reticulum stress in pancreatic islets of obese mice

Marconato-Júnior E., Soares G.M., Rodrigues-dos-Santos K., Araujo T. dos Reis, Vettorazzi J.F., Zangerolamo L., Costa-Junior J.M., Carneiro E.M. et al. · 2025

Obesity is a serious health problem worldwide and the search for new control methods and therapies is imperative. Studies indicate that a variety of obesogenic diets may increase the risk of developin…

Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells

Krassovskaia Polina, Jevtovic Filip, Zheng Donghai, Noone John, Yeo Reichelle X., Pino Maria F., Stowe Cynthia L., Emilson Shannon S. et al. · 2025

Endurance‐oriented exercise typically enhances insulin action in skeletal muscle; however, relatively little is known about the impact of resistance exercise. In the present study, insulin action was …

Effects of transtheoretical model-based cognitive load dietary education on glycemic control and pregnancy outcomes in gestational diabetes mellitus: A retrospective propensity score-matched study

Cao Hongxia, Wu Yingchun · 2025

This study aimed to evaluate the association between a dietary education approach grounded in the transtheoretical model and cognitive load theory and glycemic control and pregnancy-related outcomes i…

Efficacy and Safety of GLP-1 RAs in Children and Adolescents With Obesity or Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Kotecha P, et al. · 2025

IMPORTANCE: Obesity affects 1 in 5 children and adolescents, increasing the risk of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the few pharmacotherapy optio…

Endoscopic sleeve gastroplasty (ESG): indications and results-a systematic review.

Stier CK, et al. · 2025

Obesity is a major global health problem and at the same time a financial burden for social security systems. For a long time, conventional lifestyle interventions have tried unsuccessfully to find a …

Environmental Insults to Glucose Metabolism: The Role of Pollutants in Insulin Resistance

Młynarska Ewelina, Grabarczyk Mikołaj, Leszto Klaudia, Luba Gabriela, Motor Jakub, Sosińska Aleksandra, Rysz Jacek, Franczyk Beata · 2025

Insulin resistance is a condition of impaired tissue reactivity to insulin. This state is primarily associated with obesity and the lifestyle of modern Western societies, which favors abnormalities of…

Environmental Mechanisms Influencing the Pathogenesis and Progression of Type 1 Diabetes

Tang Yuntao, Wang Weizhou, Huang Zhengsha, Zhang Chenxi, Zhang Jia, Pang Yafang, Li Shangze · 2025

Type 1 diabetes (T1D) is a complex autoimmune disorder characterized by the selective destruction of insulin-producing pancreatic β-cells. While genetic predisposition establishes susceptibility, envi…

Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults in the ARIC Study.

Abushamat LA, et al. · 2025

BACKGROUND: Circulating erythritol, an endogenously produced metabolite and an artificial sweetener, is associated with cardiovascular outcomes. OBJECTIVES: The authors assessed associations of erythr…

Evaluation of the Impact of Mobile Health App Vitadio in Patients With Type 2 Diabetes: Randomized Controlled Trial.

Bretschneider MP, et al. · 2025

BACKGROUND: Effective diabetes management requires a multimodal approach involving lifestyle changes, pharmacological treatment, and continuous patient education. Self-management demands can be overwh…

Exploring the social experiences, stigma and discrimination, faced by women with gestational diabetes: A collaborative qualitative study and item-pool development.

Holmes-Truscott E, et al. · 2025

AIM: To explore experiences of stigma related to gestational diabetes (GDM) among Australian women and collaboratively develop a comprehensive item pool to assess experienced and internalised GDM-spec…

Fasting elicits gut microbiome signature changes that extend to type 1 diabetes patients

Graef Franziska A., Berger Bettina, Bahr Lina S., Stange Rainer, Michalsen Andreas, Paul Friedemann, Vallance Bruce A., Jacobson Kevan · 2025

The gut microbiome has been linked to the pathogenesis of type 1 diabetes (T1D), identifying it as a promising therapeutic target. Nutritional interventions, which are an effective way to modulate the…

Financial Toxicity in Diabetes: The State of What We Know.

Patel MR · 2025

PURPOSE OF REVIEW: This systematic examination quantifies financial toxicity- the economic burden and related financial distress experienced by patients due to medical costs- in diabetes management gl…

Gestational diabetes and mental health: longitudinal analysis of data from the GEMS randomized trial.

Ohene-Agyei P, et al. · 2025

PURPOSE: There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and h…

Glycemic Management in Adults With Diabetes During Illness.

Yuang K, et al. · 2025

Optimal management of hyperglycemia during illness has been hindered by a lack of comprehensive sick-day guidance, particularly for adults with diabetes. Managing glycemia can be challenging during il…

Glycemic and Insulinemic Index Values of Apple Puree.

Lecerf JM, et al. · 2025

A low glycemic index is known to have numerous health benefits, especially in the prevention of metabolic diseases as type 2 diabetes. The glycemic response following specific foods consumption has be…

Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study

Al-Daghri Nasser M., Yakout Sobhy M., Hussain Syed Danish, Alnaami Abdullah M., Veronese Nicola, Barbagallo Mario, Sabico Shaun · 2025

This study investigates the prevalence of hypomagnesemia in adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia, and examines its association with various metabolic parameters. Conduct…

Impact of Meal Insulin Bolus Timing and Bedtime Snacking on Continuous Glucose Monitoring-Derived Glycemic Metrics in Hospitalized Inpatients.

Alexanian SM, et al. · 2025

Objective: In hospitalized inpatients, timely administration of prandial insulin with meals is challenging. Furthermore, the glycemic impact of snacking after dinner ("bedtime snacking") without prand…

Impact of nutrition counseling on dietary improvements, glycemic control, and neonatal outcomes in pregnant women with pregestational diabetes mellitus: an electronic medical charts analysis study in a tertiary medical center

Wang Ya-Ling, Chen Chiao-Ming, Chung Chia-Chun, Chen Wei-Chen, Liao Jui-Hua, Yang Wen-Ching, Su Hsiu-Wei, Chiang Xin-Yu et al. · 2025

Pregnant women with pregestational diabetes mellitus (PDM) are at higher risk of adverse maternal and neonatal outcomes, including preterm birth and macrosomia. Nutrition counseling plays a critical r…

Impact of zinc and chromium deficiency on gene expression in type 2 diabetes mellitus

Nayyar Humma, Bhatti Attya, John Peter · 2025

The increasing prevalence of type 2 diabetes mellitus (T2DM), largely attributable to poor dietary habits and nutritional imbalances, highlights the need for novel diagnostic and therapeutic approache…

In-Hospital Diabetes Management by a Diabetes Team and Insulin Titration Algorithms Based on Continuous Glucose Monitoring or Point-of-Care Glucose Testing in Patients With Type 2 Diabetes (DIATEC): A Randomized Controlled Trial.

Olsen MT, et al. · 2025

OBJECTIVE: The Diabetes Team and CGM in Managing Hospitalized Patients With Diabetes (DIATEC) trial investigates the glycemic and clinical effects of inpatient continuous glucose monitoring (CGM)-guid…

Insulin Rationing Persists Despite Policy Changes: Repeated Cross-Sectional Studies, 2017 vs 2024.

Khan S, et al. · 2025

BACKGROUND: Insulin is a life-saving medication for people with diabetes, but access barriers, such as high costs, can result in rationing. Multiple policies have been introduced to limit insulin out-…

International expert consensus on surgery for type 2 diabetes mellitus.

Kermansaravi M, et al. · 2025

INTRODUCTION: Metabolic and bariatric surgery (MBS) has been an established treatment option for patients with Type 2 diabetes mellitus (T2DM), but there is a relative paucity of evidence-based guidel…

Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity.

Omary L, et al. · 2025

Type 2 diabetes and obesity have become major public health concerns. Growing evidence suggests that increased dietary fiber intake, through its interaction with the gut microbiota, may help prevent t…

Leptin and Acute Lung Disorders

Huertas Alice, Bhattacharya Jahar · 2025

Leptin, an adipokine primarily produced in white adipose tissue, plays a crucial role in metabolism, immunity, and inflammation. Originally identified as a satiety hormone, leptin is also synthesized …

Long-Term Efficacy and Safety of a Low-Carbohydrate Diet in Type 2 Diabetes Remission: A Systematic Review

Das Rajib, Mohammad Nour, Islam Md Shaiful, Das Sowmitra, Abdullah Faisal, Kader Md. Abdul, Mamun Md Abdullah Al, Dutta Sourav et al. · 2025

Type 2 diabetes mellitus (T2DM) is a major global health concern with increasing prevalence and healthcare costs. Despite the availability of pharmacological interventions, sustained glycemic control …

Low-Carb and Ketogenic Diets in Type 1 Diabetes: Efficacy and Safety Concerns

Korakas Emmanouil, Kountouri Aikaterini, Petrovski Goran, Lambadiari Vaia · 2025

Despite advances in technology, the overall management of type 1 diabetes mellitus (T1DM) remains suboptimal. The idea of restricting carbohydrate intake to decrease glycemic spikes and insulin requir…

Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies.

Liu B, et al. · 2025

OBJECTIVE: To prospectively examine associations between five low-carbohydrate diets (LCDs), differentiated by macronutrient quality, and type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS: This …

Medically Tailored Grocery Delivery for Food Pantry Clients with Diabetes.

Short E, et al. · 2025

OBJECTIVE: To determine the impact of a home-delivered, medically tailored grocery intervention on glycemic control and diet quality among participants with type 2 diabetes (T2D) experiencing food ins…

Meta-Analysis: Global Prevalence of Coeliac Disease in Type 1 Diabetes.

Karimzadhagh S, et al. · 2025

BACKGROUND: Coeliac disease (CD) is common in patients with type 1 diabetes (T1D), but prevalence varies globally due to differing screening protocols. There have been substantial changes in screening…

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People With Diabetes: The Need for Screening and Early Intervention. A Consensus Report of the American Diabetes Association.

Cusi K, et al. · 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), is a growing but often unrecognized medical problem for people with …

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

Sebo Zachary L., Chakrabarty Ram P., Grant Rogan A., D’Alessandro Karis B., Koss Alec R., Blum Jenna L. E., Davidson Shawn M., Reczek Colleen R. et al. · 2025

Metformin is a therapeutically versatile biguanide drug primarily prescribed for type II diabetes. Despite its extensive use, the mechanisms underlying many of its clinical effects, including attenuat…

MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

Alcala-Diaz Juan Francisco, Camargo Antonio, Vals-Delgado Cristina, Leon-Acuña Ana, Garcia-Fernandez Helena, Arenas-de Larriva Antonio P., Perez-Cardelo Magdalena, Mora-Ortiz Marina et al. · 2025

Type 2 diabetes mellitus (T2DM) is currently a major global public health problem. Although disease remission is possible, few biomarkers have been identified which can help us select the diet that be…

Modulation of lipid metabolism by exercise: exploring its potential as a therapeutic target in cancer endocrinology

Liu Haodong, Yang Tong, Choi Seongbeom · 2025

Cancer progression is tightly linked to metabolic changes, particularly in lipid metabolism, which is crucial for tumor growth and metastasis. Exercise, known for its health benefits, is gaining recog…

Myths and Facts Regarding Low-Carbohydrate Diets.

Teicholz N, et al. · 2025

As the prevalence of chronic diseases persists at epidemic proportions, health practitioners face ongoing challenges in providing effective lifestyle treatments for their patients. Even for those pati…

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.

Chakravartti SP, et al. · 2025

Sucralose, a widely used non-caloric sweetener, provides sweet taste without calories. Some studies suggest that non-caloric sweeteners stimulate appetite, possibly owing to the delivery of a sweet ta…

Nutrients and Natural Substances for Hypoglycemic Effects and Management in Diabetic Retinopathy

Cappellani Francesco, Foti Roberta, Malaguarnera Giulia, D’Esposito Fabiana, Musumeci Carlo, Rapisarda Lorenzo, Tognetto Daniele, Gagliano Caterina et al. · 2025

Diabetic retinopathy (DR) is a significant microvascular consequence of diabetes mellitus (DM), resulting in visual impairment and blindness. Controlling hyperglycemia is essential for avoiding and al…

Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort

Kennedy Elaine Catherine, Ross Fiona Catherine, O’Shea Carol-Anne, Lavelle Aonghus, Ross Paul, Dempsey Eugene, Stanton Catherine, Hawkes Colin Patrick · 2025

Type 1 diabetes (T1D) is an autoimmune-mediated disorder caused by the destruction of pancreatic beta cells. Although there is an underlying genetic predisposition to developing T1D, the trigger is mu…

Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial.

Rademaker D, et al. · 2025

IMPORTANCE: Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinata…

Overview of Metformin and Neurodegeneration: A Comprehensive Review

Kruczkowska Weronika, Gałęziewska Julia, Buczek Paulina, Płuciennik Elżbieta, Kciuk Mateusz, Śliwińska Agnieszka · 2025

This comprehensive review examines the therapeutic potential of metformin, a well-established diabetes medication, in treating neurodegenerative disorders. Originally used as a first-line treatment fo…

Partially Hydrolyzed Guar Gum Combined with a Low-Fat Diet Ameliorates Type 2 Diabetes Mellitus via Modulating Gut Microbiota and Fecal Metabolites

Cao Zhiqiang, Li Hongxia, Cai Quantao, Chen Li, Liu Liangzhong, Tang Yuhan, Zhu Zhe, Yao Ping · 2025

Background : Low-fat diet (LFD) is widely applied in type 2 diabetes mellitus (T2DM), but the limited efficacy and difficulty in maintaining it hinder its wider promotion. Partially hydrolyzed guar gu…

Personalised Nutrition Approaches in the Prevention and Management of Type 2 Diabetes: A Narrative Review of Evidence and Practice

Mphasha Mabitsela, Mothiba Tebogo · 2025

Type 2 diabetes mellitus (T2DM) remains a significant global public health concern, largely driven by poor dietary habits, physical inactivity, and rising obesity rates. In recent years, personalised …

Pharmacotherapy for obesity management in adults: 2025 clinical practice guideline update.

Pedersen SD, et al. · 2025

BACKGROUND: Pharmacotherapy is a key component of comprehensive obesity management, alongside behavioural therapy and metabolic and bariatric surgery. In this guideline, we update the pharmacotherapy …

Prevention of type 2 diabetes through prediabetes remission without weight loss.

Sandforth A, et al. · 2025

Clinical practice guidelines recommend defined weight loss goals for the prevention of type 2 diabetes (T2D) in those individuals with increased risk, such as prediabetes. However, achieving prediabet…

Protective Effects of PACAP in Diabetic Complications: Retinopathy, Nephropathy and Neuropathy

Reglodi Dora, Tamas Andrea, Bosnyak Inez, Atlasz Tamas, Szabo Edina, Li Lina, Horvath Gabriella, Opper Balazs et al. · 2025

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide exerting, among others, strong trophic and protective effects. It plays a role in several physiological functions, includin…

Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats

Liu Yu, Hussain Shaik Althaf, Yue Hua · 2025

Berberine, known as an antioxidant agent, can improve glycemic indices in animal models of diabetes; however, it is clinically limited by poor bioavailability. Nanoparticles show the desirable capacit…

Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial

Kusinski Laura C., Jones Danielle, Atta Nooria, Turner Elizabeth, Smith Suzanne, Oude Griep Linda M., Rennie Kirsten, De Lucia Rolfe Emanuella et al. · 2025

Reduced-energy diets promote weight loss and improve long-term outcomes in type 2 diabetes but are untested in gestational diabetes. We aimed to identify if weight loss in pregnancy improves perinatal…

Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective

Łukowski Wojciech · 2025

Type 1 diabetes (T1D) has long been recognized as a T-cell-driven autoimmune disease. However, growing evidence highlights the involvement of metabolic, inflammatory, and gut microbiota-related factor…

Registered clinical trials targeting type 2 diabetes remission with pharmacological interventions.

Shoung N, et al. · 2025

Systematic reviews and meta-analyses indicate that dietary interventions and metabolic surgery lead to higher rates of type 2 diabetes (T2D) remission, improving beta-cell function and insulin sensiti…

Relationship Between Improvements in Glycemic Control and Risk of Pregnancy Complications in Patients With Diabetes Mellitus: Metaregression Analysis of Randomized Controlled Trials of Intensive Glucose Management

Kodama Satoru, Fujihara Kazuya, Yagyuda Noriko, Yachi Yoko, Horikawa Chika, Takeda Yasunaga, Morikawa Sakiko Yoshizawa, Yamada Takaho et al. · 2025

Background: It remains unknown whether improvements in prognosis of pregnancy in patients with diabetes mellitus are dependent on glycemic control (GC). This metaregression analysis was aimed at explo…

Self-efficacy, diabetes distress, self-management, and glycemic regulation: within-person pathways in type 1 diabetes.

Gonzalez JS, et al. · 2025

BACKGROUND: Despite extensive research on the role of self-efficacy in behavioral performance across various domains, its specific influence on self-management behaviors in type 1 diabetes (T1D) remai…

Semaglutide in Adults with Type 1 Diabetes and Obesity.

Shah VN, et al. · 2025

BACKGROUND: Once-weekly semaglutide is approved for the management of type 2 diabetes and obesity. The efficacy and safety of semaglutide in adults with type 1 diabetes are not established. METHODS: I…

Short and long-term side effects of the Classic Ketogenic Diet in pediatric epilepsy treatment: A systematic review of clinical trials.

Sepehrar S, et al. · 2025

BACKGROUND/OBJECTIVE: Classic Ketogenic Diet (CKD) is a well-known diet therapy with high fat and low carbohydrates which is used to treat children with medication-resistant epilepsy (MRE). As CKD is …

Short-Term and Long-Term Effects of Bariatric Surgery on Diabetic Retinopathy: A Systematic Review.

Butkutė E, et al. · 2025

Background and Objectives: Diabetic retinopathy (DR) is a common diabetes complication and a leading cause of blindness. Although bariatric surgery (BS) is well studied for diabetes management, its ef…

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Cagigas Maria Lastra, Masedunskas Andrius, Lin Yao, Emery‐Corbin Samantha J., Yousef Jumana M., Dagley Laura F., Olechnowicz Sam, Bowden Rory et al. · 2025

Prediabetes, characterized by impaired fasting glucose and/or glucose tolerance, is associated with organ damage, increased mortality, and accelerated aging, even before diabetes onset. Severe short‐t…

Sleep features and the risk of type 2 diabetes mellitus: a systematic review and meta-analysis.

Liu H, et al. · 2025

OBJECTIVE: This study aimed to assess the associations between multidimensional sleep features and type 2 diabetes mellitus (T2DM). METHODS: We conducted a systematic search across the PubMed, Embase,…

Sucralose consumption modifies glucose homeostasis, gut microbiota, Curli protein, and related metabolites in healthy individuals: A randomized placebo-controlled, triple-blind trial.

Romo-Romo A, et al. · 2025

BACKGROUND & AIMS: Sucralose consumption has been associated with a reduction in insulin sensitivity, potentially through changes in gut microbiota, induction of low-grade inflammation and other patho…

Sustained metabolic improvements in a remotely delivered ketogenic nutrition programme for veterans with type 2 diabetes: A 3‐year observational study

Adams Rebecca N., Athinarayanan Shaminie J., Zoller Alison R., McKenzie Amy L., Ratner Robert E. · 2025

To evaluate the long‐term effectiveness and safety of a remote, medically supervised ketogenic nutrition therapy intervention for Veterans with type 2 diabetes (T2D). This retrospective observational …

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation.

Wu W, et al. · 2025

Consumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associat…

Tele-Cognitive Behavioral Therapy for the Treatment of Diabetes-Related Distress in Individuals With Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Xu X, et al. · 2025

BACKGROUND: Diabetes-related distress (DD) is highly prevalent in individuals with diabetes mellitus (DM) and impairs quality of life. Tele-cognitive behavioral therapy (Tele-CBT) shows potential for …

The Association Between Cost-Related Insulin Rationing and Health Care Utilization in U.S. Adults With Diabetes.

Borden CG, et al. · 2025

OBJECTIVE: To examine the association between insulin rationing and health care utilization. RESEARCH DESIGN AND METHODS: Cross-sectional study of all 2021 National Health Interview Survey respondents…

The Effects of Aspartame on Glucose, Insulin, and Appetite-Regulating Hormone Responses in Humans: Systematic Review and Meta-Analyses.

Boxall LR, et al. · 2025

Aspartame (L-α-aspartyl-L-phenylalanine methyl ester) has been implicated in increased risk of several chronic health conditions, yet underlying mechanisms remain unclear. The objective of this work w…

The Role of Insulin Sensitivity in Lean Mass Changes During Weight Loss With or Without Exercise

Bartholomew Ciera L., Martins Catia, Gower Barbara · 2025

This study aimed to investigate the association between baseline insulin sensitivity (S I ) and changes in total lean mass (LM) and appendicular LM (ALM) during a diet‐induced weight loss program with…

The bidirectional influence between type 2 diabetes mellitus and the state of depression and anxiety.

Xu H, et al. · 2025

Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease with several complications that has a negative impact on patients' physical and mental health. People's life pressures are increasing as …

The impact of technology on impaired awareness of hypoglycaemia in type 1 diabetes.

Berry SA, et al. · 2025

Iatrogenic hypoglycaemia remains a major barrier to optimal glycaemic control required to prevent long-term complications in people with type 1 diabetes (pwT1D). Hypoglycaemia is the consequence of th…

The interface of depression and diabetes: treatment considerations.

Fanelli G, et al. · 2025

This state-of-the-art review explores the relationship between depression and diabetes, highlighting the two-way influences that make treatment challenging and worsen the outcomes of both conditions. …

The lived reality of diabetic foot ulcers: a systematic review and meta-synthesis on patients' experiences and coping for a high-quality life.

Erjaee A, et al. · 2025

BACKGROUND: Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus, leading to infection, amputation, and reduced quality of life. Beyond their clinical impact, DFUs impose psychol…

The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis

Vahed Iman Elahi, Moshgelgosha Mahsa, Kor Abdolmajid, Minadi Mona, Ebrahimi Faezeh, Azhdarian Aylar, Arjmandi Mobina, Alamdar Aida et al. · 2025

Colorectal cancer ranks as the third most frequently diagnosed cancer globally. Adipokines, including adiponectin and leptin, are believed to play a vital role in the development and progression of tu…

The role of depression and diabetes distress in glycemic control: A meta-analysis.

Wojujutari Ajele K, et al. · 2025

AIMS: This study evaluated the associations between depression, diabetes distress, glycemic control (HbA1c), and self-care behaviours in individuals with diabetes. Findings on these relationships have…

Tirzepatide for Obesity Treatment and Diabetes Prevention.

Jastreboff AM, et al. · 2025

BACKGROUND: Obesity is a chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide su…

Trajectories of Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults.

Shen L, et al. · 2025

IMPORTANCE: Understanding the interplay between trajectories of sleep duration, sleep onset timing, and glycemic dynamics is crucial for improving preventive strategies against diabetes and related me…

Treatment regimens and glycaemic outcomes in more than 100 000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from paediatric diabetes registries.

Zimmermann AT, et al. · 2025

BACKGROUND: Advances in paediatric type 1 diabetes management and increased use of diabetes technology have led to improvements in glycaemia, reduced risk of severe hypoglycaemia, and improved quality…

Unraveling Type 1 Diabetes: Integrating Microbiome, Metabolomics, and Immunomodulation for Next-Generation Therapies

de Groen Pleun, Blok Lente C. H. M., Fuhri Snethlage Coco M., Hanssen Nordin M. J., Rampanelli Elena, Nieuwdorp Max · 2025

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T-cell-mediated destruction of pancreatic beta cells, resulting in insulin deficiency. Both genetic predisposition and environmen…

Validation of a Novel Patient-Reported Measure of The Burden of Digital Care in Diabetes.

Zahidy MA, et al. · 2025

BACKGROUND: Patients living with diabetes and chronic conditions may face significant burden managing their health. Many of these patients use digital medicine tools such as continuous glucose monitor…

Women's perspectives to improve prenatal care for gestational diabetes: A systematic review and meta-aggregation of qualitative studies.

Feng YJ, et al. · 2025

INTRODUCTION: In numerous qualitative primary studies, women have identified opportunities to improve prenatal gestational diabetes care. The objective of our systematic review and meta-aggregation wa…

Youth-Onset Type 2 Diabetes: What We've Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don't Know, and Why It Is Important.

Nadeau KJ, et al. · 2025

In this review, we describe the epidemiology, pathophysiology, pediatric-specific treatment response data, morbidity, and mortality of youth-onset type 2 diabetes. In recognition of the National Insti…

2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024.

· 2024

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study.

McKenzie AL, et al. · 2024

AIMS: This study assessed the five-year effects of a continuous care intervention (CCI) delivered via telemedicine, counseling people with type 2 diabetes (T2D) on a very low carbohydrate diet with nu…

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2024.

· 2024

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes: The EARLY Randomized Clinical Trial.

Guo L, et al. · 2024

IMPORTANCE: An intermittent fasting plan consisting of 2 nonconsecutive fasting days and 5 days of habitual intake per week and meal replacement diet (5:2 MR) could provide additional benefits to pati…

A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin

García-Muñoz Ana María, Victoria-Montesinos Desirée, Ballester Pura, Cerdá Begoña, Zafrilla Pilar · 2024

Oxidative stress is a key factor in the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, and liver disorders. Antioxidant therapies that target oxidative damage show s…

A Healthy, Low-Carbohydrate Diet During Pregnancy Is Associated With a Reduced Risk of Gestational Diabetes Mellitus.

Chen X, et al. · 2024

CONTEXT: Evidence on the associations of low-carbohydrate diet (LCD) during pregnancy with gestational diabetes mellitus (GDM) has been limited and inconsistent. OBJECTIVE: We aimed to prospectively e…

A Study on Yoga-Based Lifestyle Intervention versus Dietary Intervention Alone on Cardiometabolic Risk Factors among People with Prediabetes

Saboo Neha, Kacker Sudhanshu · 2024

Prediabetes is presented as a metabolic state that predisposes persons to a greater risk of diabetes progression in the future. Prediabetes is an intervening stage between normoglycemia and diabetes w…

A Systematic Review of Gut Microbiota Diversity: A Key Player in the Management and Prevention of Diabetes Mellitus

Koneru Hema Manvi, Sarwar Hooria, Bandi Venkata Varshitha, Sinha Mohit, Tarar Pakeeza, Bishara Rafik, Malasevskaia Iana · 2024

Diabetes mellitus represents a significant global health challenge, characterized by impaired insulin production and action, leading to elevated blood glucose levels. This systematic review investigat…

Adherence to a Mediterranean diet is associated with a lower risk of diabetic kidney disease among individuals with hyperglycemia: a prospective cohort study

Qu Changbo, Zhao Jinyu, Lai Jicai, Wu Xinxiang, Huang Peng, Zhu Ting, Li Yan, Liu Taoli et al. · 2024

Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular complications, neurological manifestations and poor wound healing. Adhering to a Mediterranean Diet (M…

Alpha-lipoic acid for diabetic peripheral neuropathy.

Baicus C, et al. · 2024

BACKGROUND: Diabetic peripheral neuropathy (DPN) is a frequent complication in people living with type 1 or type 2 diabetes. There is currently no effective treatment for DPN. Although alpha-lipoic ac…

Are e-Health Interventions Effective in Reducing Diabetes-Related Distress and Depression in Patients with Type 2 Diabetes? A Systematic Review with Meta-Analysis.

Fernández-Rodríguez R, et al. · 2024

Background: e-Health refers to any health care service delivered through the internet or related technologies, to improve quality of life. Despite the increasing use of e-health interventions to manag…

Artificial Light at Night and Type 2 Diabetes Mellitus.

Baek JH, et al. · 2024

The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor of natural circadian rhythms, potentially leading to a rise in…

Assessing Carbohydrate Counting Accuracy: Current Limitations and Future Directions

Amorim Débora, Miranda Francisco, Santos Andreia, Graça Luís, Rodrigues João, Rocha Mara, Pereira Maria Aurora, Sousa Clementina et al. · 2024

Diabetes mellitus is a prevalent chronic autoimmune disease with a high impact on global health, affecting millions of adults and resulting in significant morbidity and mortality. Achieving optimal bl…

Assessing the influence of insulin type (ultra-rapid vs rapid insulin) and exercise timing on postprandial exercise-induced hypoglycaemia risk in individuals with type 1 diabetes: a randomised controlled trial.

Molveau J, et al. · 2024

AIMS/HYPOTHESIS: The relationship between pre-meal insulin type, exercise timing and the risk of postprandial exercise-induced hypoglycaemia in people living with type 1 diabetes is unknown. We aimed …

Association Between Type 1 Diabetes Mellitus and Eating Disorders: A Systematic Review and Meta-Analysis.

Dean YE, et al. · 2024

BACKGROUND: Previous meta-analyses have shown mixed results regarding the association between eating disorders (EDs) and type 1 diabetes mellitus (T1DM). Our paper aimed to analyse different EDs and d…

Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study

Park Jiyun, Jung Jin-Hyung, Park Hyunju, Song Young Shin, Kim Soo-Kyung, Cho Yong-Wook, Han Kyungdo, Kim Kyung-Soo · 2024

We investigated the association between exercise habits before or after thyroidectomy and incident type 2 diabetes mellitus (T2DM) in patients with thyroid cancer. An observational cohort study of 69,…

Association between gut microbiota and diabetic microvascular complications: a two-sample Mendelian randomization study

Zhou Peipei, Hao Zhenning, Chen Yu, Zhang Ziqi, Xu Weilong, Yu Jiangyi · 2024

Gut microbiota (GM) homeostasis in the human body is closely associated with health, which can be used as a regulator for preventing the onset and progression of disease. Diabetic microvascular compli…

Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studies.

Wallerer S, et al. · 2024

BACKGROUND: Suboptimal diet quality is a key risk factor for premature death. Assuming relatively stable energy intake among individuals, changes in nutrient intakes occur by exchanging different nutr…

Associations between Disordered Eating Behaviors and HbA1c in Young People with Type 1 Diabetes: A Systematic Review and Meta-analysis.

Marks KP, et al. · 2024

BACKGROUND: In type 1 diabetes, disordered eating behaviors (DEB) can adversely impact HbA1c. Diabetes-adapted DEB questionnaires assess intentional insulin omission, whereas generic questionnaires do…

Associations of Adipokine Levels With Levels of Remnant Cholesterol: The Multi‐Ethnic Study of Atherosclerosis

Quispe Renato, Sweeney Ty, Martin Seth S., Jones Steven R., Allison Matthew A., Budoff Matthew J., Ndumele Chiadi E., Elshazly Mohamed B. et al. · 2024

The metabolic syndrome phenotype of individuals with obesity is characterized by elevated levels of triglyceride‐rich lipoproteins and remnant particles, which have been shown to be significantly athe…

Autoimmune diseases and adverse pregnancy outcomes: an umbrella review.

Singh M, et al. · 2024

BACKGROUND: There is a high prevalence of autoimmune conditions in women specially in the reproductive years; thus, the association with adverse pregnancy outcomes has been widely studied. However, fe…

Barriers and facilitators of self-management of diabetes amongst people experiencing socioeconomic deprivation: A systematic review and qualitative synthesis.

Woodward A, et al. · 2024

BACKGROUND: The number of people living with diabetes is rising worldwide and a higher prevalence of diabetes has been linked to those experiencing socioeconomic deprivation. Self-management strategie…

Bringing an end to diabetes stigma and discrimination: an international consensus statement on evidence and recommendations.

Speight J, et al. · 2024

People with diabetes often encounter stigma (ie, negative social judgments, stereotypes, prejudice), which can adversely affect emotional, mental, and physical health; self-care, access to optimal hea…

Cellular and Molecular Pathophysiology of Gestational Diabetes.

Torres-Torres J, et al. · 2024

Gestational diabetes (GD) is a metabolic disorder characterized by glucose intolerance during pregnancy, significantly impacting maternal and fetal health. Its global prevalence is approximately 14%, …

Cellular mechanisms of incretin hormone secretion.

Santos-Hernández M, et al. · 2024

Enteroendocrine cells located along the gastrointestinal epithelium sense different nutrients/luminal contents that trigger the secretion of a variety of gut hormones with different roles in glucose h…

Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review.

Georgaki MN, et al. · 2024

Diabetes is a global public health concern with increasing prevalence worldwide. Chromium (Cr), a trace element found in soil, water, and food, has been proposed to have a possible positive effect in …

Chronic Insufficient Sleep in Women Impairs Insulin Sensitivity Independent of Adiposity Changes: Results of a Randomized Trial.

Zuraikat FM, et al. · 2024

OBJECTIVE: Insufficient sleep is associated with type 2 diabetes, yet the causal impact of chronic insufficient sleep on glucose metabolism in women is unknown. We investigated whether prolonged mild …

Chrononutrition in type 2 diabetes mellitus and obesity: A narrative review.

Verde L, et al. · 2024

Chrononutrition is a nutritional regimen that follows our biological clock, marked by the changes in metabolism that occur during the day. This regimen includes the distribution of energy, the regular…

Circadian desynchrony and glucose metabolism.

Speksnijder EM, et al. · 2024

The circadian timing system controls glucose metabolism in a time-of-day dependent manner. In mammals, the circadian timing system consists of the main central clock in the bilateral suprachiasmatic n…

Combination of Blood Adiponectin and Leptin Levels Is a Predictor of Biochemical Recurrence in Prostate Cancer Invading the Surrounding Adipose Tissue

Suzuki Atsuto, Sato Shinya, Nakaigawa Noboru, Kishida Takeshi, Miyagi Yohei · 2024

Biochemical recurrence is a process that progresses to castration-resistant prostate cancer (CRPC) and prediction of biochemical recurrence is useful in determining early therapeutic intervention and …

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.

Yao H, et al. · 2024

OBJECTIVE: To evaluate the comparative efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycaemic control, body weight, and lipid profile in adults with type 2 diabetes. …

Comprehensive insights into berberine's hypoglycemic mechanisms: A focus on ileocecal microbiome in db/db mice

Chen Xuan, Mei Xi-yu, Ren Ze-ming, Chen Si-si, Tong Ye-ling, Zhang Cui-ping, Chen Jia, Dai Guan-hai · 2024

The efficacy of berberine in managing diabetes through modulation of gut microbiome has been established through fecal sample analyses. However, relying solely on fecal materials constrains our compre…

Consensus Paper: Latent Autoimmune Cerebellar Ataxia (LACA).

Manto M, et al. · 2024

Immune-mediated cerebellar ataxias (IMCAs) have diverse etiologies. Patients with IMCAs develop cerebellar symptoms, characterized mainly by gait ataxia, showing an acute or subacute clinical course. …

Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis.

Jancev M, et al. · 2024

AIMS/HYPOTHESIS: Continuous glucose monitoring (CGM) is increasingly used in the treatment of type 2 diabetes, but the effects on glycaemic control are unclear. The aim of this systematic review and m…

Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.

Levis B, et al. · 2024

IMPORTANCE: Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. OBJECTIVE: To evaluate the deg…

Diabetes Stigma and Clinical Outcomes: An International Review.

Eitel KB, et al. · 2024

Diabetes stigma is the social burden of living with diabetes. People with diabetes may experience or perceive an adverse social judgment, prejudice, or stereotype about living with diabetes at work, s…

Diabetes remission in newly diagnosed type 2 diabetes mellitus through short‐term continuous subcutaneous insulin infusion intensive therapy combined with low‐carbohydrate diet treatment

Huang Xuemei, Jiang Jiajin, Liu Li, Lin Yuanyuan, Zhang Feng, Ling Xiaoshan, Wei Haitao, Huang Guangjing et al. · 2024

To evaluate the therapeutic efficacy short‐term continuous subcutaneous insulin infusion (CSII) intensive therapy combined with a low‐carbohydrate diet (LCD) for diabetes remission in patients with ne…

Diabetic Ketoacidosis: Evaluation and Treatment.

Veauthier B, et al. · 2024

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 and type 2 diabetes resulting from an absolute or relative insulin deficiency. It can occur in patients of all ages and can be …

Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials.

Ran GL, et al. · 2024

BACKGROUND: Alpha-lipoic acid, epalrestat, and mecobalamin are widely used as monotherapies for diabetic peripheral neuropathy. However, whether a triple-combination therapy with these three drugs is …

EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

, et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the presence of one or mor…

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD): Executive Summary.

, et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the presence of one or mor…

ESPEN practical short micronutrient guideline.

Berger MM, et al. · 2024

BACKGROUND: Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. The importance of MNs in common pathologies is recognized by recent research, with def…

Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial.

Tricò D, et al. · 2024

AIMS/HYPOTHESIS: Early time-restricted carbohydrate consumption (eTRC) is a novel dietary strategy that involves restricting carbohydrate-rich food intake to the morning and early afternoon to align w…

Effect of 5:2 Regimens: Energy-Restricted Diet or Low-Volume High-Intensity Interval Training Combined With Resistance Exercise on Glycemic Control and Cardiometabolic Health in Adults With Overweight/Obesity and Type 2 Diabetes: A Three-Arm Randomized Controlled Trial

Li Mian, Li Jie, Xu Yu, Gao Jinli, Cao Qiuyu, Ding Yi, Xin Zhuojun, Lu Ming et al. · 2024

We aimed to examine the effects of a 5:2 diet (2 days per week of energy restriction by formula diet) or an exercise (2 days per week of high-intensity interval training and resistance training) inter…

Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis.

Garza MC, Pérez-Calahorra S, Rodrigo-Carbó C, Sánchez-Calavera MA, Jarauta E, Mateo-Gallego R, Gracia-Rubio I, Lamiquiz-Moneo I, et al. · 2024

BACKGROUND: The Mediterranean Diet (MedDiet) is the dietary pattern par excellence for managing and preventing metabolic diseases, such as Type 2 Diabetes (T2DM). The MedDiet incorporates spices and a…

Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with

da Silva Letícia B. G., Zajdenverg Lenita, Keating Elisa, Silvestre Manoela Pereira Smith, dos Santos Beatriz M. B., Saunders Cláudia · 2024

Objective : to evaluate the effect of prenatal care (PC) on perinatal outcomes of pregnant women with diabetes mellitus (DM). Methods : systematic review developed according to Preferred Reporting Ite…

Effect of automated insulin delivery systems on person-reported outcomes in people with diabetes: a systematic review and meta-analysis.

Roos T, et al. · 2024

BACKGROUND: Conclusive evidence on the benefits of automated insulin delivery (AID) systems on person-reported outcomes (PROs) is missing. METHODS: In this systematic review and meta-analysis, four da…

Effect of intermittent fasting 16:8 and 14:10 compared with control-group on weight reduction and metabolic outcomes in obesity with type 2 diabetes patients: A randomized controlled trial.

Sukkriang N, et al. · 2024

AIMS/INTRODUCTION: To compare the percent weight change and metabolic outcomes among diabetic participants with obesity on intermittent fasting (IF) 16:8, IF 14:10, or normal controlled diets. MATERIA…

Effect of low-and non-calorie sweeteners on the gut microbiota: A review of clinical trials and cross-sectional studies.

Gauthier E, et al. · 2024

Use of non-nutritive sweeteners (NNSs) has increased worldwide in recent decades. However, evidence from preclinical studies shows that sweetener consumption may induce glucose intolerance through cha…

Effect of patient-centered self-management intervention on glycemic control, self-efficacy, and self-care behaviors in South Asian adults with type 2 diabetes mellitus: A multicenter randomized controlled trial.

Asmat K, et al. · 2024

BACKGROUND: This study aimed to test the efficacy of patient-centered self-management intervention (PACE-SMI) to improve HbA1c, self-efficacy, and self-care behaviors in adults with type 2 diabetes me…

Effect of self-help interventions on psychological, glycemic, and behavioral outcomes in patients with diabetes: A meta-analysis of randomized controlled trials.

Wicaksana AL, et al. · 2024

BACKGROUND: Self-help interventions are beneficial for patients with diabetes; however, related studies have reported conflicting results. To date, no review has examined the effect of self-help inter…

Effect of stevia on blood glucose and HbA1C: A meta-analysis.

Zare M, et al. · 2024

BACKGROUND: The study investigates substituting non-nutritive sweeteners (NNS) for sugar to address health concerns related to excess sugar intake. It specifically examines how stevia affects insulin …

Effect of steviol glycosides as natural sweeteners on glucose metabolism in adult participants.

Bai X, et al. · 2024

Steviol glycosides (SGs) are recognized as safe natural sweeteners; however, evidence from randomized controlled trials (RCTs) showed an inconclusive effect of SGs on glucose metabolism in adult parti…

Effectiveness of Continuous Glucose Monitoring on Metrics of Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Uhl S, et al. · 2024

PURPOSE: To provide a systematic review and meta-analysis synthesizing the findings of randomized controlled trials (RCTs) of continuous glucose monitors (CGMs) in the management of adults with type 2…

Effectiveness of Prebiotics and Mediterranean and Plant-Based Diet on Gut Microbiota and Glycemic Control in Patients with Prediabetes or Type 2 Diabetes: A Systematic Review and Meta-Analysis

Dimba Nosipho Rosebud, Mzimela Nhlakanipho, Sosibo Aubrey Mbulelo, Khathi Andile · 2024

Background: A high-calorie diet results in the development of prediabetes (PD) or type 2 diabetes mellitus (T2DM). This diet has been reported to cause changes in microbial composition, concentration …

Effectiveness of acceptance and commitment therapy in people with type 2 diabetes mellitus: A systematic review and meta-analysis.

Wang M, et al. · 2024

BACKGROUND: Acceptance and commitment therapy (ACT) is a psychotherapy technique, which promotes psychological flexibility and enables patients to change behaviors based on value-directed goals. Howev…

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Zare Dehnavi A, et al. · 2024

AIMS: Studies suggested a higher prevalence of Attention-deficit/hyperactivity disorder (ADHD) in individuals with Type 1 Diabetes Mellitus (T1D). However, it is unclear how ADHD impacts glycemia and …

Effects of Dietary Approaches and Exercise Interventions on Gestational Diabetes Mellitus: A Systematic Review and Bayesian Network Meta-analysis.

Zhang L, et al. · 2024

Although lifestyle interventions are recommended as the frontline therapeutic strategy for women with gestational diabetes mellitus (GDM), the optimal dietary regimen or form of exercise has yet to be…

Effects of Integrated Care Approaches to Address Co-occurring Depression and Diabetes: A Systematic Review and Meta-analysis.

Cooper ZW, et al. · 2024

BACKGROUND: Depressive symptoms frequently co-occur with diabetes and, when unaddressed, can function to worsen diabetes control and increase the risk of diabetes-related morbidity. Integrated care (I…

Effects of a 12 Week Ketogenic Diet Intervention on Obese and Overweight Females with Glucose and Lipid Metabolism Disturbance

Klonek Grzegorz, Zydek Grzegorz, Roczniok Robert, Panek Mariusz, Zając Adam, Michalczyk Małgorzata Magdalena · 2024

Background/Objectives: We evaluated the effects of a 12-week hypocaloric ketogenic diet (KD) on glucose and lipid metabolism, as well as body mass, in overweight, obese, and healthy-weight females. On…

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance

Zhao Yang, Zhou Mengmeng, Shang Yongfang, Dou Mei, Gao Shan, Yang Hai, Zhang Fanghua · 2024

To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR). 120 indivi…

Effects of combined aerobic and resistance training on glycemic control, blood pressure, inflammation, cardiorespiratory fitness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis.

Al-Mhanna SB, et al. · 2024

BACKGROUND: Structured aerobic or resistance training alone seems to be a beneficial tool for improving glucose homeostasis, chronic systemic inflammation, resting cardiovascular function, and mental …

Effects of newer-generation anti-diabetics on diabetic retinopathy: a critical review.

Ntentakis DP, et al. · 2024

Diabetic retinopathy (DR) is the leading etiology of blindness in the working population of the USA. Its long-term management relies on effective glycemic control. Seven anti-diabetic classes have bee…

Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis.

· 2024

BACKGROUND: Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this e…

Efficacy of vitamin D supplementation on glycaemic control in type 2 diabetes: An updated systematic review and meta-analysis of randomized controlled trials.

Chen W, et al. · 2024

AIM: To assess the effects of vitamin D interventions on glycaemic control in subjects with type 2 diabetes (T2D). METHODS: We searched PubMed, EMBASE, Web of Science and the Cochrane Library for rele…

Emerging role of gut microbiota in autoimmune diseases

Wang Xinyi, Yuan Wei, Yang Chunjuan, Wang Zhangxue, Zhang Jin, Xu Donghua, Sun Xicai, Sun Wenchang · 2024

Accumulating studies have indicated that the gut microbiota plays a pivotal role in the onset of autoimmune diseases by engaging in complex interactions with the host. This review aims to provide a co…

Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men.

Gao Y, et al. · 2024

The efficacy of interrupting prolonged sitting may be influenced by muscle activity patterns. This study examined the effects of interrupting prolonged sitting time with different muscle activity patt…

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Mitchell Alexandra K., Bliss Rebecca R., Church Frank C. · 2024

Parkinson’s disease (PD) is a prevalent neurodegenerative disease in which treatment often includes an exercise regimen. Exercise is neuroprotective in animal models of PD, and, more recently, human c…

Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis

SHAO XinYi, PAN Xingyu, CHEN Tingqiao, CHEN Ziyan, LI Yuhao, ZHONG Judan, WANG Ruiyao, YU Jun et al. · 2024

Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipo…

Factors associated with psychological insulin resistance among patients with type 2 diabetes in China.

Zhang S, et al. · 2024

OBJECTIVE: The aim of this study was to understand the psychological insulin resistance status among Chinese patients with type 2 diabetes and investigate its associated factors in these patients. MET…

Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial.

van Eijnatten EJM, et al. · 2024

Background: In vitro studies suggest that casein coagulation of milk is influenced by its mineral composition, and may therefore affect the dynamics of protein digestion, gastric emptying and appearan…

Glucagon-like peptide agonists for weight management in antipsychotic-induced weight gain: A systematic review and meta-analysis.

Bak M, et al. · 2024

INTRODUCTION: Managing body weight in patients with antipsychotic-induced weight gain (AIWG) is challenging. Besides lifestyle interventions, pharmacological interventions may contribute to weight los…

Glucocorticoid-Induced Hyperglycemia: A Neglected Problem.

Cho JH, et al. · 2024

Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-…

Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update).

Bus SA, et al. · 2024

AIMS: This is the 2023 International Working Group on the Diabetic Foot guideline on the prevention of foot ulcers in persons with diabetes, which updates the 2019 guideline. This guideline is targete…

High prevalence of depression in parents of children with Type 1 diabetes in a meta-analysis of data from five continents.

Ryan H, et al. · 2024

AIM: This meta-analysis identified the prevalence of depression in parents of children with Type 1 diabetes. METHODS: MEDLINE, PsycINFO and CINAHL databases were searched for papers published in Engli…

Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease

Lengton Robin, Dekker Friedo W., van Rossum Elisabeth F. C., de Fijter Johan W., Rosendaal Frits R., van Dijk Ko Willems, Rabelink Ton J., Le Cessie Saskia et al. · 2024

Obesity may promote kidney damage through hemodynamic and hormonal effects. We investigated the association between body mass index (BMI), total body fat (TBF) and chronic kidney disease (CKD) and whe…

ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes.

Haller MJ, et al. · 2024

The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adole…

ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.

Shah AS, et al. · 2024

Youth-onset type 2 diabetes (T2D) results from genetic, environmental, and metabolic causes that differ among individuals and populations. This chapter builds on the 2022 ISPAD guidelines and summariz…

Impact of diverse aerobic exercise plans on glycemic control, lipid levels, and functional activity in stroke patients with type 2 diabetes mellitus.

Chen K, et al. · 2024

AIMS: This study aimed to assess the effects of Low-to-Moderate Intensity Continuous Training (LMICT), Moderate-Intensity Interval Training (MIIT), and Reduced-Exertion High-Intensity Training (REHIT)…

Influencing factors of glycemic control in singleton pregnancies complicated by gestational diabetes mellitus in western China: A retrospective study

Zhang Jiani, Mao Chihui, Cao Qi, Huang Guiqiong, Wang Xiaodong · 2024

To investigate the factors influencing glycemic control in gestational diabetes mellitus (GDM) patients and their impacts on pregnancy outcomes, providing insights for GDM management. Pregnant women d…

Ingestion of the Non-Nutritive Sweetener Erythritol, but Not Glucose, Enhances Platelet Reactivity and Thrombosis Potential in Healthy Volunteers-Brief Report.

Witkowski M, et al. · 2024

BACKGROUND: Although artificial and non-nutritive sweeteners are widely used and generally recognized as safe by the US and European Union regulatory agencies, there have been no clinical trials to as…

Intermittent fasting as a treatment for obesity in young people: a scoping review

Bakhsh Jomanah, Salvy Sarah-Jeanne, Vidmar Alaina P. · 2024

Intermittent fasting focuses on the timing of eating rather than diet quality or energy intake, with evidence supporting its effects on weight loss and improvements in cardiometabolic outcomes in adul…

Ketogenic Diet and Its Potential Role in Preventing Type 2 Diabetes Mellitus and Its Complications: A Narrative Review of Randomized Controlled Trials

Alluwyam Ali H, Estrella Edric D · 2024

Diabetes mellitus is a global health crisis affecting millions. Nutrition plays a vital role in its management and prevention. While carbohydrate reduction is beneficial for glycemic control, various …

Ketogenic Diet: A Review of Composition Diversity, Mechanism of Action and Clinical Application.

Malinowska D, et al. · 2024

The ketogenic diet (KD) is a special high-fat, very low-carbohydrate diet with the amount of protein adjusted to one's requirements. By lowering the supply of carbohydrates, this diet induces a consid…

Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT.

Hengist A, et al. · 2024

Restricted sugar and ketogenic diets can alter energy balance/metabolism, but decreased energy intake may be compensated by reduced expenditure. In healthy adults, randomization to restricting free su…

Long-term metabolic effects of non-nutritive sweeteners.

Rathaus M, et al. · 2024

OBJECTIVE: Excessive consumption of added sugars has been linked to the rise in obesity and associated metabolic abnormalities. Non-nutritive sweeteners (NNSs) offer a potential solution to reduce sug…

Low-Glycemic Load Diets and Thyroid Function: A Narrative Review and Future Perspectives

Partsalaki Ioanna, Markantes Georgios K., Michalaki Marina A. · 2024

Nutrition and calorie intake are associated with subtle changes of thyroid function tests in subjects with an intact Hypothalamic-Pituitary-Thyroid axis. Iodine deficiency and extreme fluctuations in …

Meal timing and its role in obesity and associated diseases.

Peters B, et al. · 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between the endogenous circadian clock and metabolic homeostasis. Mistimed food inta…

Measuring treatment burden in people with Type 2 Diabetes Mellitus (T2DM): a mixed-methods systematic review.

Lin K, et al. · 2024

BACKGROUND: Measuring treatment burden is important for the effective management of Type 2 Diabetes Mellitus (T2DM) care. The purpose of this systematic review was to identify the most robust approach…

Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries.

Li C, et al. · 2024

BACKGROUND: Meat consumption could increase the risk of type 2 diabetes. However, evidence is largely based on studies of European and North American populations, with heterogeneous analysis strategie…

Medication-Induced Hyperglycemia and Diabetes Mellitus: A Review of Current Literature and Practical Management Strategies.

Jain AB, et al. · 2024

With the increasing global incidence of diabetes mellitus, physicians may encounter more patients with acute and chronic complications of medication-induced hyperglycemia and diabetes. Moreover, medic…

Metformin Use and Vitamin B12 Deficiency in People with Type 2 Diabetes. What Are the Risk Factors? A Mini-systematic Review.

Atkinson M, et al. · 2024

Background and Aim: Metformin is recommended as the first-line agent for the management of type 2 diabetes following lifestyle and dietary changes. The long-term use of metformin has been associated w…

Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Melin J, Forslund M, Alesi S, Piltonen T, Romualdi D, Spritzer PM, Tay CT, Pena A, et al. · 2024

CONTEXT: Polycystic ovary syndrome (PCOS) affects more than 1 in 10 women. OBJECTIVE: As part of the 2023 International PCOS Guidelines update, comparisons between combined oral contraceptive pills (C…

Multidimensional sleep health and diabetic retinopathy: Systematic review and meta-analysis.

Simonson M, et al. · 2024

Diabetic retinopathy (DR) is one of the most prevalent microvascular diabetic complications. Poor sleep health and obstructive sleep apnea (OSA) are risk factors for diabetes and poor glycemic control…

Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Clinical Guideline From the American College of Physicians.

Qaseem A, et al. · 2024

DESCRIPTION: The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments of type 2 diabetes. This clinical guideline is based…

Nutraceuticals and Supplements in Management of Prediabetes and Diabetes

Derosa Giuseppe, D’Angelo Angela, Angelini Fabrizio, Belli Luca, Cicero Arrigo F. G., Da Ros Roberto, De Pergola Giovanni, Gaudio Giovanni V. et al. · 2024

Dysglycemia is a condition preceding diabetes mellitus. The two situations inherent in this condition are called impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). If one of these si…

Nutritional support in hospitalised patients with diabetes and risk for malnutrition: a secondary analysis of an investigator-initiated, Swiss, randomised controlled multicentre trial

Keller Bettina, Wunderle Carla, Tribolet Pascal, Stanga Zeno, Kaegi-Braun Nina, Mueller Beat, Schuetz Philipp · 2024

The main objective of this study was to investigate the effects of nutritional support on mortality in hospitalised patients with diabetes and nutritional risk participating in the Effect of early nut…

Objective Burden and Emotional Distress of Parents of Children with Type 1 Diabetes.

Bazus L, et al. · 2024

INTRODUCTION: The management of childhood type 1 diabetes requires the active participation of parents. The aim of the present study was to describe the main characteristics of parents of children wit…

Out-of-pocket expenses and rationing of insulin and diabetes supplies: findings from the 2022 T1International cross-sectional web-based survey.

Souris KJ, et al. · 2024

INTRODUCTION: Continue investigating Out-of-Pocket Expenses (OoPEs) and rationing of insulin and diabetes supplies, including impacts of the COVID-19 pandemic, for people with type 1 diabetes (T1D). M…

Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy

Tang Shanshan, An Xuedong, Sun Wenjie, Zhang Yuehong, Yang Cunqing, Kang Xiaomin, Sun Yuting, Jiang Linlin et al. · 2024

Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respecti…

Patient-reported outcomes in studies of diabetes technology: What matters.

Liarakos AL, et al. · 2024

In recent years, diabetes technologies have revolutionized the care of people with type 1 diabetes (T1D). Emerging evidence suggests that people with type 2 diabetes (T2D) can experience similar benef…

Pea Albumin Extracted from Pea ( Pisum sativum L.) Seeds Ameliorates High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease by Regulating Lipogenesis and Lipolysis Pathways

Zhang Shucheng, Cui Zhengwu, Zhang Hao, Wang Pengjie, Wang Fuqing, Zhang Jian · 2024

Non-alcoholic fatty liver disease (NAFLD) is now recognized as the most prevalent liver disease globally. Pea albumin (PA) has demonstrated positive impacts on reducing obesity and improving glucose m…

Polyunsaturated fatty acids and diabetic microvascular complications: a Mendelian randomization study

Liu Bingyang, Liu Ruiyan, Gu Yi, Shen Xiaoying, Zhou Jianqing, Luo Chun · 2024

Observational studies and clinical trials have implicated polyunsaturated fatty acids (PUFAs) in potentially safeguarding against diabetic microvascular complication. Nonetheless, the causal nature of…

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis.

Jones A, et al. · 2024

INTRODUCTION: The prevalence of mild and major neurocognitive disorders (NCDs), also referred to as mild cognitive impairment and dementia, is rising globally. The prevention of NCDs is a major global…

Practice effects of personalized interventions with interdisciplinary teamwork in type 2 diabetes remission: a retrospective study

Tian Xiaona, Tang Yujin, Hu Rongrui, Ye Jianhong, Chen Haixin, Wu Junjie · 2024

A retrospective analysis of the clinical outcomes of personalized interventions for type 2 diabetes mellitus (T2DM) in an interdisciplinary team. Under the guidance of an interdisciplinary team, 40 pa…

Prevalence and determinants of perinatal mental disorders in women with gestational diabetes in New Zealand: Findings from a national longitudinal study.

Ohene-Agyei P, et al. · 2024

INTRODUCTION: Concurrent diagnosis of gestational diabetes mellitus and mental disorders is associated with adverse outcomes for mother and child, but there is limited information about prevalence or …

Promoting Resilience in Stress Management for Adolescents With Type 1 Diabetes: A Randomized Clinical Trial.

Yi-Frazier JP, et al. · 2024

IMPORTANCE: Type 1 diabetes (T1D) requires demanding self-management health behaviors, and adolescents with T1D are at risk for poor psychosocial and medical outcomes. Developing resilience skills may…

Psychological insulin resistance and its impact on self-management in type II diabetes mellitus patients treated with insulin therapy.

Fu CH, et al. · 2024

AIMS: Psychological insulin resistance is a common barrier to initiation and persistence with insulin therapy that affects approximately 42.7% of people living with type II diabetes mellitus, which ma…

Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.

Huerta-Chagoya A, et al. · 2024

Type 2 diabetes (T2D) genome-wide association studies (GWASs) often overlook rare variants as a result of previous imputation panels' limitations and scarce whole-genome sequencing (WGS) data. We used…

Reevaluating Adiponectin’s impact on obesity hypertension: a Chinese case-control study

Wu Ou, Lu Xi, Leng Jianhang, Zhang Xingyu, Liu Wei, Yang Fenfang, Zhang Hu, Li Jiajia et al. · 2024

Obesity and hypertension are major risk factors for cardiovascular diseases that affect millions of people worldwide. Both conditions are associated with chronic low-grade inflammation, which is media…

Reliability and validity of a parent-reported screening tool for disordered eating in children and young people with type 1 diabetes.

Harrington MP, et al. · 2024

BACKGROUND: There is a high prevalence and complex overlap between type 1 diabetes (T1D) and disordered eating. However, screening for disordered eating in children and young people (CYP) with T1D is …

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota.

Li H, et al. · 2024

Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003…

Risk factors for diabetic foot ulcers: A systematic review and meta-analysis.

Tang WH, et al. · 2024

OBJECTIVE: To systematically evaluate the risk factors for developing diabetic foot ulcers (DFU). METHODS: The Cochrane Library, PubMed, Web of Science, SinoMed, CNKI, VIP, and Wanfang Data were searc…

Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis.

Dilixiati D, et al. · 2024

BACKGROUND: Previous studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk factors associate…

Risk factors for nephrolithiasis formation: an umbrella review.

Ma Y, et al. · 2024

OBJECTIVE: Nephrolithiasis is prevalent and burdensome worldwide. At present, evidence on the risk factors for nephrolithiasis is unconsolidated and the associations remain uncertain. The authors syst…

Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System.

Ozcan M, et al. · 2024

Population aging and the associated increase in cardiovascular disease rates pose serious threats to global public health. Different forms of fasting have become an increasingly attractive strategy to…

Safety of Empagliflozin: An Individual Participant-Level Data Meta-Analysis from Four Large Trials.

Wanner C, et al. · 2024

INTRODUCTION: Empagliflozin is a sodium-glucose co-transporter-2 inhibitor used to treat type 2 diabetes (T2D) to improve glycemic control, reduce risk of cardiovascular death in patients with T2D, an…

Schizophrenia and type 2 diabetes risk: a systematic review and meta-analysis.

Dong K, et al. · 2024

OBJECTIVES: The metabolic syndrome in patients with schizophrenia has consistently been a challenge for clinicians. Previous studies indicate that individuals with schizophrenia are highly prone to de…

Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus.

Liang YY, et al. · 2024

RATIONALE & OBJECTIVE: Social disconnection has been associated with poor cardiometabolic health. This study sought to investigate the associations of social isolation and loneliness with diabetic mic…

Statins and new-onset diabetes in primary prevention setting: an updated meta-analysis stratified by baseline diabetes risk.

Masson W, et al. · 2024

AIMS: The use of statins has been associated with an increased risk of new-onset diabetes. The characteristics of the population could influence this association. The objective of this study was to de…

Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes.

Mei Z, et al. · 2024

The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity of this disease and variation in study design. Even in cases in which individua…

Studies on the Effect of Piperine on Hepatocyte Nuclear Factor 1 Alpha (HNF-1α) and Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) Levels in High-Fat-Diet and Sucrose-Induced Type 2 Diabetes Mellitus Rats

Zuvairiya Ummu, Jayaraman Selvaraj, Sankaran Kavitha, Veeraraghavan Vishnu Priya, R Gayathri · 2024

Background: Piperine, a naturally occurring compound in black pepper ( Piper nigrum ), is known for its potential health benefits, including its reported enhancement of insulin sensitivity. However, t…

Suicidal Ideation, Suicide Attempts, and Suicide Deaths in Adolescents and Young Adults With Type 1 Diabetes: A Systematic Review and Meta-analysis.

Renaud-Charest O, et al. · 2024

BACKGROUND: Evidence is lacking on the risk of suicide-related behaviors (suicidal ideation, suicide attempt, suicide death) in youth with type 1 diabetes (T1D). PURPOSE: We aimed to 1) determine the …

Suicide death, suicidal ideation and suicide attempt in patients with diabetes: A systematic review and meta-analysis.

Fan ZH, et al. · 2024

AIMS: Diabetes has been indicated to be a risk factor for suicide. We aim to estimate the prevalence of suicide in patients with diabetes. DESIGN: A meta-analysis using PRISMA methodology was adopted …

Suppression of the postprandial hyperglycemia in patients with type 2 diabetes by a raw medicinal herb powder is weakened when consumed in ordinary hard gelatin capsules: A randomized crossover clinical trial.

Moreira FD, Reis CEG, Gallassi AD, Moreira DC, Welker AF · 2024

INTRODUCTION: Contradictory claims about the efficacy of several medicinal plants to promote glycemic control in patients with type 2 diabetes mellitus (T2DM) have been explained by divergences in the…

Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish model

Roohi Tamsheel Fatima, Krishna K. L., Shakeel Faiyaz · 2024

Diabetic nephropathy (DN) can be prevented with early therapeutic intervention in diabetic patients. Recent investigations suggest that β-amyrin, a pentacyclic triterpenoid, could offer significant be…

Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.

Bahri Khomami M, et al. · 2024

Screening for polycystic ovary syndrome (PCOS) in antenatal care is inadequate, largely owing to the lack of clarity around whether PCOS is an independent risk factor for pregnancy complications. This…

The Effect of Adding Protein to a Carbohydrate Meal on Postprandial Glucose and Insulin Responses: A Systematic Review and Meta-Analysis of Acute Controlled Feeding Trials.

Wolever TM, et al. · 2024

BACKGROUND: Protein influences acute postprandial glucose and insulin responses, but the effects of dose, protein type, and health status are unknown. OBJECTIVES: We aimed to determine the acute effec…

The Effect of Microbiome-Modulating Agents (MMAs) on Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang Ying, Huang Aiying, Li Jun, Munthali William, Cao Saiying, Putri Ulfah Mahardika Pramono, Yang Lina · 2024

Gut microbiome-modulating agents (MMAs), including probiotics, prebiotics, postbiotics, and synbiotics, are shown to ameliorate type 1 diabetes (T1D) by restoring the microbiome from dysbiosis. The ob…

The Global Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among Patients With Type 2 Diabetes.

Younossi ZM, et al. · 2024

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction associated steatotic liver disease (MASLD), is closely associated with type 2 diabetes (T2D). Our aim wa…

The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Wan Y, et al. · 2024

Background: The prevalence of type 2 diabetes mellitus (T2DM) presents a challenge for health organizations because of its high likelihood of morbidity and mortality. There is an increasing body of ev…

The Role of the Glycemic Index and Glycemic Load in the Dietary Approach of Gestational Diabetes Mellitus

Mavroeidi Ioanna, Manta Aspasia, Asimakopoulou Athina, Syrigos Alexandros, Paschou Stavroula A., Vlachaki Efthimia, Nastos Constantinos, Kalantaridou Sophia et al. · 2024

Gestational diabetes mellitus (GDM) is a common metabolic disorder that often develops during pregnancy, characterized by glucose intolerance and insulin resistance (IR). To ensure the well-being of b…

The case for screening for diabetes distress, depression, and anxiety.

Michot AP, et al. · 2024

Our goal was to determine the prevalence of anxiety and depression in a sample of U.S. military veterans with type 2 diabetes and elevated diabetes distress (DD). Cross-sectional analyses were conduct…

The effectiveness of diabetes self-management education intervention on glycaemic control and cardiometabolic risk in adults with type 2 diabetes in low- and middle-income countries: A systematic review and meta-analysis.

Chowdhury HA, et al. · 2024

Diabetes mellitus (DM) poses a significant challenge to public health. Effective diabetes self-management education (DSME) interventions may play a pivotal role in the care of people with type 2 diabe…

The effectiveness of psychological interventions on diabetes distress and glycemic level in adults with type 2 diabetes: a systematic review and meta-analysis.

Zu W, et al. · 2024

AIMS: The treatment of diabetes distress plays an important role in diabetes care; however, no meta-analysis has been performed to synthesize the short- and long-term effects of psychological interven…

The emerging role of glucagon-like peptide 1 in binge eating.

Balantekin KN, et al. · 2024

Binge eating is a central component of two clinical eating disorders: binge eating disorder and bulimia nervosa. However, the large treatment gap highlights the need to identify other strategies to de…

The impacts and mechanisms of dietary proteins on glucose homeostasis and food intake: a pivotal role of gut hormones.

Zhang M, et al. · 2024

Glucose and energy metabolism disorders are the main reasons induced type 2 diabetes (T2D) and obesity. Besides providing energy, dietary nutrients could regulate glucose homeostasis and food intake v…

The role of high mobility group box-1 on the development of diabetes complications: A plausible pharmacological target

Ngcobo Nokwanda N, Sibiya Ntethelelo H · 2024

Diabetes mellitus has emerged as a pressing global concern, with a notable increase in recent years. Despite advancements in treatment, existing medications struggle to halt the progression of diabete…

The role of low glycemic index and load diets in medical nutrition therapy for type 2 diabetes: an update

Gerontiti Eleni, Shalit Almog, Stefanaki Katerina, Kazakou Paraskevi, Karagiannakis Dimitrios S., Peppa Melpomeni, Psaltopoulou Theodora, Paschou Stavroula A. · 2024

The increasing prevalence of type 2 diabetes mellitus (T2DM) and its microvascular and macrovascular complications necessitate an optimal approach to prevention and management. Medical nutrition thera…

Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.

Manoogian ENC, et al. · 2024

BACKGROUND: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. OBJECTIVE: To determine…

Two distinct psychological concepts: Diabetes depression and diabetes burnout profiles.

Noorian K, et al. · 2024

BACKGROUND: Diabetes burnout represents a unique experience that shares some similarities with other psychological concepts. Differentiating diabetes burnout from depression symptoms is a challenging …

Type 2 Diabetes and Fracture Risk in Older Women.

Zoulakis M, et al. · 2024

IMPORTANCE: The reasons for the increased fracture risk in type 2 diabetes (T2D) are not fully understood. OBJECTIVE: To determine if poorer skeletal characteristics or worse physical function explain…

Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses.

Lane MM, et al. · 2024

OBJECTIVE: To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classification system, and adverse health outcomes. DE…

Ultra-processed foods and human health: An umbrella review and updated meta-analyses of observational evidence.

Dai S, et al. · 2024

BACKGROUND & AIMS: Ultra-processed food (UPF) intake has increased sharply over the last few decades and has been consistently asserted to be implicated in the development of non-communicable diseases…

Understanding Experiences of Diabetes Distress: A Systematic Review and Thematic Synthesis.

Morales-Brown LA, et al. · 2024

Background: Diabetes distress is a common emotional issue for those living with diabetes, which has the potential to negatively impact well-being, management behaviors, and HbA1c levels. These implica…

Understanding the cause of type 2 diabetes.

Taylor R · 2024

Type 2 diabetes has long been thought to have heterogenous causes, even though epidemiological studies uniformly show a tight relationship with overnutrition. The twin cycle hypothesis postulated that…

Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus

Luppi Stefania, Aldegheri Luana, Azzalini Eros, Pacetti Emanuele, Barucca Sebastiani Giulia, Fabiani Carolina, Robino Antonietta, Comar Manola · 2024

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and the need for lifelong insulin therapy. Although gen…

Vaccinium spp. Berries in the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Update of Preclinical and Clinical Research

Książek Ewelina, Goluch Zuzanna, Bochniak Marta · 2024

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder marked by the buildup of triacylglycerols (TGs) in the liver. It includes a range of conditions, from simple steatosis to m…

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.

Demay MB, et al. · 2024

BACKGROUND: Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety of common disorders, including musculoskeletal, metabolic, cardiovascu…

Vitamins C, E, and β-Carotene and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Lampousi AM, et al. · 2024

A systematic review and meta-analysis was conducted to assess the relationship between the common dietary antioxidants vitamin C, vitamin E, and β-carotene and type 2 diabetes (T2D) and related traits…

Xylitol is prothrombotic and associated with cardiovascular risk.

Witkowski M, et al. · 2024

BACKGROUND AND AIMS: The pathways and metabolites that contribute to residual cardiovascular disease risks are unclear. Low-calorie sweeteners are widely used sugar substitutes in processed foods with…

Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.

Nazari M, et al. · 2024

Zinc supplementation has therapeutic effects on cardiovascular disease (CVD) risk factors, including dyslipidemia, hyperglycemia, and inflammation as the main contributors to CVD pathogenesis. Since C…

"It feels like medically promoted disordered eating": The psychosocial impact of gestational diabetes mellitus in the perinatal period.

Benton M, et al. · 2023

BACKGROUND: The global prevalence of gestational diabetes mellitus (GDM) is increasing, and it can significantly impact women's psychosocial outcomes in the perinatal period. The aim of this study was…

2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023.

ElSayed NA, et al. · 2023

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general…

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.

Virani SS, et al. · 2023

AIM: The "2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease" provides an update to and consolidates new evidence since the "2012 ACCF/AHA/ACP/AATS/…

A Nutritional Approach to Optimizing Pump Therapy in Type 1 Diabetes Mellitus

Gitsi Evdoxia, Livadas Sarantis, Angelopoulos Nicholas, Paparodis Rodis D., Raftopoulou Marina, Argyrakopoulou Georgia · 2023

Achieving optimal glucose control in individuals with type 1 diabetes (T1DM) continues to pose a significant challenge. While continuous insulin infusion systems have shown promise as an alternative t…

A Randomized Controlled Pilot Study of the Food Order Behavioral Intervention in Prediabetes.

Shukla AP, et al. · 2023

(1) Background: Prior research in individuals with overweight/obesity and prediabetes or type 2 diabetes has shown that the ingestion of protein-rich food and non-starchy vegetables before concentrate…

A comparative study of the gut microbiome in Indian children with type 1 diabetes and healthy controls

Tamahane Vaishali, Bhanushali Shivang, Shah Nikhil, Gupta Abhishek, Khadilkar Vaman, Gondhalekar Ketan, Khadilkar Anuradha, Shouche Yogesh · 2023

Type 1 diabetes mellitus (T1DM) occurs in genetically susceptible individuals due to certain environmental triggers causing destruction of insulin secreting beta cells. One of the environmental trigge…

A comparative study to assess the use of chromium in type 2 diabetes mellitus

Alkhalidi Fatima · 2023

Diabetes mellitus is a prevalent endocrine disorder characterized by elevated blood glucose levels, often resulting in complications affecting multiple organs, such as retinopathy, nephropathy, and ne…

A comparison of the effects of resistant starch types on glycemic response in individuals with type 2 diabetes or prediabetes: A systematic review and meta-analysis.

Pugh JE, et al. · 2023

BACKGROUND: Type 2 diabetes (T2D) diagnoses are predicted to reach 643 million by 2030, increasing incidences of cardiovascular disease and other comorbidities. Rapidly digestible starch elevates post…

A systematic review of barriers and enablers that health professionals experience to the delivery of type 2 diabetes care for adults with severe mental illness.

Dorey T, et al. · 2023

BACKGROUND: People with severe mental illness have a heightened risk for type 2 diabetes. They also experience poorer outcomes, including more diabetes complications, more emergency admissions, lower …

Adherence to a Healthy Lifestyle in Association With Microvascular Complications Among Adults With Type 2 Diabetes

Liu Gang, Li Yanping, Pan An, Hu Yang, Chen Siyu, Qian Frank, Rimm Eric B., Manson JoAnn E. et al. · 2023

This cohort study evaluates the association between adherence to a healthy lifestyle and microvascular complications among adults with type 2 diabetes. Is adherence to a healthy lifestyle before and a…

Adiponectin–leptin ratio for the early detection of lean non-alcoholic fatty liver disease independent of insulin resistance

Lu Chia-Wen, Yang Kuen-Cheh, Chi Yu-Chiao, Wu Tsan-Yu, Chiang Chien-Hsieh, Chang Hao-Hsiang, Huang Kuo-Chin, Yang Wei-Shiung · 2023

Lean Non-alcoholic Fatty Liver Disease (NAFLD) shares a similar disease burden to those of their overweight counterparts and should be detected early. We hypothesized that the adiponectin–leptin ratio…

Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences

Bentanachs Roger, Blanco Laia, Montesinos Maria, Sala-Vila Aleix, Lázaro Iolanda, Rodríguez-Morató Jose, Sánchez Rosa María, Laguna Juan Carlos et al. · 2023

Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of ch…

After Dinner Rest a While, After Supper Walk a Mile? A Systematic Review with Meta-analysis on the Acute Postprandial Glycemic Response to Exercise Before and After Meal Ingestion in Healthy Subjects and Patients with Impaired Glucose Tolerance.

Engeroff T, et al. · 2023

BACKGROUND: The most effective way to cope with high blood sugar spikes is to engage in physical activity in temporal proximity to food intake. However, so far, it is unclear as to whether there is an…

American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update.

Samson SL, et al. · 2023

OBJECTIVE: This consensus statement provides (1) visual guidance in concise graphic algorithms to assist with clinical decision-making of health care professionals in the management of persons with ty…

An aerobic exercise intervention to improve metabolic health among people living with HIV with at-risk alcohol use: the ALIVE-Ex research study protocol

Simon Liz, Primeaux Stefany D., Levitt Danielle E., Bourgeois Brianna, Johannsen Neil M., Peters Adrianna, Ahmed Jameel, Marshall Richard H. et al. · 2023

Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more fre…

An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice

Han Shuang, Wu Qingqian, Wang Mengying, Yang Miqi, Sun Chen, Liang Jiaqi, Guo Xiaozhen, Zhang Zheyu et al. · 2023

Exercise intervention at the early stage of type 2 diabetes mellitus (T2DM) can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular compl…

Antidepressant and antipsychotic drug prescribing and diabetes outcomes: A systematic review of observational studies.

Greene CRL, et al. · 2023

AIMS: Psychotropic medication may be associated with adverse effects, including among people with diabetes. We conducted a systematic review of observational studies investigating the association betw…

Anxiety and Depression in Early Gestation and the Association with Subsequent Gestational Diabetes Mellitus in a Disadvantaged Population.

Pathirana MM, et al. · 2023

OBJECTIVES: Evaluate the association between poor mental health and risk of developing gestational diabetes mellitus (GDM) in a cohort of women from a socioeconomically disadvantaged community. METHOD…

Artificially Sweetened Beverages and Health Outcomes: An Umbrella Review.

Diaz C, et al. · 2023

The consumption of artificially sweetened beverages (ASBs) is increasing in some countries. However, some meta-analyses have found that habitual consumers of ASBs (compared with low or no consumption)…

Association between diabetes overtreatment in older multimorbid patients and clinical outcomes: an ancillary European multicentre study.

Christiaens A, et al. · 2023

BACKGROUND: Diabetes overtreatment is a frequent and severe issue in multimorbid older patients with type 2 diabetes (T2D). OBJECTIVE: This study aimed at assessing the association between diabetes ov…

Association of Personality Traits and Self-Care Behaviors in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Dimou K, et al. · 2023

Diabetes self-care is critical for individuals with type 2 diabetes mellitus (T2DM), and exploring the impact of personality traits on this domain remains pivotal. This study aimed to investigate the …

Associations of Executive Function With Diabetes Management and Glycemic Control in Adolescents With Type 1 Diabetes.

Hansmann M, et al. · 2023

AIMS: The aims of this study were to assess domains of executive function in relation to diabetes management and glycemic control in adolescents with type 1 diabetes and to compare adolescent self-rep…

Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-analysis of Outpatient Randomized Controlled Trials.

Zeng B, et al. · 2023

BACKGROUND: The glycemic control of automated insulin delivery (AID) systems in outpatient children and adolescents with type 1 diabetes (T1D) has not been systematically evaluated. PURPOSE: To evalua…

Bariatric Surgery for Adults With Class I Obesity and Difficult-to-Manage Type 2 Diabetes: A Health Technology Assessment.

· 2023

BACKGROUND: Many individuals with type 2 diabetes are classified as either overweight or obese. A patient may be described as having difficult-to-manage type 2 diabetes if their HbA1c levels remain ab…

Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease

Becerril-Campos Adriana Araceli, Ramos-Gómez Minerva, De Los Ríos-Arellano Ericka Alejandra, Ocampo-Anguiano Perla Viridiana, González-Gallardo Adriana, Macotela Yazmín, García-Gasca Teresa, Ahumada-Solórzano Santiaga Marisela · 2023

Bioactive compounds in plant-based food have protective effects against metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). Bean leaves are widely cultivated in the world and a…

Berberine and health outcomes: An umbrella review.

Li Z, et al. · 2023

Berberine is a plant extract widely used in clinical practice. This review aimed to summarize and to grade the available evidence on the association between berberine consumption and health-related ou…

Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women

Ionescu Oana-Maria, Frincu Francesca, Mehedintu Andra, Plotogea Mihaela, Cirstoiu Monica, Petca Aida, Varlas Valentin, Mehedintu Claudia · 2023

Polycystic ovary syndrome (PCOS) is a disorder with an unknown etiology that features a wide range of endocrine and metabolic abnormalities that hamper fertility. PCOS women experience difficulties ge…

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose-Response Analysis of a Randomized Crossover Trial.

Duran AT, et al. · 2023

PURPOSE: Sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Physical activity guidelines recommend reductions in sedentary time; however, quantitativ…

Canadian Registered Dietitians' Utilization of the 2018 Diabetes Canada Nutrition Therapy Clinical Practice Guidelines: A Cross-sectional Study.

Dworatzek PDN, et al. · 2023

OBJECTIVES: Our aim in this work was to ascertain Canadian registered dietitians' (RDs) use of the 2018 Diabetes Canada nutrition therapy (NT) recommendations and to identify the degree of agreement w…

Changes in quantity plant-based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study

Gutierrez-Mariscal Francisco M., Alcalá-Diaz Juan F., Quintana-Navarro Gracia M., de la Cruz-Ares Silvia, Torres-Peña José D., Cardelo Magdalena P., Arenas-Larriva Antonio P., Malagón María M. et al. · 2023

Diabetes remission is a phenomenon described in the context of drastic weight loss due to bariatric surgery or low-calorie diets. Evidence suggests that increasing the intake of plant protein could re…

Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress.

Murray KO, et al. · 2023

Excessive reactive oxygen species production by mitochondria (mtROS) is a key contributor to age-related vascular endothelial dysfunction. We recently showed in a crossover design, placebo-controlled …

Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial.

Abbas Q, et al. · 2023

OBJECTIVE: Diabetes distress typically causes depressive symptoms; common comorbidity of diabetes unpleasantly affects patients' medical and psychological functions. Psychotherapeutic interventions ar…

Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.

Khan TA, Field D, Chen V, Ahmad S, Mejia SB, Kahleová H, Rahelić D, Salas-Salvadó J, et al. · 2023

OBJECTIVE: Combined low-risk lifestyle behaviors (LRLBs) have been associated with a reduction in type 2 diabetes risk. This relationship has not been systematically quantified. RESEARCH DESIGN AND ME…

Comparative Evaluation of a Low-Carbohydrate Diet and a Mediterranean Diet in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A 16-Week Intervention Study

Currenti Walter, Losavio Francesca, Quiete Stefano, Alanazi Amer M., Messina Giovanni, Polito Rita, Ciolli Fabiana, Zappalà Raffaela Simona et al. · 2023

Introduction: The worldwide prevalence of type 2 diabetes mellitus (T2DM) and obesity has been steadily increasing over the past four decades, with projections indicating a significant rise in the num…

Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review and network meta-analysis of randomized controlled trials.

Xia J, et al. · 2023

Medical nutrition treatment can manage diabetes and slow or prevent its complications. The comparative effects of micronutrient supplements, however, have not yet been well established. We aimed at ev…

Comparison of treatment with insulin detemir and NPH in women with gestational diabetes mellitus: glycemic control and pregnancy outcomes. A retrospective study

Kazakou Paraskevi, Paschou Stavroula A., Mitropoulou Marina, Vasileiou Vasiliki, Sarantopoulou Vasiliki, Anastasiou Eleni · 2023

The objective of this retrospective study was to compare glycemic control, pregnancy outcomes, and neonatal outcomes in women with gestational diabetes mellitus (GDM) treated with (a) insulin detemir …

Consensus Recommendations for Sick Day Medication Guidance for People With Diabetes, Kidney, or Cardiovascular Disease: A Modified Delphi Process.

Watson KE, et al. · 2023

RATIONALE & OBJECTIVE: Sick day medication guidance (SDMG) involves withholding or adjusting specific medications in the setting of acute illnesses that could contribute to complications such as hypot…

Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.

Battelino T, et al. · 2023

Randomised controlled trials and other prospective clinical studies for novel medical interventions in people with diabetes have traditionally reported HbA1c as the measure of average blood glucose le…

Correlation analysis of obesity phenotypes with leptin and adiponectin

Aisike Guliqiekeran, Kuerbanjiang Maierheba, Muheyati Dina, Zaibibuli Kaibinuer, Lv Mei-Xia, Han Jia · 2023

Obesity can be categorized as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). However, individuals with MHO are characterized by the absence of metabolic syndrome (MS) a…

Determining Dietary Patterns to Recommend for Type 2 Diabetes: An Umbrella Review.

Whiteley C, et al. · 2023

Some specific dietary patterns improve glycaemic levels and cardiovascular risk factors better than others. We aimed to identify the most effective dietary patterns using a food-focused approach to im…

Diabetic Ketoacidosis in Children and Adolescents; Diagnostic and Therapeutic Pitfalls.

Kostopoulou E, et al. · 2023

Diabetic ketoacidosis (DKA) represents an acute, severe complication of relative insulin deficiency and a common presentation of Type 1 Diabetes Mellitus (T1DM) primarily and, occasionally, Type 2 Dia…

Dietary Approach of Patients with Hormone-Related Cancer Based on the Glycemic Index and Glycemic Load Estimates

Peppa Melpomeni, Manta Aspasia, Mavroeidi Ioanna, Nastos Constantinos, Pikoulis Emmanouil, Syrigos Konstantinos, Bamias Aristotelis · 2023

Hormone-related cancers, namely breast, endometrial, cervical, prostate, testicular, and thyroid, constitute a specific group of cancers dependent on hormone levels that play an essential role in canc…

Dietary Patterns, Foods, and Nutrients to Ameliorate Non-Alcoholic Fatty Liver Disease: A Scoping Review

Montemayor Sofía, García Silvia, Monserrat-Mesquida Margalida, Tur Josep A., Bouzas Cristina · 2023

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease without pharmacological treatment yet. There is also a lack of specific dietary recommendations …

Dietary strategies in non‐alcoholic fatty liver disease patients: From evidence to daily clinical practice, a systematic review

Hadefi Alia, Arvanitakis Marianna, Trépo Eric, Zelber‐Sagi Shira · 2023

Lifestyle modification comprising calorie restriction (CR) and increased physical activity enabling weight loss is the first‐line of treatment for non‐alcoholic fatty liver disease (NAFLD). However, C…

Dietary sugar consumption and health: umbrella review.

Huang Y, et al. · 2023

OBJECTIVE: To evaluate the quality of evidence, potential biases, and validity of all available studies on dietary sugar consumption and health outcomes. DESIGN: Umbrella review of existing meta-analy…

Do glycaemic treatment targets affect the perinatal mental health status of women with gestational diabetes? - Data from the TARGET Trial.

Ohene-Agyei P, et al. · 2023

BACKGROUND: Gestational diabetes mellitus is associated with perinatal mental disorders. Effective management may reduce this risk, but there is little evidence on effects of different glycaemic treat…

Does depression increase the risk of gestational diabetes mellitus? A systematic review and meta-analysis.

Zhang C, et al. · 2023

OBJECTIVE: Data on the relationship between depression and gestational diabetes mellitus (GDM) is scarce and conflicting. We, hereby, aimed to review evidence if prior depression increases the risk of…

Early Metformin in Gestational Diabetes: A Randomized Clinical Trial.

Dunne F, et al. · 2023

IMPORTANCE: Gestational diabetes is a common complication of pregnancy and the optimal management is uncertain. OBJECTIVE: To test whether early initiation of metformin reduces insulin initiation or i…

Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

Semmler Georg, Datz Christian, Trauner Michael · 2023

Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our…

Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials

Jing Tiantian, Zhang Shunxing, Bai Mayangzong, Chen Zhongwan, Gao Sihan, Li Sisi, Zhang Jing · 2023

Background: Dietary patterns play a critical role in diabetes management, while the best dietary pattern for Type 2 diabetes (T2DM) patients is still unclear. The aim of this network meta-analysis was…

Effect of Isocaloric Meals on Postprandial Glycemic and Metabolic Markers in Type 1 Diabetes-A Randomized Crossover Trial.

Barouti AA, et al. · 2023

The aim of this study was to assess the effect of four isocaloric meals with different macronutrient compositions on postprandial blood glucose, lipids, and glucagon in adults with type 1 diabetes (T1…

Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes: A Randomized Clinical Trial.

Pavlou V, et al. · 2023

IMPORTANCE: Time-restricted eating (TRE) has become increasingly popular, yet longer-term randomized clinical trials have not evaluated its efficacy and safety in patients with type 2 diabetes (T2D). …

Effect of Yoga and Walking on Glycemic Control for the Management of Type 2 Diabetes: A Systematic Review and Meta-analysis.

Dhali B, et al. · 2023

BACKGROUND: A daily habit of yogic practice or walking, along with an oral hypoglycemic agent (OHA) could be beneficial for better control of type 2 diabetes mellitus (T2DM). We conducted a systematic…

Effect of kombucha intake on the gut microbiota and obesity-related comorbidities: A systematic review.

Costa MAC, et al. · 2023

Kombucha is a fermented nonalcoholic tea-based beverage produced through a symbiotic culture of bacteria and yeasts. In vitro studies have demonstrated antimicrobial, antioxidant, antiproliferative, a…

Effect of more versus less intensive blood pressure control on cardiovascular, renal and mortality outcomes in people with type 2 diabetes: A systematic review and meta-analysis.

Ioannidou E, et al. · 2023

BACKGROUND AND AIMS: Currently, there is uncertainty as to whether blood pressure control in patients with type 2 diabetes should be treated to standard recommended levels or more intensively. METHODS…

Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials

Dyńka Damian, Kowalcze Katarzyna, Ambrozkiewicz Filip, Paziewska Agnieszka · 2023

The exponentially growing frequency of diagnosing diabetes mellitus means that a verification of the previous dietetic approach to treating the disease seems justified. The simultaneous growth of inte…

Effects of Dairy Intake on Markers of Cardiometabolic Health in Adults: A Systematic Review with Network Meta-Analysis.

Kiesswetter E, et al. · 2023

The health effects of dairy products are still a matter of scientific debate owing to inconsistent findings across trials. Therefore, this systematic review and network meta-analysis (NMA) aimed to co…

Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review.

Hsieh RY, et al. · 2023

Alpha-lipoic acid (ALA) was found to improve the symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and ameliorating microcirculation. Our meta-a…

Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial.

Chen Y, et al. · 2023

IMPORTANCE: Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether t…

Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial

Turton Jessica L., Brinkworth Grant D., Parker Helen M., Lim David, Lee Kevin, Rush Amy, Johnson Rebecca, Rooney Kieron B. et al. · 2023

Public interest in low-carbohydrate (LC) diets for type 1 diabetes (T1D) management has increased. This study compared the effects of a healthcare professional delivered LC diet compared to habitual d…

Effects of a two meals-a-day ketogenic diet on newly diagnosed obese patients with type 2 diabetes mellitus: A retrospective observational study

Li Sumei, Yuan Shouping, Lin Guoxin, Zhang Jintian · 2023

To investigate the effects of a two-meals-a-day energy-restricted ketogenic diet (KD) on newly diagnosed obese patients with type 2 diabetes mellitus. In total, 60 obese patients with newly diagnosed …

Effects of a vegetarian diet combined with aerobic exercise on glycemic control, insulin resistance, and body composition: a systematic review and meta-analysis

Long Yi, Ye Hua, Yang Jiaming, Tao Xi, Xie Huiyong, Zhang Jiahong, Zhong Yanbiao, Wang Maoyuan · 2023

Vegetarian diets and aerobic exercise are increasingly accepted as a common way to improve lifestyle. Several studies have shown that vegetarian diets combined with aerobic exercise interventions have…

Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.

Herth J, et al. · 2023

Obstructive sleep apnoea is a highly prevalent chronic disorder and has been shown to be associated with disturbed glucose metabolism and type 2 diabetes. However, the evidence from individual clinica…

Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials.

Patikorn C, et al. · 2023

BACKGROUND: Systematic reviews and meta-analyses of randomized clinical trials (RCTs) have reported the benefits of ketogenic diets (KD) in various participants such as patients with epilepsy and adul…

Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)-A Randomized Controlled Trial.

Obermayer A, et al. · 2023

OBJECTIVE: To investigate the safety and feasibility of 3 nonconsecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated type 2 diabetes. RESEARCH DESIGN …

Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial.

Panigrahi A, et al. · 2023

BACKGROUND: Prediabetes and diabetes involve alterations in glucose homeostasis, including increased fasting blood glucose and impaired glucose tolerance. Berberine has been identified as a potential …

Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes Assessed by Retrospective Continuous Glucose Monitoring.

Zang L, et al. · 2023

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been proved a promising clinical strategy for the treatment of diabetes, and time in range (TIR) has been demonstrated a new metric of glyc…

Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes

Forouhi Nita G. · 2023

Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nutrition is now also recognised for type 2 diabetes prevention. However, the co…

Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors.

Chow E, et al. · 2023

Euglycemic diabetic ketoacidosis (EDKA) is an emerging complication of diabetes associated with an increasing use of sodium-glucose transporter type 2 (SGLT-2) inhibitor drugs. This review highlights …

Exploring the Impact of Nutrition on Non-Alcoholic Fatty Liver Disease Management: Unveiling the Roles of Various Foods, Food Components, and Compounds

Kosmalski Marcin, Frankowski Rafał, Deska Kacper, Różycka-Kosmalska Monika, Pietras Tadeusz · 2023

There is a need to introduce standardized treatment options for non-alcoholic fatty liver disease (NAFLD) due to its global prevalence and the complications of this disease. Many studies have revealed…

Fermented soybean foods and diabetes.

Hashimoto Y, et al. · 2023

The number of patients with type 2 diabetes mellitus is increasing, and its prevention and management are important. One of the factors contributing to the increased incidence of type 2 diabetes melli…

Frequently Asked Questions and Evidence-Based Answers on Medical Nutritional Therapy in Children with Type 1 Diabetes for Health Care Professionals

Eliuz Tipici Beyza, Atik Altınok Yasemin, Keser Alev · 2023

Medical nutrition therapy is a cornerstone in type 1 diabetes management and is based on the principles of healthy eating. The recommendations presented are valid for all children and their families. …

Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis.

En Li Cho E, et al. · 2023

INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with type 2 diabetes mellitus (T2DM) as a major predictor. Insulin resistance and chronic inflamm…

Glucose-lowering effects of a synbiotic combination containing Pediococcus acidilactici in C. elegans and mice

Yavorov-Dayliev Deyan, Milagro Fermín I., Ayo Josune, Oneca María, Goyache Ignacio, López-Yoldi Miguel, Aranaz Paula · 2023

Modulation of gut microbiota has emerged as a promising strategy to treat or prevent the development of different metabolic diseases, including type 2 diabetes and obesity. Previous data from our grou…

Glycemic Index and Glycemic Load Estimates in the Dietary Approach of Polycystic Ovary Syndrome

Manta Aspasia, Paschou Stavroula A., Isari Georgia, Mavroeidi Ioanna, Kalantaridou Sophia, Peppa Melpomeni · 2023

Polycystic ovary syndrome is a common endocrine disorder characterized by hormonal imbalances and various metabolic abnormalities linked to insulin resistance via a vicious cycle. Genetic and environm…

Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes.

Ben-Yacov O, et al. · 2023

OBJECTIVE: To explore the interplay between dietary modifications, microbiome composition and host metabolic responses in a dietary intervention setting of a personalised postprandial-targeting (PPT) …

High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients.

Chen L, et al. · 2023

Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities …

Hyperglycaemia following immune checkpoint inhibitor therapy-Incidence, aetiology and assessment.

Mulla K, et al. · 2023

AIMS: We systematically studied the presence of hyperglycaemia during treatment with Immune Checkpoint Inhibitors (ICPI) for cancer, in those with and without diabetes at baseline, and determined the …

Hyperglycemia Post-Influenza Vaccine in Patients With Diabetes.

Hulsizer AL, et al. · 2023

BACKGROUND: There are more than 350 reports of hyperglycemia post-influenza vaccine according to the Vaccine Adverse Effect Reporting System. Only one case report has been published detailing unusual …

Impact of a Low-Carbohydrate Compared with Low-Fat Breakfast on Blood Glucose Control in Type 2 Diabetes: A Randomized Trial.

Oliveira BF, et al. · 2023

BACKGROUND: In type 2 diabetes (T2D), consuming carbohydrates results in a rapid and large increase in blood glucose, particularly in the morning when glucose intolerance is highest. OBJECTIVES: We in…

Important denominator between autoimmune comorbidities: a review of class II HLA, autoimmune disease, and the gut

Berryman Meghan A., Ilonen Jorma, Triplett Eric W., Ludvigsson Johnny · 2023

Human leukocyte antigen (HLA) genes are associated with more diseases than any other region of the genome. Highly polymorphic HLA genes produce variable haplotypes that are specifically correlated wit…

Incidence of Diabetes in Children and Adolescents During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

D'Souza D, et al. · 2023

IMPORTANCE: There are reports of increasing incidence of pediatric diabetes since the onset of the COVID-19 pandemic. Given the limitations of individual studies that examine this association, it is i…

Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy

Tang Anqi, Zhang Yu, Wu Ling, Lin Yong, Lv Lizeyu, Zhao Liangbin, Xu Bojun, Huang Youqun et al. · 2023

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti-aging propertie…

Long-Term Consumption of Sucralose Induces Hepatic Insulin Resistance through an Extracellular Signal-Regulated Kinase 1/2-Dependent Pathway.

Tsai MJ, et al. · 2023

Sugar substitutes have been recommended to be used for weight and glycemic control. However, numerous studies indicate that consumption of artificial sweeteners exerts adverse effects on glycemic home…

Low-Carbohydrate Diet Scores and Mortality Among Adults With Incident Type 2 Diabetes.

Hu Y, et al. · 2023

OBJECTIVE: The current study aims to prospectively examine the association between postdiagnosis low-carbohydrate diet (LCD) patterns and mortality among individuals with type 2 diabetes (T2D). RESEAR…

Management of Hyperosmolar Hyperglycaemic State (HHS) in Adults: An updated guideline from the Joint British Diabetes Societies (JBDS) for Inpatient Care Group.

Mustafa OG, et al. · 2023

Hyperosmolar Hyperglycaemic State (HHS) is a medical emergency associated with high mortality. It occurs less frequently than diabetic ketoacidosis (DKA), affects those with pre-existing/new type 2 di…

Managing 'sick days' in patients with chronic conditions: An exploration of patient and healthcare provider experiences.

Dhaliwal KK, et al. · 2023

INTRODUCTION: People with chronic medical conditions often take medications that improve long-term outcomes but which can be harmful during acute illness. Guidelines recommend that healthcare provider…

Mediterranean diet and time-restricted eating as a cardiac rehabilitation approach for patients with coronary heart disease and pre-diabetes: the DIABEPIC-1 protocol of a feasibility trial

Iglesies-Grau Josep, Dionne Valérie, Latour Élise, Gayda Mathieu, Besnier Florent, Gagnon Daniel, Debray Amélie, Gagnon Christine et al. · 2023

Despite proven programmes, implementing lifestyle interventions for pre-diabetes and type 2 diabetes is challenging. Cardiac rehabilitation, provide a valuable opportunity to promote the adoption of h…

Mobile Health Intervention in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

Gerber BS, et al. · 2023

IMPORTANCE: Clinical pharmacists and health coaches using mobile health (mHealth) tools, such as telehealth and text messaging, may improve blood glucose levels in African American and Latinx populati…

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.

Panwar V, et al. · 2023

The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular ho…

Nox4 as a novel therapeutic target for diabetic vascular complications

Wang Dongxia, Li Jiaying, Luo Gang, Zhou Juan, Wang Ning, Wang Shanshan, Zhao Rui, Cao Xin et al. · 2023

Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diab…

Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention

Romero-Gómez Manuel, Zelber-Sagi Shira, Martín Franz, Bugianesi Elisabetta, Soria Bernat · 2023

Manuel Romero-Gómez and colleagues discuss how diet and modifiable factors can help prevent of non-alcoholic fatty liver disease and the importance of engaging all society through awareness, education…

Nutritional Strategies for the Management of Type 2 Diabetes Mellitus: A Narrative Review

Minari Tatiana Palotta, Tácito Lúcia Helena Bonalume, Yugar Louise Buonalumi Tácito, Ferreira-Melo Sílvia Elaine, Manzano Carolina Freitas, Pires Antônio Carlos, Moreno Heitor, Vilela-Martin José Fernando et al. · 2023

Background: Thinking about greater adherence to dietary planning, it is extremely important to be aware of all nutritional strategies and dietary prescriptions available in the literature, and of whic…

Nutritional and Exercise-Focused Lifestyle Interventions and Glycemic Control in Women with Diabetes in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Dingena Cassy F., Arofikina Daria, Campbell Matthew D., Holmes Melvin J., Scott Eleanor M., Zulyniak Michael A. · 2023

Diabetes disrupts one in six pregnancies, bestowing immediate and long-term health risks to mother and child. Diet and exercise are commonly prescribed to control dysglycemia, but their effectiveness …

Ordered Eating and Its Effects on Various Postprandial Health Markers: A Systematic Review.

Ferguson BK, et al. · 2023

OBJECTIVE: Aberrations in glucose, insulin, and other postprandial (PP) markers are common in obesity and cardiometabolic disorders. One potentially simple lifestyle/dietary modification to manage the…

Patient-reported outcomes for people with diabetes: what and how to measure? A narrative review.

Terwee CB, et al. · 2023

Patient-reported outcomes (PROs) are valuable for shared decision making and research. Patient-reported outcome measures (PROMs) are questionnaires used to measure PROs, such as health-related quality…

Patients' perspectives on screening for disordered eating among adolescents with type 1 diabetes.

Abild CB, et al. · 2023

PURPOSE: People with type 1 diabetes have an increased risk of disordered eating (DE) and eating disorders (ED). Screening is recommended however little is known about patients' perspectives on screen…

People With Diabetes Using Insulin Flying Across Multiple Time Zones: Limitations and Opportunities for Diabetes Technologies.

Huang J, et al. · 2023

Increasingly, people with diabetes (PWD) are using wearable and other devices to support self-management. During air travel, there are 4 stakeholders involved in maximizing the safety of wireless devi…

Periodontal Disease and Other Adverse Health Outcomes Share Risk Factors, including Dietary Factors and Vitamin D Status

Grant William B., van Amerongen Barbara M., Boucher Barbara J. · 2023

For nearly a century, researchers have associated periodontal disease (PD) with risks of other adverse health outcomes such as cardiovascular disease, diabetes mellitus, and respiratory diseases, as w…

Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes.

Song C, et al. · 2023

OBJECTIVE: Rather than during illness while diabetic ketoacidosis (DKA) is developing, we aimed to determine if levels of routine point-of-care capillary blood ketones could predict future DKA. RESEAR…

Postprandial dysfunction in fatty liver disease.

Grandt J, Jensen AH, Werge MP, Rashu EB, Møller A, Junker AE, Hobolth L, Mortensen C, et al. · 2023

Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important. Her…

Protein restriction for diabetic kidney disease.

Jiang S, et al. · 2023

BACKGROUND: Diabetic kidney disease (DKD) continues to be the leading cause of kidney failure across the world. For decades dietary protein restriction has been proposed for patients with DKD with the…

Psyllium is a natural nonfermented gel-forming fiber that is effective for weight loss: A comprehensive review and meta-analysis.

Gibb RD, et al. · 2023

BACKGROUND: Psyllium is a natural, predominantly soluble fiber that forms a viscous gel when hydrated and is not digested or fermented. In the small intestine, psyllium gel increases chyme viscosity, …

Quantification of insulin adherence in adults with insulin-treated type 2 diabetes: A systematic review.

Nørlev JTD, et al. · 2023

AIMS: This systematic review aims to identify current methods used for the assessment of insulin adherence in adults with insulin-treated type 2 diabetes. The primary goal is to offer recommendations …

Reducing hypoglycemia from overtreatment of type 2 diabetes in older adults: The HypoPrevent study.

Koehn DA, et al. · 2023

BACKGROUND: Hypoglycemia from overtreatment is a serious but underrecognized complication among older adults with type 2 diabetes. However, diabetes treatment is seldom deintensified. We assessed the …

Relationship between Type D personality and adverse health outcomes in people with type 2 diabetes: The parallel mediating roles of diabetes distress and social isolation.

Lee EH, et al. · 2023

AIM: To investigate the relationship between Type D personality and adverse health outcomes [glycated haemoglobin (HbA1c) and health-related quality of life (HRQOL)] directly, and indirectly via diabe…

Relationships among social support, coping style, self-stigma, and quality of life in patients with diabetic foot ulcer: A multicentre, cross-sectional study.

Luo R, et al. · 2023

Patients with diabetic foot ulcer have a significantly lower quality of life. Quality of life could be connected to other psychological or social processes. The purpose of this study was to examine th…

Remission of Type 2 Diabetes After Treatment With a High-Fiber, Low-Fat, Plant-Predominant Diet Intervention: A Case Series

Panigrahi Gunadhar, Goodwin Sally M., Staffier Kara Livingston, Karlsen Micaela · 2023

Background: Prevalence of type 2 diabetes (T2D) is rising, and its burden on the healthcare system remains a challenge. Consumption of a plant-predominant diet is a promising approach for achieving re…

Self-determination theory interventions versus usual care in people with diabetes: a systematic review with meta-analysis and trial sequential analysis.

Mathiesen AS, et al. · 2023

BACKGROUND: Autonomy-supporting interventions, such as self-determination theory and guided self-determination interventions, may improve self-management and clinical and psychosocial outcomes in peop…

Simplified Meal Announcement Versus Precise Carbohydrate Counting in Adolescents With Type 1 Diabetes Using the MiniMed 780G Advanced Hybrid Closed Loop System: A Randomized Controlled Trial Comparing Glucose Control.

Petrovski G, et al. · 2023

OBJECTIVE: We aimed to compare glucose control in adolescents with type 1 diabetes (T1D) using the MiniMed 780G system who used simplified meal announcement with those who used precise carbohydrate co…

Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization.

Song Y, et al. · 2023

BACKGROUND: Social isolation and loneliness pose significant public health challenges globally. The objective of this study is to investigate the association between social isolation, loneliness, and …

Social jet lag and (changes in) glycemic and metabolic control in people with type 2 diabetes.

Bouman EJ, et al. · 2023

OBJECTIVE: Social jet lag, i.e., the discordance among social and biological rhythms, is associated with poor metabolic control. This study aimed to assess cross-sectional and longitudinal association…

Systolic Blood Pressure Control Targets to Prevent Major Cardiovascular Events and Death in Patients With Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.

Yang Q, et al. · 2023

BACKGROUND: Previous meta-analyses using traditional pairwise comparisons did not support intensive systolic blood pressure (SBP) control in patients with diabetes and included trials published before…

Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes.

Ramos EL, et al. · 2023

BACKGROUND: Teplizumab, a humanized monoclonal antibody to CD3 on T cells, is approved by the Food and Drug Administration to delay the onset of clinical type 1 diabetes (stage 3) in patients 8 years …

The Effectiveness of Lifestyle Changes in Glycemic Control among Pregnant Women with Gestational Diabetes Mellitus

Le Duc Cuong, Vu Thanh Binh, Tran Thi Nuong, Nguyen Thi Ly, Nguyen Thanh Binh, Nguyen Duy Cuong, Hoang Van Thuan · 2023

Background and Objectives : Gestational diabetes mellitus (GDM) is a type of diabetes that develops during pregnancy and affects approximately 10% of pregnant women worldwide. Understanding the impact…

The Health Effects of Low Glycemic Index and Low Glycemic Load Interventions on Prediabetes and Type 2 Diabetes Mellitus: A Literature Review of RCTs

Peres Maria, Costa Helena S., Silva Mafalda Alexandra, Albuquerque Tânia Gonçalves · 2023

Diets with a low glycemic index (GI) and a low glycemic load (GL) can improve glycemic control, blood lipids, blood pressure and BMI in prediabetes and type 2 diabetes (T2DM), but evidence regarding o…

The Health and Functional Benefits of Eccentric versus Concentric Exercise Training: A Systematic Review and Meta-Analysis.

Ansari M, et al. · 2023

This review compared the effects of eccentric versus concentric exercise training in healthy people and people with metabolic disease. A systematic search on Cochrane Central Register of Controlled Tr…

The Influence of Ketogenic Diet on Gut Microbiota: Potential Benefits, Risks and Indications.

Santangelo A, et al. · 2023

The ketogenic diet (KD) restricts carbohydrate consumption, leading to an increase in ketone bodies, such as acetoacetate, β-hydroxybutyrate, and acetone, which are utilized as energy substrates. This…

The Influence of Real-Time Continuous Glucose Monitoring on Psychosocial Outcomes in Insulin-Using Type 2 Diabetes.

Soriano EC, et al. · 2023

BACKGROUND: To examine the impact of real-time continuous glucose monitoring (rtCGM) on psychosocial outcomes in adults with insulin-using type 2 diabetes (T2D). METHODS: A total of 174 insulin-using …

The Role of Phytochemicals and Plant-Based Diets in Gestational Diabetes: Evidence from Clinical Trials

Jaworsky Kataryna, DeVillez Pamela, Basu Arpita · 2023

Gestational diabetes mellitus (GDM) is defined as glucose intolerance identified during pregnancy. The increased risk of pregnancy complications and the adverse health effects for the mother and baby …

The artificial sweetener erythritol and cardiovascular event risk.

Witkowski M, et al. · 2023

Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythri…

The association between diabetes and safe driving: A systematic search and review of the literature and cross-reference with the current guidelines.

Maxwell H, et al. · 2023

AIMS: We conducted this review to characterize the quality of evidence about associations between diabetes and safe driving and to evaluate how these findings are reflected within current guidelines a…

The effectiveness of lifestyle interventions for diabetes remission on patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Zhang Y, et al. · 2023

BACKGROUND: Conventional wisdom affirmed that diabetes was irreversible, but current research shows that lifestyle interventions may achieve diabetes remission among patients with type 2 diabetes mell…

The effects of probiotics supplementation on glycaemic control among adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised clinical trials.

Li G, et al. · 2023

OBJECTIVE: This systematic review and meta-analysis study aimed to evaluate the effectiveness of probiotics supplementation on glycaemic control in patients with type 2 diabetes mellitus (T2DM) based …

The impact of health literacy interventions on glycemic control and self-management outcomes among type 2 diabetes mellitus: A systematic review.

Butayeva J, et al. · 2023

Diabetes imposes an increasing health and economic burden on individuals living with it and their societies worldwide. Glycemic control is necessary to reduce morbidity and mortality of type 2 diabete…

The relationship between vitamin K and T2DM: a systematic review and meta-analysis.

Qu B, et al. · 2023

Background: Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood gluc…

Transition models of care for type 1 diabetes: a systematic review.

Zurynski Y, et al. · 2023

BACKGROUND: Managing the care regimen for Type 1 Diabetes is challenging for emerging adults, as they take on greater responsibility for self-management. A diverse range of models of care have been im…

Trends in incidence of youth-onset type 1 and type 2 diabetes in the USA, 2002-18: results from the population-based SEARCH for Diabetes in Youth study.

Wagenknecht LE, et al. · 2023

BACKGROUND: The incidence of diabetes is increasing in children and young people. We aimed to describe the incidence of type 1 and type 2 diabetes in children and young people aged younger than 20 yea…

Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.

Wadwa RP, et al. · 2023

BACKGROUND: Closed-loop control systems of insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually a…

Type 2 diabetes stigma and its association with clinical, psychological, and behavioral outcomes: A systematic review and meta-analysis.

Akyirem S, et al. · 2023

AIM: To synthesize quantitative research evidence on the association between type 2 diabetes (T2D) stigma and psychological, behavioral, and clinical outcomes. METHODS: We searched APA PsycINFO, Cochr…

Use of honey in diabetic foot ulcer: Systematic review and meta-analysis.

Yildiz Karadeniz E, et al. · 2023

OBJECTIVE: The aim of this study was to evaluate the role of honey dressing as an effective intervention for diabetic foot wound management and to provide a reliable basis for future clinical study. M…

Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

Huang Hui, Luo Yayong, Wang Qian, Zhang Yihan, Li Zhongxia, He Ruikun, Chen Xiangmei, Dong Zheyi · 2023

Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence of diabetic vascular complications is also rapidly increasing, exacerbating the burd…

Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes : A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials.

Pittas AG, et al. · 2023

BACKGROUND: The role of vitamin D in people who are at risk for type 2 diabetes remains unclear. PURPOSE: To evaluate whether administration of vitamin D decreases risk for diabetes among people with …

WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.

· 2023

(abstract non disponibile su PubMed)…

WHO guideline on the use of non-sugar sweeteners: a need for reconsideration.

Khan TA, et al. · 2023

(abstract non disponibile su PubMed)…

What’s New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD)

Kosmalski Marcin, Frankowski Rafał, Ziółkowska Sylwia, Różycka-Kosmalska Monika, Pietras Tadeusz · 2023

Non-alcoholic fatty liver disease (NAFLD) is a serious health problem due to its high incidence and consequences. In view of the existing controversies, new therapeutic options for NAFLD are still bei…

Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis.

Smedegaard S, et al. · 2023

BACKGROUND: Serving whey protein before a meal in order to lower postprandial blood glucose concentrations is known as a premeal. The underlying mechanisms are only partly understood but may involve s…

Whole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation.

Li L, et al. · 2023

PURPOSE: Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident…

A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc).

Amiel SA, et al. · 2022

Impaired awareness of hypoglycaemia (IAH) is a major risk for severe hypoglycaemia in insulin treatment of type 1 diabetes (T1D). To explore the hypothesis that unhelpful health beliefs create barrier…

A systematic review and meta-analysis to compare the prevalence of depression between people with and without Type 1 and Type 2 diabetes.

Farooqi A, et al. · 2022

AIMS: Diabetes can significantly impact quality of life and mental health. However, inconsistencies have been reported in the prevalence of depression in those with Type 1 and Type 2 diabetes, and tho…

Additional insulin dosing for fat and protein in children with type 1 diabetes using multiple daily injections.

Frohock AM, et al. · 2022

OBJECTIVE: High-fat high-protein (HFHP) meals are associated with post-prandial hyperglycemia in type 1 diabetes (T1D), administration of additional insulin for such meals is recommended in order to o…

Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study.

Montemayor S, et al. · 2022

Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (Met…

Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives.

Khalid M, et al. · 2022

Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids. Glycation reaction le…

Adverse childhood experiences and risk of diabetes: A systematic review and meta-analysis.

Zhu S, et al. · 2022

BACKGROUND: The association between adverse childhood experiences (ACEs) and diabetes is unclear. This systematic review and meta-analysis aims to quantify the association between the number and types…

Aerobic or Resistance Exercise for Improved Glycaemic Control and Pregnancy Outcomes in Women with Gestational Diabetes Mellitus: A Systematic Review

Keating Niamh, Coveney Ciara, McAuliffe Fionnuala M., Higgins Mary F. · 2022

Exercise is often recommended in addition to diet and medication in the management of gestational diabetes mellitus (GDM). Our aim was to determine if strength training compared with aerobic exercise …

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.

Blonde L, et al. · 2022

OBJECTIVE: The objective of this clinical practice guideline is to provide updated and new evidence-based recommendations for the comprehensive care of persons with diabetes mellitus to clinicians, di…

Analytical interference of 33 different hemoglobin variants on HbA1c measurements comparing high-performance liquid chromatography with whole blood enzymatic assay: A multi-center study.

Zechmeister B, et al. · 2022

BACKGROUND AND AIMS: The concentration of glycated hemoglobin (HbA1c) is an essential diagnostic and therapeutic biomarker in diabetes mellitus. However, it is known that Hb structural variants and sy…

Antipsychotic-Induced Weight Gain: Dose-Response Meta-Analysis of Randomized Controlled Trials.

Wu H, et al. · 2022

BACKGROUND: Weight gain is among the most important side-effects of antipsychotics. It is, however, unclear whether it is associated with antipsychotic doses. We aimed to fill this gap with a dose-res…

Assessing barriers to insulin therapy among people with type 2 diabetes in South Africa using the Insulin Treatment Appraisal Scale: A cross-sectional survey.

Ngassa Piotie P, et al. · 2022

AIMS: To assess barriers to insulin therapy among people with type 2 diabetes after adapting the Insulin Treatment Appraisal Scale (ITAS) to the South African context. METHODS: A panel of experts revi…

Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis.

Ahmadinia AR, et al. · 2022

BACKGROUND: Several studies have assessed the relationship between type 2 diabetes (T2D) and tooth loss; however, results have been inconsistent. Therefore, the present systematic review and meta-anal…

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

Och Anna, Och Marek, Nowak Renata, Podgórska Dominika, Podgórski Rafał · 2022

In recent years, the health of patients exposed to the consequences of the metabolic syndrome still requires the search for new solutions, and plant nutraceuticals are currently being intensively inve…

Burnout Related to Diabetes Mellitus: A Critical Analysis.

Kontoangelos K, et al. · 2022

BACKGROUND: Diabetes burnout is a condition when a patient with diabetes feels tired from his/her disease and neglects it for a certain period or continuously. OBJECTIVE: Diabetes burnout is frequent,…

Carbohydrate Maldigestion and Intolerance.

Fernández-Bañares F · 2022

This review summarizes dietary carbohydrate intolerance conditions and recent advances on the possible role of carbohydrate maldigestion and dietary outcomes in patients with functional bowel disease.…

Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women.

Kazemi M, et al. · 2022

BACKGROUND: Lifestyle (dietary and/or physical activity [PA]) modification is recommended as first-line therapy to manage polycystic ovary syndrome (PCOS). Current recommendations are based on healthy…

Comparison of nutritional supplements for glycemic control in type 2 diabetes: A systematic review and network meta-analysis of randomized trials.

Kazemi A, et al. · 2022

AIMS: Direct and indirect evidence were combined in this systematic-review and network meta-analysis (NMA) to assess and compare the effect of nutritional supplements on glycemic control, and rank the…

Consumption of Dairy Products and the Risk of Overweight or Obesity, Hypertension, and Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis and Systematic Review of Cohort Studies.

Feng Y, et al. · 2022

Dairy products have been suggested to be related to the prevention of overweight or obesity, hypertension, and type 2 diabetes mellitus (T2DM). These associations are currently controversial, however,…

Correlates of Self-Reported and Functional Understanding of Nutrition Labels across 5 Countries in the 2018 International Food Policy Study.

Bhawra J, et al. · 2022

BACKGROUND: Nutrition labels on prepackaged foods are an important source of nutrition information; however, differences in comprehension of varying label formats can limit their use and effectiveness…

Could Dietary Modification Independent of Energy Balance Influence the Underlying Pathophysiology of Type 2 Diabetes? Implications for Type 2 Diabetes Remission

Guess Nicola D. · 2022

High-quality clinical trial data demonstrate that remission is possible for people living with type 2 diabetes (T2D) if they lose a large amount of weight (≥ 10 kg). Durable remission appears predicat…

Could nutrient supplements provide additional glycemic control in diabetes management? A systematic review and meta-analysis of randomized controlled trials of as an add-on nutritional supplementation therapy.

Kim Y, et al. · 2022

This systematic review and meta-analysis assessed the antidiabetic effect of pharmaconutrients as an add-on in type 2 diabetes mellitus patients by pooling data from currently available randomized con…

Culturally Tailoring Plant-Based Nutrition Interventions for Hispanic/Latino Adults at Risk for or With Type 2 Diabetes: An Integrative Review

Koh Linda M. · 2022

Introduction: Type 2 diabetes mellitus (T2DM) prevalence continues to increase among Hispanic/Latino adults. The purpose of this study was to explore and analyze literature on culturally tailored nutr…

Depression and anxiety in adolescents with type 1 diabetes and their parents.

Nguyen LA, et al. · 2022

BACKGROUND: Longitudinal studies including parental distress when examining adverse health outcomes in adolescents with type 1 diabetes are lacking. This study examined whether parental depression and…

Diabetes and Ramadan: Practical guidelines 2021.

Hassanein M, et al. · 2022

Fasting during Ramadan is one of the five pillars of Islam and is obligatory for all healthy Muslims from the age of puberty. Though individuals with some illness and serious medical conditions, inclu…

Diabetic retinopathy among type 2 diabetes mellitus patients in Sabah primary health clinics– Addressing the underlying factors

Naserrudin Nurul Athirah, Jeffree Mohammad Saffree, Kaur Nirmal, Syed Abdul Rahim Syed Sharizman, Ibrahim Mohd Yusof, Singh Kanhaiya, Singh Kanhaiya, Singh Kanhaiya · 2022

Every person diagnosed with diabetes mellitus (T2DM) is at risk of developing Diabetic retinopathy (DR). Thus, DR is one of the major chronic microvascular complications of T2DM. However, in Malaysia,…

Dietary Advice to Support Glycaemic Control and Weight Management in Women with Type 1 Diabetes during Pregnancy and Breastfeeding

Ringholm Lene, Nørgaard Sidse Kjærhus, Rytter Ane, Damm Peter, Mathiesen Elisabeth Reinhardt · 2022

In women with type 1 diabetes, the risk of adverse pregnancy outcomes, including congenital anomalies, preeclampsia, preterm delivery, foetal overgrowth and perinatal death is 2–4-fold increased compa…

Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission.

Churuangsuk C, et al. · 2022

AIMS/HYPOTHESIS: Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated die…

ESPEN micronutrient guideline.

Berger MM, et al. · 2022

BACKGROUND: Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in common pathologies, with significan…

Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial.

Salminen P, et al. · 2022

IMPORTANCE: Long-term results from randomized clinical trials comparing laparoscopic sleeve gastrectomy (LSG) with laparoscopic Roux-en-Y-gastric bypass (LRYGB) are limited. OBJECTIVE: To compare long…

Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial.

Tasali E, et al. · 2022

IMPORTANCE: Short sleep duration has been recognized as a risk factor for obesity. Whether extending sleep duration may mitigate this risk remains unknown. OBJECTIVE: To determine the effects of a sle…

Effect of a Comprehensive Telehealth Intervention vs Telemonitoring and Care Coordination in Patients With Persistently Poor Type 2 Diabetes Control: A Randomized Clinical Trial.

Crowley MJ, et al. · 2022

IMPORTANCE: Persistently poorly controlled type 2 diabetes (PPDM) is common and causes poor outcomes. Comprehensive telehealth interventions could help address PPDM, but effectiveness is uncertain, an…

Effect of a High Protein Diet at Breakfast on Postprandial Glucose Level at Dinner Time in Healthy Adults.

Xiao K, et al. · 2022

This study aimed to examine the effect of high protein breakfast diet with or without lunch on the postprandial glucose level during the day. A randomized, crossover design that recruited 12 healthy y…

Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial

Gardner Christopher D, Landry Matthew J, Perelman Dalia, Petlura Christina, Durand Lindsay R, Aronica Lucia, Crimarco Anthony, Cunanan Kristen M et al. · 2022

Consensus has not been reached on what constitutes an optimal diet in individuals with prediabetes and type 2 diabetes mellitus (T2DM), especially between low-carbohydrate options. We compared 2 low-c…

Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis.

Jansson AK, et al. · 2022

Type 2 diabetes mellitus (T2DM) accounts for approximately 90% of diabetes cases globally. Regular physical activity is regarded as one of the key components in T2DM management. Aerobic exercise was t…

Effects of a Low-Carbohydrate Dietary Intervention on Hemoglobin A 1c

Dorans Kirsten S., Bazzano Lydia A., Qi Lu, He Hua, Chen Jing, Appel Lawrence J., Chen Chung-Shiuan, Hsieh Ming-Hui et al. · 2022

What is the effect of a dietary intervention promoting a low-carbohydrate diet compared with usual diet on 6-month change in hemoglobin A 1c among adults with untreated hemoglobin A 1c of 6.0% to 6.9%…

Effects of the Ketogenic Diet on Muscle Hypertrophy in Resistance-Trained Men and Women: A Systematic Review and Meta-Analysis.

Vargas-Molina S, et al. · 2022

Reviews focused on the ketogenic diet (KD) based on the increase in fat-free mass (FFM) have been carried out with pathological populations or, failing that, without population differentiation. The ai…

Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis.

Tan HC, et al. · 2022

BACKGROUND: The weight loss benefit of semaglutide in patients with diabetes is well-documented, but its clinical utility in treating obesity among patients without diabetes is less described. We ther…

Efficacy and safety of carbohydrate counting versus other forms of dietary advice in patients with type 1 diabetes mellitus: a systematic review and meta-analysis of randomised clinical trials.

Builes-Montaño CE, et al. · 2022

BACKGROUND AND AIMS: Diabetes mellitus (DM) is one of the most prevalent chronic noncommunicable diseases globally, and the only way to reduce its complications is good glycaemic control. Insulin rema…

Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta-analysis.

Lin T, et al. · 2022

AIMS/INTRODUCTION: The optimal therapy for latent autoimmune diabetes in adults (LADA) remains undefined. Increasing evidence has shown that sitagliptin and insulin treatment can benefit patients with…

Efficacy of insulin dosing algorithms for high-fat high-protein mixed meals to control postprandial glycemic excursions in people living with type 1 diabetes: A systematic review and meta-analysis.

Al Balwi R, et al. · 2022

Optimizing postprandial blood glucose (PPG) levels after mixed meals that contain high fat and protein remains a challenge in the treatment of type 1 diabetes. This study evaluated the efficacy of dif…

Exercise and Neuropathy: Systematic Review with Meta-Analysis.

Streckmann F, et al. · 2022

INTRODUCTION: Peripheral neuropathies are a prevalent, heterogeneous group of diseases of the peripheral nervous system. Symptoms are often debilitating, difficult to treat, and usually become chronic…

Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends

Behl Tapan, Singh Sukhbir, Sharma Neelam, Zahoor Ishrat, Albarrati Ali, Albratty Mohammed, Meraya Abdulkarim M., Najmi Asim et al. · 2022

Traditionally, herbal compounds have been the focus of scientific interest for the last several centuries, and continuous research into their medicinal potential is underway. Berberine (BBR) is an iso…

Exploring the Path of Mediterranean Diet, Non-Alcoholic Fatty Liver Disease (NAFLD) and Inflammation towards 10-Year Cardiovascular Disease (CVD) Risk: The ATTICA Study 10-Year Follow-Up (2002–2012)

George Elena S., Georgousopoulou Ekavi N., Mellor Duane D., Chrysohoou Christina, Pitsavos Christos, Panagiotakos Demosthenes B. · 2022

Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease, affecting ~30% of the population and increasing CVD. This study aimed to explore the direct, indirect and c…

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions.

Li JX, et al. · 2022

Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and immunosuppressive therapeutics in the 1940s and their continued use and development have successfully revolutionized…

Fructose malabsorption: causes, diagnosis and treatment.

Benardout M, et al. · 2022

This review intends to act as an overview of fructose malabsorption (FM) and its role in the aetiology of diseases including, but not limited to, irritable bowel syndrome (IBS) and infantile colic and…

GLP-1a: Going beyond Traditional Use.

Laurindo LF, et al. · 2022

Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and obesity. However, t…

Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.

Ye W, et al. · 2022

OBJECTIVE: To investigate the association between gestational diabetes mellitus and adverse outcomes of pregnancy after adjustment for at least minimal confounding factors. DESIGN: Systematic review a…

Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic Review.

Brooks D, et al. · 2022

OBJECTIVE: Optimal glucocorticoid-induced hyperglycemia (GCIH) management is unclear. The COVID-19 pandemic has made this issue more prominent because dexamethasone became the standard of care in pati…

Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.

, et al. · 2022

BACKGROUND: Data are lacking on the comparative effectiveness of commonly used glucose-lowering medications, when added to metformin, with respect to microvascular and cardiovascular disease outcomes …

Glycemic Control and Diabetes Related Complications in Adults with Type 1 Diabetes Mellitus and ADHD.

Vinker-Shuster M, et al. · 2022

OBJECTIVE: To assess the correlation of co-morbid ADHD and diabetes-related complications in patients with type-1-diabetes-mellitus (T1DM). METHODS: A retrospective cross-sectional study was conducted…

Glycemic index and glycemic load of common fruit juices in Thailand

Visuthranukul Chonnikant, Sampatanukul Pichet, Aroonparkmongkol Suphab, Sirimongkol Pathama, Chomtho Sirinuch · 2022

The glycemic index (GI) reflects body responses to different carbohydrate-rich foods. Generally, it cannot be simply predicted from the composition of the food but needs in vivo testing. Healthy adult…

Glycemic response, satiety, gastric secretions and emptying after bread consumption with water, tea or lemon juice: a randomized crossover intervention using MRI.

Freitas D, et al. · 2022

PURPOSE: Numerous studies, including our previous work with lemon juice, have reported that low-pH meals reduce the glycemic response to starchy foods. However, the underlying mechanism is not yet und…

Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis.

Portincasa P, et al. · 2022

Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and relate…

Gut microbiome and health: mechanistic insights.

de Vos WM, et al. · 2022

The gut microbiota is now considered as one of the key elements contributing to the regulation of host health. Virtually all our body sites are colonised by microbes suggesting different types of cros…

ISPAD Clinical Practice Consensus Guidelines 2022: Assessment and management of hypoglycemia in children and adolescents with diabetes.

Abraham MB, et al. · 2022

(abstract non disponibile su PubMed)…

ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes in adolescence.

Gregory JW, et al. · 2022

(abstract non disponibile su PubMed)…

ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes.

Adolfsson P, et al. · 2022

(abstract non disponibile su PubMed)…

ISPAD Clinical Practice Consensus Guidelines 2022: Glycemic targets and glucose monitoring for children, adolescents, and young people with diabetes.

de Bock M, et al. · 2022

(abstract non disponibile su PubMed)…

ISPAD Clinical Practice Consensus Guidelines 2022: Nutritional management in children and adolescents with diabetes.

Annan SF, et al. · 2022

Linea guida ISPAD 2022 sulla gestione NUTRIZIONALE di bambini e adolescenti con diabete, tipo 1 e tipo 2. La terapia nutrizionale e' raccomandata per ogni bambino con diabete ed e' compito di un dieti…

ISPAD Clinical Practice Consensus Guidelines 2022: Psychological care of children, adolescents and young adults with diabetes.

de Wit M, et al. · 2022

(abstract non disponibile su PubMed)…

ISPAD Clinical Practice Consensus Guidelines 2022: Type 2 diabetes in children and adolescents.

Shah AS, et al. · 2022

Since the 2018 ISPAD guidelines on this topic, follow-up of large cohorts from around the globe have continued informing the current incidence and prevalence of co-morbidities and complications in you…

Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.

, et al. · 2022

BACKGROUND: Large trials have shown that sodium glucose co-transporter-2 (SGLT2) inhibitors reduce the risk of adverse kidney and cardiovascular outcomes in patients with heart failure or chronic kidn…

Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials

Lee Danielle, Chiavaroli Laura, Ayoub-Charette Sabrina, Khan Tauseef A., Zurbau Andreea, Au-Yeung Fei, Cheung Annette, Liu Qi et al. · 2022

Background: Fructose providing excess calories in the form of sugar sweetened beverages (SSBs) increases markers of non-alcoholic fatty liver disease (NAFLD). Whether this effect holds for other impor…

Intensive sick day rules to prevent recurrent diabetic ketoacidosis- An intervention that exemplifies health disparities.

Dye AM, et al. · 2022

OBJECTIVE: Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes (T1D). In established T1D patients, DKA is frequently a result of insulin omissi…

Intermittent fasting and exercise therapy abates STZ‐induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway

Chijiokwu Ejime A., Nwangwa Eze K., Oyovwi Mega O., Naiho Alexander O., Emojevwe Victor, Ohwin Ejiro P., Ehiwarior Prosper A., Ojugbeli Evelyn T. et al. · 2022

Diabetes is a global, costly, and growing public health issue. Intermittent fasting (IF) and exercise therapy have been shown to improve insulin sensitivity (IS) in large studies, although the underly…

Intra-pancreatic fat deposition: bringing hidden fat to the fore.

Petrov MS, et al. · 2022

Development of advanced modalities for detection of fat within the pancreas has transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and disease. There is now stro…

Investigating the Effectiveness of Very Low-Calorie Diets and Low-Fat Vegan Diets on Weight and Glycemic Markers in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Kashyap Anjali, Mackay Alexander, Carter Ben, Fyfe Claire L., Johnstone Alexandra M., Myint Phyo K. · 2022

Caloric restriction and vegan diets have demonstrated protective effects for diabetes, however their role in improving clinically relevant outcomes has not been summarized. Our aim was to evaluate the…

Italian Ketogenic Mediterranean Diet in Overweight and Obese Patients with Prediabetes or Type 2 Diabetes

Ivan Cincione Raffaele, Messina Antonietta, Cibelli Giuseppe, Messina Giovanni, Polito Rita, Losavio Francesca, Torre Ester La, Monda Vincenzo et al. · 2022

Obesity is a multifactorial disease strongly associated with insulin resistance and/or type 2 diabetes mellitus. Correct nutrition represents a valid strategy to fight these dysmetabolic pathologies r…

Job strain and effort-reward imbalance as risk factors for type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies.

Pena-Gralle APB, et al. · 2022

OBJECTIVES: This systematic review and meta-analysis aimed to synthesize the available data on prospective associations between work-related stressors and the risk of type 2 diabetes mellitus (T2DM) a…

Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails

Zhou Chong, Wang Meng, Liang Jiling, He Guomin, Chen Ning · 2022

A ketogenic diet, characterized by low calories with high levels of fat, adequate levels of protein, and low levels of carbohydrates, has beneficial effects on body weight control in overweight patien…

Leptin Signaling in Obesity and Colorectal Cancer

Socol Claudia Terezia, Chira Alexandra, Martinez-Sanchez Maria Antonia, Nuñez-Sanchez Maria Angeles, Maerescu Cristina Maria, Mierlita Daniel, Rusu Alexandru Vasile, Ruiz-Alcaraz Antonio Jose et al. · 2022

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the world, showing a complex multifactorial pathology. Obesity is considered a risk factor in CRC development throu…

Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis

Kleissl-Muir Sabine, Rasmussen Bodil, Owen Alice, Zinn Caryn, Driscoll Andrea · 2022

Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiom…

Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A randomized crossover trial.

Algera JP, et al. · 2022

BACKGROUND & AIMS: Fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) can provoke symptoms in patients with irritable bowel syndrome (IBS). We aimed to compare the effects of diets with lo…

Low-carbohydrate vegan diets in diabetes for weight loss and sustainability: a randomized controlled trial.

Jenkins DJ, et al. · 2022

BACKGROUND: Low-carbohydrate, high animal fat and protein diets have been promoted for weight loss and diabetes treatment. We therefore tested the effect of a low-carbohydrate vegan diet in diabetes a…

Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk.

Naude CE, et al. · 2022

BACKGROUND: Debates on effective and safe diets for managing obesity in adults are ongoing. Low-carbohydrate weight-reducing diets (also known as 'low-carb diets') continue to be widely promoted, mark…

Management of Hyperglycemia in Hospitalized Adult Patients in Non-Critical Care Settings: An Endocrine Society Clinical Practice Guideline.

Korytkowski MT, et al. · 2022

BACKGROUND: Adult patients with diabetes or newly recognized hyperglycemia account for over 30% of noncritically ill hospitalized patients. These patients are at increased risk for adverse clinical ou…

Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Davies MJ, et al. · 2022

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on the management of hyperglycemia in type 2 diabe…

Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis.

Karagiannis T, et al. · 2022

AIMS/HYPOTHESIS: Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Indiv…

Meal Timing, Meal Frequency and Metabolic Syndrome.

Alkhulaifi F, et al. · 2022

Individuals with metabolic syndrome have increased risk for developing health conditions, including cardiovascular diseases and stroke. Modifiable risk factors, such as exercise and diet, are key comp…

Mediterranean Diet: A Tool to Break the Relationship of Atrial Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

Biccirè Flavio Giuseppe, Bucci Tommaso, Menichelli Danilo, Cammisotto Vittoria, Pignatelli Pasquale, Carnevale Roberto, Pastori Daniele · 2022

Atrial fibrillation (AF) is the most common supraventricular arrhythmia associated with increased cardiovascular and non-cardiovascular morbidity and mortality. As multiple factors may predispose the …

Metabolomic signatures after bariatric surgery - a systematic review.

Vaz M, et al. · 2022

Metabolomics emerged as an important tool to gain insights on how the body responds to therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity and obesity-relat…

Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport.

Herman R, et al. · 2022

Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a wel…

Micronutrient Supplementation to Reduce Cardiovascular Risk.

An P, et al. · 2022

BACKGROUND: Healthy dietary patterns are rich in micronutrients, but their influence on cardiovascular disease (CVD) risks has not been systematically quantified. OBJECTIVES: The goal of this study wa…

Nutrition and physical activity: An Obesity Medicine Association (OMA) Clinical Practice Statement 2022

Alexander Lydia, Christensen Sandra M., Richardson Larry, Ingersoll Amy Beth, Burridge Karli, Golden Angela, Karjoo Sara, Cortez Danielle et al. · 2022

This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) on Nutrition and Physical Activity provides clinicians an overview of nutrition and physical activity principles applicable to…

Once-Weekly Semaglutide in Adolescents with Obesity.

Weghuber D, et al. · 2022

BACKGROUND: A once-weekly, 2.4-mg dose of subcutaneous semaglutide, a glucagon-like peptide-1 receptor agonist, is used to treat obesity in adults, but assessment of the drug in adolescents has been l…

Optimal Prandial Timing of Insulin Bolus in Youths with Type 1 Diabetes: A Systematic Review.

Mozzillo E, et al. · 2022

The aim of this systematic review was to report the evidence on optimal prandial timing of insulin bolus in youths with type 1 diabetes. A systematic search was performed including studies published i…

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance.

Suez J, et al. · 2022

Non-nutritive sweeteners (NNS) are commonly integrated into human diet and presumed to be inert; however, animal studies suggest that they may impact the microbiome and downstream glycemic responses. …

Postprandial Glycemic Response to Whole Fruit versus Blended Fruit in Healthy, Young Adults.

Crummett LT, et al. · 2022

While increased intake of dietary fiber is known to reduce postprandial glycemic response, it is less understood whether the disruption of dietary fiber, in a blender, alters the postprandial glycemic…

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.

Krischer JP, et al. · 2022

OBJECTIVE: To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS:…

Prevalence and Risk Factors of Postpartum Depression in Women: A Systematic Review and Meta-analysis.

Liu X, et al. · 2022

AIM: The current systematic review aimed to present the pooled estimated prevalence and risk factors of PPD. BACKGROUND: Postpartum depression seriously affects the physical and mental health of the m…

Prevalence and Risk Factors of Sarcopenia in Patients With Diabetes: A Meta-analysis.

Feng L, et al. · 2022

CONTEXT: The prevalence of sarcopenia in patients with diabetes is 3 times higher than that in patients without diabetes and is associated with a poor prognosis. OBJECTIVE: To investigate the global p…

Prevalence and impact of polypharmacy in older patients with type 2 diabetes.

Remelli F, et al. · 2022

BACKGROUND: Polypharmacy is a prevalent condition in older adults, especially those with multiple chronic diseases, and has been largely associated with adverse outcomes, including disability, hospita…

Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews.

Lindekilde N, et al. · 2022

AIMS/HYPOTHESIS: Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical apprais…

Racial differences in psychological stress and insulin sensitivity in non-Hispanic Black and White adolescents with overweight/obesity.

Ajibewa TA, et al. · 2022

INTRODUCTION: Racial differences in type 2 diabetes risk persist among non-Hispanic Black and non-Hispanic White adolescents with overweight/obesity; however, the role of psychological stress in this …

Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.

Mahjabeen W, et al. · 2022

OBJECTIVE: The objective was to determine the effects of resveratrol supplementation on glucose homeostasis, oxidative stress, inflammation and microRNAs expression in patients with diabetes mellitus …

Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force.

Jonas DE, et al. · 2022

IMPORTANCE: Of youths diagnosed with type 2 diabetes, many develop microvascular complications by young adulthood. OBJECTIVE: To review the evidence on benefits and harms of screening children and ado…

Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.

Ziegler D, et al. · 2022

Diabetic sensorimotor polyneuropathy (DSPN) affects around one third of people with diabetes and accounts for considerable morbidity, increased risk of mortality, reduced quality of life, and increase…

Severe Mental Illness and the Risk of Diabetes Complications: A Nationwide, Register-based Cohort Study.

Scheuer SH, et al. · 2022

CONTEXT: Individuals with severe mental illness (SMI) are at increased risk of developing type 2 diabetes. OBJECTIVE: This work explores whether individuals with diabetes and SMI are also at increased…

Severe mental illness and quality of care for type 2 diabetes: A retrospective population-based cohort study.

Scheuer SH, et al. · 2022

AIMS: To compare quality of care for type 2 diabetes in people with severe mental illness (SMI) versus no mental illness. METHODS: We used routinely collected linked data to create a retrospective coh…

Sick Day Medication Guidance for People With Diabetes, Kidney Disease, or Cardiovascular Disease: A Systematic Scoping Review.

Watson KE, et al. · 2022

RATIONALE & OBJECTIVE: Sick day medication guidance has been promoted to prevent adverse events for people with chronic conditions. Our aim was to summarize the existing sick day medication guidance a…

Stigma evaluation for diabetes and other chronic non-communicable disease patients: Development, validation and clinical use of stigma scale - The Kanden Institute Stigma Scale.

Tanaka N, et al. · 2022

AIMS/INTRODUCTION: The aim of this study was to develop a scale to evaluate disease stigma in patients with lifestyle-related chronic non-communicable diseases (LCNCDs), which we named the Kanden Inst…

Systematic Review of the Effect on Caries of Sugars Intake: Ten-Year Update.

Moores CJ, et al. · 2022

An update of the systematic review of evidence on the association between amount of sugars intake and dental caries, as well as on the effect of restricting sugars intake to <10% and <5% energy (E) on…

Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults.

Méndez-García LA, et al. · 2022

Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models. However, there are no conclusive studies in humans. Our goals were to examine the effect of sucralose consumption o…

The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis.

Buffey AJ, et al. · 2022

BACKGROUND: Increasing evidence highlights that accumulating sitting time in prolonged bouts is detrimental to cardiometabolic health. OBJECTIVES: This systematic review aimed to compare the effects o…

The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy—A Review of the Literature

Bryl Anna, Mrugacz Małgorzata, Falkowski Mariusz, Zorena Katarzyna · 2022

Diabetes is a major social problem. As shown by epidemiological studies, the world incidence of diabetes is increasing and so is the number of people suffering from its complications. Therefore, it is…

The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals

Khodarahmi Mahdieh, Siri Goli, Mohammadi Mohaddeseh, Farhangi Mahdieh Abbasalizad, Aleseidi Samira · 2022

The association of genetic and dietary factors with occurrence and progression of chronic diseases such as metabolic syndrome (MetS) has long been addressed but there is a lack of evidence for complex…

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

Winiarska-Mieczan Anna, Tomaszewska Ewa, Donaldson Janine, Jachimowicz Karolina · 2022

Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in the alleviation o…

The effect of family-based intervention for adults with diabetes on HbA1c and other health-related outcomes: Systematic review and meta-analysis.

Zhang H, et al. · 2022

AIMS AND OBJECTIVES: To evaluate the effectiveness of family-based intervention for adults with diabetes on glycosylated haemoglobin and other health-related outcomes. BACKGROUND: The impact of family…

The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials.

Paul P, et al. · 2022

AIM/HYPOTHESIS: The globally escalating diabetes epidemic is responsible for significant morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated for their potential to res…

The effect of periodic ketogenic diet on newly diagnosed overweight or obese patients with type 2 diabetes

Li Sumei, Lin Guoxin, Chen Jinxing, Chen Zhenxin, Xu Feipeng, Zhu Feng, Zhang Jintian, Yuan Shouping · 2022

The ketogenic diet (KD) is characterized by fat as a substitute of carbohydrates for the primary energy source. There is a large number of overweight or obese people with type 2 diabetes mellitus (T2D…

The efficacy of vitamin B12 supplementation for treating vitamin B12 deficiency and peripheral neuropathy in metformin-treated type 2 diabetes mellitus patients: A systematic review.

Pratama S, et al. · 2022

BACKGROUND AND AIMS: Metformin-treated type 2 diabetes mellitus (T2DM) patients are at higher risk of vitamin B12 deficiency and more severe neuropathy symptoms. There is still no guideline suggesting…

The interplay between diabetes mellitus and menopause: clinical implications.

Lambrinoudaki I, et al. · 2022

The menopausal transition is an impactful period in women's lives, when the risk of cardiovascular disease is accelerated. Similarly, diabetes mellitus profoundly impacts cardiovascular risk. However,…

The prevalence and characteristics of alexithymia in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Pei JH, et al. · 2022

BACKGROUND: Alexithymia is common in patients with type 2 diabetes mellitus (T2DM). Although the estimated prevalence of alexithymia in patients with T2DM is widely reported, these results have not be…

The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis.

Ai Y, et al. · 2022

BACKGROUND: This study aims to investigate the prevalence estimate of diabetes mellitus (DM) among people with attention deficit hyperactivity disorder (ADHD) as well as the prevalence of ADHD among t…

Transition from pediatric to adult care in type 1 diabetes mellitus: a longitudinal analysis of age at transfer and gap in care.

Soliman D, et al. · 2022

INTRODUCTION: Adolescents and young adults (AYAs) with type 1 diabetes (T1D) are at risk of suboptimal glycemic control and high acute care utilization. Little is known about the optimal age to transf…

Traveling Across Time Zones With Type 1 Diabetes: A Pilot Study Comparing Insulin Degludec With Insulin Glargine U100.

Bevier WC, et al. · 2022

OBJECTIVE: For people with type 1 diabetes, there are limited evidence-based resources to support self-management when traveling across multiple time zones. Here, we compared glycemic control on insul…

Treatment of periodontitis for glycaemic control in people with diabetes mellitus.

Simpson TC, et al. · 2022

BACKGROUND: Glycaemic control is a key component in diabetes mellitus (diabetes) management. Periodontitis is the inflammation and destruction of the underlying supporting tissues of the teeth. Some s…

Type 2 diabetes and bone fragility in children and adults.

Faienza MF, et al. · 2022

Type 2 diabetes (T2D) is a global epidemic disease. The prevalence of T2D in adolescents and young adults is increasing alarmingly. The mechanisms leading to T2D in young people are similar to those i…

Very low carbohydrate (ketogenic) diets in type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

Parry‐Strong Amber, Wright‐McNaughton Morag, Weatherall Mark, Hall Rosemary M., Coppell Kirsten J., Barthow Christine, Krebs Jeremy D. · 2022

Very low carbohydrate/ketogenic diets (VLC/KDs) are popular but their role in managing pre‐diabetes and type 2 diabetes (T2D) is uncertain. This study uses a systematic review and meta‐analysis of ran…

Wegovy (semaglutide): a new weight loss drug for chronic weight management.

Singh G, et al. · 2022

Obesity is a growing epidemic within the USA. Because weight gain is associated with an increased risk of developing life-threatening comorbidities, such as hypertension or type 2 diabetes, there is g…

When therapeutic drugs lead to diabetes.

Fève B, et al. · 2022

Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances bec…

A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial.

Burén J, et al. · 2021

Ketogenic low-carbohydrate high-fat (LCHF) diets are popular among young, healthy, normal-weight individuals for various reasons. We aimed to investigate the effect of a ketogenic LCHF diet on low-den…

A Pilot Study on the Metabolic Impact of Mediterranean Diet in Type 2 Diabetes: Is Gut Microbiota the Key?

Ismael Shámila, Silvestre Marta P., Vasques Miguel, Araújo João R., Morais Juliana, Duarte Maria Inês, Pestana Diogo, Faria Ana et al. · 2021

The Mediterranean diet (MD) has been recommended for type 2 diabetes (T2D) treatment. The impact of diet in shaping the gut microbiota is well known, particularly for MD. However, the link between MD …

A Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Fingerstick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes.

· 2021

OBJECTIVE: This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes and parental…

Acute Metabolic Emergencies in Diabetes: DKA, HHS and EDKA.

Muneer M, et al. · 2021

Emergency admissions due to acute metabolic crisis in patients with diabetes remain some of the most common and challenging conditions. DKA (Diabetic Ketoacidosis), HHS (Hyperglycaemic Hyperosmolar St…

Adapting Medication for Type 2 Diabetes to a Low Carbohydrate Diet.

Cucuzzella M, et al. · 2021

Healthcare professionals in the primary care setting need to be competent to safely adapt diabetes medications when patients with Type 2 Diabetes (T2D) alter their diet. Safe prescribing practice is s…

Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?

Shoshan-Barmatz Varda, Anand Uttpal, Nahon-Crystal Edna, Di Carlo Marta, Shteinfer-Kuzmine Anna · 2021

Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range of other …

Akkermansia , a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar

Lakshmanan Arun Prasath, Kohil Amira, El Assadi Farah, Al Zaidan Sara, Al Abduljabbar Shaikha, Bangarusamy Dhinoth Kumar, Al Khalaf Fawziya, Petrovski Goran et al. · 2021

In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) thera…

Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer

Rajesh Yetirajam, Sarkar Devanand · 2021

Obesity is rapidly dispersing all around the world and is closely associated with a high risk of metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease (NAFL…

Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study

Drummen Mathijs, Adam Tanja C, Macdonald Ian A, Jalo Elli, Larssen Thomas M, Martinez J Alfredo, Handjiev-Darlenska Teodora, Brand-Miller Jennie et al. · 2021

Observed associations of high-protein diets with changes in insulin resistance are inconclusive. We aimed to assess associations of changes in both reported and estimated protein (P Rep ; P Est ) and …

Benefits of continuous positive airway pressure on glycaemic control and insulin resistance in patients with type 2 diabetes and obstructive sleep apnoea: A meta-analysis.

Shang W, et al. · 2021

AIM: To conduct a meta-analysis to determine the effects of continuous positive airway pressure (CPAP) treatment on glycaemic control and insulin resistance in patients with type 2 diabetes and obstru…

Benefits of pulse consumption on metabolism and health: A systematic review of randomized controlled trials.

Ferreira H, et al. · 2021

Pulses are nutrient-dense foods that have for a long time been empirically known to have beneficial effects in human health. In the last decade, several studies have gathered evidence of the metabolic…

Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies.

Stöhr J, et al. · 2021

Periodontal disease has been reported to be associated with diabetes mellitus. However, the direction of the association and the influence of bias are not clear. Thus, the aim of this systematic revie…

Both Isocarbohydrate and Hypercarbohydrate Fruit Preloads Curbed Postprandial Glycemic Excursion in Healthy Subjects.

Lu X, et al. · 2021

This study aimed to investigate the impact of fruit preloads on the acute postprandial glycemic response (PGR) and satiety response of a rice meal in healthy female subjects based on iso-carbohydrate …

Cellular and Molecular Mechanisms of Metformin Action.

LaMoia TE, et al. · 2021

Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been s…

Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial

Tian Ying, Zhang Suhan, Huang Feiling, Ma Liangkun · 2021

Gestational diabetes mellitus (GDM) can usually be well controlled by health education and lifestyle management, resulting in better pregnancy outcomes. However, standard clinical prenatal care, which…

Development and validation of a scale to measure diabetes burnout.

Abdoli S, et al. · 2021

INTRODUCTION: The aim of this study is to establish reliability and validity of the Diabetes Burnout Scale (DBS) among adults with type 1 diabetes (T1D). METHODS: We used a multi-stage, mixed methods …

Diabetes distress instruments in adults with Type 1 diabetes: A systematic review using the COSMIN (COnsensus-based Standards for the selection of health status Measurement INstruments) checklist.

Kenny E, et al. · 2021

AIMS: To identify all extant instruments used to measure diabetes distress in adults with Type 1 diabetes and to evaluate the evidence for the measurement properties of these instruments. METHODS: Med…

Diabetes following acute pancreatitis.

Hart PA, et al. · 2021

Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this con…

Dietary Intake and Adherence to the Recommendations for Healthy Eating in Patients With Type 1 Diabetes: A Narrative Review.

Pancheva R, et al. · 2021

Background: Medical nutrition therapy is essential for all people with diabetes, of any type or severity. Compliance with the recommended nutrition is an integral part of the treatment of type 1 diabe…

Dietary glycemic index, glycemic load, and endometrial cancer risk: The Japan Public Health Center‐based Prospective Study

Watanabe Yuya, Katagiri Ryoko, Goto Atsushi, Shimazu Taichi, Yamaji Taiki, Sawada Norie, Iwasaki Motoki, Inoue Manami et al. · 2021

Evidence supporting the association of glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer is controversial and reports from Asia were limited. Therefore, we aimed to invest…

Dietary management practices for type 1 diabetes mellitus by dietitians in KwaZulu-Natal

Dimitriades Megan E., Pillay Kirthee · 2021

In South Africa, 5% – 15% of diabetics have type 1 diabetes mellitus (T1DM). Dietitians are an important part of the diabetes management team; however, there is a lack of published data on the dietary…

Differential loss of β-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study.

Utzschneider KM, et al. · 2021

AIMS: To compare OGTT-derived estimates of β-cell function between youth and adults with impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes after treatment discontinuation in RISE.…

Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk

Hassler Eva Maria, Deutschmann Hannes, Almer Gunter, Renner Wilfried, Mangge Harald, Herrmann Markus, Leber Stefan, Michenthaler Manuela et al. · 2021

Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between the amount of subcutaneous adipose tissue (SAT) and higher serum a…

Does exercise improve healing of diabetic foot ulcers? A systematic review.

Tran MM, et al. · 2021

BACKGROUND: For patients with diabetic foot ulcers, offloading is one crucial aspect of treatment and aims to redistribute pressure away from the ulcer site. In addition to offloading strategies, pati…

Dysbiosis in the Development of Type I Diabetes and Associated Complications: From Mechanisms to Targeted Gut Microbes Manipulation Therapies

Gradisteanu Pircalabioru Gratiela, Corcionivoschi Nicolae, Gundogdu Ozan, Chifiriuc Mariana-Carmen, Marutescu Luminita Gabriela, Ispas Bogdan, Savu Octavian · 2021

Globally, we are facing a worrying increase in type 1 diabetes mellitus (T1DM) incidence, with onset at younger age shedding light on the need to better understand the mechanisms of disease and step-u…

Early versus delayed insulin pump therapy in children with newly diagnosed type 1 diabetes: results from the multicentre, prospective diabetes follow-up DPV registry.

Kamrath C, et al. · 2021

BACKGROUND: Although continuous subcutaneous insulin infusion therapy (ie, insulin pump therapy) is associated with improved metabolic control compared with multiple daily insulin injections in childr…

Ecological momentary assessment for health behaviors and contextual factors in persons with diabetes: A systematic review.

Nam S, et al. · 2021

AIM: The objective of this systematic review was to summarize the ecological momentary assessment (EMA) methodology and associations between EMA-measured psychosocial, contextual factors and diabetes …

Effect of Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes Treated With Basal Insulin: A Randomized Clinical Trial.

Martens T, et al. · 2021

IMPORTANCE: Continuous glucose monitoring (CGM) has been shown to be beneficial for adults with type 2 diabetes using intensive insulin therapy, but its use in type 2 diabetes treated with basal insul…

Effect of a Hybrid Closed-Loop System on Glycemic and Psychosocial Outcomes in Children and Adolescents With Type 1 Diabetes: A Randomized Clinical Trial.

Abraham MB, et al. · 2021

IMPORTANCE: Hybrid closed-loop (HCL) therapy has improved glycemic control in children and adolescents with type 1 diabetes; however, the efficacy of HCL on glycemic and psychosocial outcomes has not …

Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials.

Chiavaroli L, et al. · 2021

OBJECTIVE: To inform the update of the European Association for the Study of Diabetes clinical practice guidelines for nutrition therapy. DESIGN: Systematic review and meta-analysis of randomised cont…

Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis.

Cherubini V, et al. · 2021

AIM: To determine if diabetes awareness campaigns are an effective intervention to reduce diabetes ketoacidosis at diagnosis of type 1 diabetes in children and youth. METHODS: Search strategies includ…

Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mason SA, et al. · 2021

BACKGROUND: Evidence suggests that vitamin C supplementation could be a potential therapy in type 2 diabetes. However, its effectiveness and evidence quality require further evaluation. PURPOSE: To in…

Effects of incretin-based therapies on β-cell function in type 1 diabetes mellitus: a systematic review and meta-analysis.

Wu Y, et al. · 2021

AIM: To assess the effects of incretin-based therapies on β-cell function in patients with type 1 diabetes mellitus (T1DM). METHODS: We searched the PubMed, Cochrane Library, Embase, and Web of Knowle…

Effects of mindfulness-based intervention on glycemic control and psychological outcomes in people with diabetes: A systematic review and meta-analysis.

Ni YX, et al. · 2021

AIMS/INTRODUCTION: Psychological therapies have showed benefits for both glycemic control and psychological outcomes in people with diabetes. However, the effects of mindfulness-based intervention (MB…

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial.

Rosenstock J, et al. · 2021

BACKGROUND: Despite advancements in care, many people with type 2 diabetes do not meet treatment goals; thus, development of new therapies is needed. We aimed to assess efficacy, safety, and tolerabil…

Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data.

Goldenberg JZ, et al. · 2021

OBJECTIVE: To determine the efficacy and safety of low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) for people with type 2 diabetes. DESIGN: Systematic review and meta-analysis. D…

Efficacy of Dietary and Supplementation Interventions for Individuals with Type 2 Diabetes

Lewgood Jessica, Oliveira Barbara, Korzepa Marie, Forbes Scott C., Little Jonathan P., Breen Leigh, Bailie Robert, Candow Darren G. · 2021

The prevalence of Type 2 diabetes (T2D) is increasing, which creates a large economic burden. Diet is a critical factor in the treatment and management of T2D; however, there are a large number of die…

European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis.

Muscogiuri G, et al. · 2021

BACKGROUND: The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content…

Evidence Update on the Relationship between Diet and the Most Common Cancers from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: A Systematic Review.

Ubago-Guisado E, et al. · 2021

The European Prospective Investigation into Cancer and Nutrition (EPIC) is a multicentre prospective study conducted in 23 centres in 10 European countries. Here we review the findings from EPIC on th…

From Jekyll to Hyde: The Yeast-Hyphal Transition of Candida albicans.

Chow EWL, et al. · 2021

Candida albicans is a major fungal pathogen of humans, accounting for 15% of nosocomial infections with an estimated attributable mortality of 47%. C. albicans is usually a benign member of the human …

Glycemic index values of traditional Kenyan foods: the missing link in the effectiveness of dietary approach in the prevention and management of diabetes mellitus in Kenya

Ebere Rebecca, Imungi Jasper, Kimani Violet · 2021

Glycemic index (GI) measures postprandial blood sugar after consumption of carbohydrate-rich foodstuff. Kenya is yet to fully embrace this concept in prevention and management of diabetes mellitus. To…

Gut Microbiota and Complications of Type-2 Diabetes

Iatcu Camelia Oana, Steen Aimee, Covasa Mihai · 2021

The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. Uncontrolled diabetes ca…

Gut-microbiota-targeted diets modulate human immune status.

Wastyk HC, et al. · 2021

Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence t…

How should rheumatologists manage glucocorticoid-induced hyperglycemia?

Nakamura H, et al. · 2021

Glucocorticoid-induced hyperglycemia (GIH) is an important complication to be managed by rheumatologists as it can affect morbidity and mortality of patients. Before administration of glucocorticoids,…

Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise

Joseph Anu, Parvathy S., Varma Koyikkal Karthikeya · 2021

Insulin resistance is a state of impaired responsiveness to insulin action. This condition not only results in deficient glucose uptake but increases the risk for cardiovascular diseases (CVD), stroke…

Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses.

Nanayakkara N, et al. · 2021

AIMS/HYPOTHESIS: Few studies examine the association between age at diagnosis and subsequent complications from type 2 diabetes. This paper aims to summarise the risk of mortality, macrovascular compl…

Impact of color-coded and warning nutrition labelling schemes: A systematic review and network meta-analysis.

Song J, et al. · 2021

BACKGROUND: Suboptimal diets are a leading risk factor for death and disability. Nutrition labelling is a potential method to encourage consumers to improve dietary behaviour. This systematic review a…

Influence of sugar label formats on consumer understanding and amount of sugar in food choices: a systematic review and meta-analyses.

Scapin T, et al. · 2021

CONTEXT: Reducing population intakes of sugar has become a focus of many national and international public health policies. Packaged foods and beverages are key contributors to sugar intakes, and food…

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.

White PJ, et al. · 2021

BACKGROUND: A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine levels has been recognized in huma…

Insulin strategies for dietary fat and protein in type 1 diabetes: A systematic review.

Smith TA, et al. · 2021

AIM: To identify and report the efficacy of insulin strategies used to manage glycaemia following fat and/or fat and protein meals in type 1 diabetes. METHODS: A systematic literature search of medica…

International tables of glycemic index and glycemic load values 2021: a systematic review.

Atkinson FS, et al. · 2021

BACKGROUND: Reliable tables of glycemic indexes (GIs) and glycemic loads (GLs) are critical to research examining the relationship between glycemic qualities of carbohydrate in foods, diets, and healt…

Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children

Torun Anna, Hupalowska Anna, Trzonkowski Piotr, Kierkus Jaroslaw, Pyrzynska Beata · 2021

The incidence and prevalence rate of chronic inflammatory disorders is on the rise in the pediatric population. Recent research indicates the crucial role of interactions between the altered intestina…

Is Glycated Hemoglobin A1c Level Associated with Adverse Pregnancy Outcomes of Women Affected by Pre-Gestational Diabetes?

Xodo Serena, Londero Ambrogio Pietro, D’Agostin Martina, Novak Alice, Galasso Silvia, Pittini Carla, Baccarini Giovanni, Grimaldi Franco et al. · 2021

Background and Objectives : This observational study aims to determine the correlation between glycemic control with the HbA1c value and adverse obstetric outcome in women affected by pre-gestational …

Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies.

Li W, et al. · 2021

OBJECTIVES: Epidemiological studies have explored the relationship between work-related stress and the risk of type 2 diabetes mellitus (T2DM), but it remains unclear on whether work-related stress co…

Lemon juice, but not tea, reduces the glycemic response to bread in healthy volunteers: a randomized crossover trial.

Freitas D, et al. · 2021

PURPOSE: The inhibition of enzymes that hydrolyze starch during digestion could constitute an opportunity to slow down the release, and ultimately the uptake, of starch-derived glucose. Simple dietary…

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion.

Oberhauser L, et al. · 2021

Over the last decades, lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell fu…

Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes.

Gentile S, et al. · 2021

BACKGROUND: The number of older adults with insulin-treated diabetes mellitus (DM) is steadily increasing worldwide. Errors in the insulin injection technique can lead to skin lipohypertrophy (LH), wh…

Long-Term Complications in Youth-Onset Type 2 Diabetes.

Bjornstad P, et al. · 2021

BACKGROUND: The prevalence of type 2 diabetes in youth is increasing, but little is known regarding the occurrence of related complications as these youths transition to adulthood. METHODS: We previou…

Low-Calorie Sweeteners with Carbohydrate Do Not Impair Insulin Sensitivity in Humans: Re-analysis Highlighting the Importance of the Comparator.

Khan TA, et al. · 2021

The lack of appropriate comparator can lead to incorrect interpretation of results regarding low-calorie sweeteners. The result of a re-analysis of the study by Dalenberg et al. shows that the impairm…

Low-carbohydrate dietary pattern on glycemic outcomes trial (ADEPT) among individuals with elevated hemoglobin A1c: study protocol for a randomized controlled trial

Dorans Kirsten S., Bazzano Lydia A., Qi Lu, He Hua, Appel Lawrence J., Samet Jonathan M., Chen Jing, Mills Katherine T. et al. · 2021

Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality globally. Strong evidence supports the importance of diet and other lifestyle factors in preventing T2DM. Among individuals …

Maternal and neonatal outcomes after energy-restricted diet for women with gestational diabetes mellitus

Feng Yaofang, Zhao Zengcai, Fu Dayin, Gao Wen, Zhang Fei · 2021

Supplemental Digital Content is available in the text Gestational diabetes mellitus (GDM) affects 1% to 14% of pregnant women annually worldwide and is one of the most common pregnancy complications. …

Measurement Properties of Patient-Reported Outcome Measures for Diabetes: Systematic Review.

Wee PJL, et al. · 2021

BACKGROUND: The management of diabetes is complex. There is growing recognition of the use of patient-reported outcome measures (PROMs) as a standardized method of obtaining an outlook on patients' fu…

Mediterranean Diet and Type 2 Diabetes Mellitus: A Perpetual Inspiration for the Scientific World. A Review

Milenkovic Tatjana, Bozhinovska Nadica, Macut Djuro, Bjekic-Macut Jelica, Rahelic Dario, Velija Asimi Zelija, Burekovic Azra · 2021

For the past 80 years, the effect of the Mediterranean diet on overall health has been a constant topic of interest among medical and scientific researchers. Parallel with the persistent global rise o…

Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial.

Mingrone G, et al. · 2021

BACKGROUND: No data from randomised controlled trials of metabolic surgery for diabetes are available beyond 5 years of follow-up. We aimed to assess 10-year follow-up after surgery compared with medi…

Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.

Todd JN, et al. · 2021

OBJECTIVE: Maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 or type 2 diabetes. Correct diagnosis may result in a change in clinical treatment and impacts prediction of…

Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion.

Lu VB, et al. · 2021

The gastrointestinal tract can assess the nutrient composition of ingested food. The nutrient-sensing mechanisms in specialised epithelial cells lining the gastrointestinal tract, the enteroendocrine …

Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges

Petroni Maria Letizia, Brodosi Lucia, Marchignoli Francesca, Sasdelli Anna Simona, Caraceni Paolo, Marchesini Giulio, Ravaioli Federico · 2021

Unhealthy behaviours, including diet and physical activity, coupled with genetic predisposition, drive type 2 diabetes (T2D) occurrence and severity; the present review aims to summarise the most rece…

Obesity in Pregnancy: ACOG Practice Bulletin, Number 230.

· 2021

Obstetrician-gynecologists are the leading experts in the health care of women, and obesity is the most common medical condition in women of reproductive age. Obesity in women is such a common conditi…

Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.

Veronese N, et al. · 2021

There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to…

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

Vancells Lujan Pau, Viñas Esmel Esther, Sacanella Meseguer Emilio · 2021

NAFLD is the world’s most common chronic liver disease, and its increasing prevalence parallels the global rise in diabetes and obesity. It is characterised by fat accumulation in the liver evolving t…

Paleolithic Diet—Effect on the Health Status and Performance of Athletes?

Frączek Barbara, Pięta Aleksandra, Burda Adrian, Mazur-Kurach Paulina, Tyrała Florentyna · 2021

The aim of this meta-analysis was to review the impact of a Paleolithic diet (PD) on selected health indicators (body composition, lipid profile, blood pressure, and carbohydrate metabolism) in the sh…

Patient Work and Treatment Burden in Type 2 Diabetes: A Mixed-Methods Study.

Spencer-Bonilla G, et al. · 2021

OBJECTIVE: To use quantitative and qualitative methods to characterize the work patients with type 2 diabetes mellitus (T2DM) enact and explore the interactions between illness, treatment, and life. P…

Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations

Jardine Meghan A, Kahleova Hana, Levin Susan M, Ali Zeeshan, Trapp Caroline B, Barnard Neal D · 2021

A plant-based eating pattern is associated with a reduced risk of developing type 2 diabetes and is highly effective in its treatment. Diets that emphasize whole grains, vegetables, fruits, and legume…

Postintervention Effects of Varying Treatment Arms on Glycemic Failure and β-Cell Function in the TODAY Trial.

· 2021

OBJECTIVE: The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial demonstrated that glycemic failure rates were significantly lower in youth randomized to metformin plus rosi…

Potential diabetes overtreatment and risk of adverse events among older adults in Ontario: a population-based study.

Lega IC, et al. · 2021

AIMS/HYPOTHESIS: More than 25% of older adults (age ≥75 years) have diabetes and may be at risk of adverse events related to treatment. The aim of this study was to assess the prevalence of intensive …

Predisposing factors for the development of diabetic ketoacidosis with lower than anticipated glucose levels in type 2 diabetes patients on SGLT2-inhibitors: a review.

Bamgboye AO, et al. · 2021

PURPOSE: SGLT2-inhibitors (SGLT-2i) have been linked to the risk of potential life-threatening diabetic ketoacidosis (DKA). The U.S. Food and Drug Administration and the European Medicines Agency issu…

Prevention and Treatment of Atrial Fibrillation via Risk Factor Modification.

O'Keefe EL, et al. · 2021

Atrial fibrillation (AF) is the most common clinically significant arrhythmia, and it increases stroke risk. A preventive approach to AF is needed because virtually all treatments such as cardioversio…

Processed and Unprocessed Red Meat Consumption and Risk for Type 2 Diabetes Mellitus: An Updated Meta-Analysis of Cohort Studies.

Zhang R, et al. · 2021

Type II diabetes mellitus (T2DM) is a metabolic disorder that occurs in the body because of decreased insulin activity and/or insulin secretion. The incidence of T2DM has rapidly increased over recent…

Risk factors for diabetic foot complications in type 2 diabetes-A systematic review.

Rossboth S, et al. · 2021

AIMS: With increasing numbers of patients with type 2 diabetes mellitus (T2DM) worldwide, the number of associated diabetic foot complications might also increase. This systematic review was performed…

Sleep interventions and glucose metabolism: systematic review and meta-analysis.

Kothari V, et al. · 2021

OBJECTIVE: Sleep disturbances (insufficient or poor sleep quality) have been linked to abnormal glucose metabolism. This systematic review and meta-analysis aimed to explore the effects of behavioral …

Standardizing the haemoglobin glycation index

Hempe James M., Yang Shengping, Liu Shuqian, Hsia Daniel S. · 2021

A high haemoglobin glycation index (HGI) is associated with greater risk for hypoglycaemia and chronic vascular disease. Standardizing how the HGI is calculated would normalize results between researc…

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.

Jenkins DJA, et al. · 2021

This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled …

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals.

Sims EK, et al. · 2021

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic function and immune cells among participants in a previously reported randomized controlled trial of nondiabetic …

The Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns.

Hemmer A, et al. · 2021

Energy metabolism is tightly linked with circadian rhythms, exposure to ambient light, sleep/wake, fasting/eating, and rest/activity cycles. External factors, such as shift work, lead to a disruption …

The Impact of Hypo- and Hyperglycemia on Cognition and Brain Development in Young Children with Type 1 Diabetes.

Nevo-Shenker M, et al. · 2021

Human and experimental animal data suggest both hyperglycemia and hypoglycemia can lead to altered brain structure and neurocognitive function in type 1 diabetes (T1D). Young children with T1D are pro…

The International Society of Renal Nutrition and Metabolism Commentary on the National Kidney Foundation and Academy of Nutrition and Dietetics KDOQI Clinical Practice Guideline for Nutrition in Chronic Kidney Disease.

Kistler BM, et al. · 2021

The Academy of Nutrition and Dietetics and the National Kidney Foundation collaborated to provide an update to the Clinical Practice Guidelines (CPG) for nutrition in chronic kidney disease (CKD). The…

The Low-Carbohydrate Diet: Short-Term Metabolic Efficacy Versus Longer-Term Limitations

Barber Thomas M., Hanson Petra, Kabisch Stefan, Pfeiffer Andreas F. H., Weickert Martin O. · 2021

Background: Diets have been a central component of lifestyle modification for decades. The Low-Carbohydrate Diet (LCD), originally conceived as a treatment strategy for intractable epilepsy (due to it…

The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children

Bauer Witold, Gyenesei Attila, Krętowski Adam · 2021

Type 1 Diabetes (T1D) results from autoimmune destruction of insulin producing pancreatic ß-cells. This disease, with a peak incidence in childhood, causes the lifelong need for insulin injections and…

The Relationship Between Executive Functioning, Type 1 Diabetes Self-Management Behaviors, and Glycemic Control in Adolescents and Young Adults.

Ding K, et al. · 2021

PURPOSE OF REVIEW: Understanding barriers to self-management behaviors and glycemic stability may inform specific needs for behavior change in adolescents and young adults with type 1 diabetes (T1D). …

The Relationship between Modern Fad Diets and Kidney Stone Disease: A Systematic Review of Literature.

Barghouthy Y, et al. · 2021

OBJECTIVES: Kidney stone disease (KSD) has a strong association with diet metabolic syndrome. This review aims at exploring the lithogenic risk posed by the current most popular diets. Our approach wa…

The aetiology and molecular landscape of insulin resistance.

James DE, et al. · 2021

Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in tissues - prominently in muscle, fat and liver - is one of the earliest manifestations of a constellation o…

The effectiveness of peer support on self-efficacy and self-management in people with type 2 diabetes: A meta-analysis.

Liang D, et al. · 2021

OBJECTIVES: This study aims to investigate the effectiveness of peer support on self-efficacy and self-management in people with type 2 diabetes. METHODS: Eight databases were utilized for selecting e…

The experiences of pregnant women with gestational diabetes mellitus: a systematic review of qualitative evidence.

He J, et al. · 2021

Gestational diabetes mellitus (GDM) can have serious adverse effects on pregnant women and their fetuses. The purpose of this systematic review is to explore responses from women diagnosed with GDM an…

The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Holt Richard I. G., DeVries J. Hans, Hess-Fischl Amy, Hirsch Irl B., Kirkman M. Sue, Klupa Tomasz, Ludwig Barbara, Nørgaard Kirsten et al. · 2021

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in …

The prevalence and evidence-based management of needle fear in adults with chronic disease: A scoping review.

Duncanson E, et al. · 2021

BACKGROUND: Little is known about the prevalence and best management of needle fear in adults with chronic disease, who may experience frequent and long-term exposure to needles for lifesaving therapi…

The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease

Jennison Erica, Byrne Christopher D. · 2021

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. …

The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods.

Carlton J, et al. · 2021

AIMS/HYPOTHESIS: It is generally accepted that hypoglycaemia can negatively impact the quality of life (QoL) of people living with diabetes. However, the suitability of patient-reported outcome measur…

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.

Frías JP, et al. · 2021

BACKGROUND: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that is under development for the treatment of type 2 diabetes. The …

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017.

Lawrence JM, et al. · 2021

IMPORTANCE: Changes in the prevalence of youth-onset diabetes have previously been observed. OBJECTIVE: To estimate changes in prevalence of type 1 and type 2 diabetes in youths in the US from 2001 to…

Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.

Pearson-Stuttard J, et al. · 2021

BACKGROUND: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of developing several common cancers, but it is unclear whether this association is causal. We aimed to summarize…

Understanding the gut microbiota and sarcopenia: a systematic review.

Liu C, et al. · 2021

BACKGROUND: Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut-muscle axis has been raised, the casual relationship is still unclear. This systemati…

Unraveling the concepts of distress, burnout, and depression in type 1 diabetes: A scoping review.

Kiriella DA, et al. · 2021

BACKGROUND: Psychological complications are frequent in type 1 diabetes (T1D) but they might be difficult to distinguish one from the other in clinical practice. Our objective was to study the disting…

Watermelon and L-Citrulline in Cardio-Metabolic Health: Review of the Evidence 2000-2020.

Burton-Freeman B, et al. · 2021

PURPOSE OF REVIEW: Watermelon (Citrullus lanatus) distinctively contains L-citrulline and L-arginine, precursors of nitric oxide (NO), along with polyphenols and carotenoids suggesting a role in cardi…

Yogurt, cultured fermented milk, and health: a systematic review.

Savaiano DA, et al. · 2021

Consumption of yogurt and other fermented products is associated with improved health outcomes. Although dairy consumption is included in most dietary guidelines, there have been few specific recommen…

β-Casomorphin: A complete health perspective.

Thiruvengadam M, et al. · 2021

β-Casomorphin-7 (BCM-7) is a heptapeptide dietary molecule derived from the digestion of the β-casein of dairy and dairy products. In this review, we have covered the extensive details about BCM and i…

A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes.

Kubota S, et al. · 2020

While adjustment of total energy and nutritional balance is critically important, meal sequence, a relatively simple method of correcting postprandial hyperglycemia, is becoming established as a pract…

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement.

Eslam M, et al. · 2020

The exclusion of other chronic liver diseases including "excess" alcohol intake has until now been necessary to establish a diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD). H…

A systematic review on the safety of Ramadan fasting in high-risk patients with Diabetes.

Rashid F, et al. · 2020

INTRODUCTION: Fasting the holy month of Ramadan is passionately practiced by all Muslim population around the world. Patients with diabetes are generally considered to have a higher risk of fasting. T…

Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance

Duft Renata G., Castro Alex, Bonfante Ivan L. P., Lopes Wendell A., da Silva Larissa R., Chacon-Mikahil Mara P. T., Leite Neiva, Cavaglieri Cláudia R. · 2020

Exercise training and a healthy diet are the main non-pharmacological strategies for treating chronic conditions, such as obesity and insulin resistance (IR), in adolescents. However, the isolated met…

Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine

Xu Xizhan, Gao Zezheng, Yang Fuquan, Yang Yingying, Chen Liang, Han Lin, Zhao Na, Xu Jiayue et al. · 2020

Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus . However, the main l…

Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis

Qin Xin, Jiang Ming, Zhao Yan, Gong Jing, Su Hao, Yuan Fen, Fang Ke, Yuan Xiaoyi et al. · 2020

Disordered lipid metabolism and disturbed mitochondrial bioenergetics play pivotal roles in the initiation and development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used in Chin…

British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery-2020 update.

O'Kane M, et al. · 2020

Bariatric surgery is recognized as the most clinically and cost-effective treatment for people with severe and complex obesity. Many people presenting for surgery have pre-existing low vitamin and min…

Chrononutrition in the management of diabetes.

Henry CJ, et al. · 2020

Circadian rhythms are 24-h cycles regulated by endogeneous molecular oscillators called the circadian clock. The effects of diet on circadian rhythmicity clearly involves a relationship between factor…

Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.

Tsapas A, et al. · 2020

BACKGROUND: Several pharmacologic options for type 2 diabetes are available. PURPOSE: To compare benefits and harms of glucose-lowering drugs in adults with type 2 diabetes. DATA SOURCES: Several data…

Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.

Pillinger T, et al. · 2020

BACKGROUND: Antipsychotic treatment is associated with metabolic disturbance. However, the degree to which metabolic alterations occur in treatment with different antipsychotics is unclear. Predictors…

Consumption of a Beverage Containing Aspartame and Acesulfame K for Two Weeks Does Not Adversely Influence Glucose Metabolism in Adult Males and Females: A Randomized Crossover Study.

Kim Y, et al. · 2020

There is an association between the consumption of artificial sweeteners and Type 2 diabetes in cohort studies, but intervention studies do not show a clear elevation of blood glucose after the use of…

Dapagliflozin in Patients with Chronic Kidney Disease.

Heerspink HJL, et al. · 2020

BACKGROUND: Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without ty…

Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy

Preguiça Inês, Alves André, Nunes Sara, Gomes Pedro, Fernandes Rosa, Viana Sofia D., Reis Flávio · 2020

Unhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular compl…

Dietary Glycemic Index and Glycemic Load Are Not Associated with the Metabolic Syndrome in Lebanese Healthy Adults: A Cross-Sectional Study

Borgi Cecile, Taktouk Mandy, Nasrallah Mona, Isma’eel Hussain, Tamim Hani, Nasreddine Lara · 2020

High dietary glycemic index (GI) and glycemic load (GL) were suggested to increase the risk of metabolic syndrome (MetS). This study aims to estimate dietary GI and GL in a sample of healthy Lebanese …

Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses.

Reynolds AN, et al. · 2020

BACKGROUND: Fibre is promoted as part of a healthy dietary pattern and in diabetes management. We have considered the role of high-fibre diets on mortality and increasing fibre intake on glycaemic con…

Does Treatment for Depression With Collaborative Care Improve the Glycemic Levels in Diabetic Patients with Depression? A Systematic Review.

Diaz Bustamante L, et al. · 2020

Diabetes is a chronic disease with a high prevalence in the United States. If not treated adequately, it can have serious complications. Furthermore, when depression affects concomitantly, adherence t…

Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data

Gabriel Rafael, Boukichou Abdelkader Nisa, Acosta Tania, Gilis-Januszewska Aleksandra, Gómez-Huelgas Ricardo, Makrilakis Konstantinos, Kamenov Zdravko, Paulweber Bernhard et al. · 2020

To assess the effects of early management of hyperglycaemia with antidiabetic drugs plus lifestyle intervention compared with lifestyle alone, on microvascular function in adults with pre-diabetes. Tr…

Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.

Laffel LM, et al. · 2020

IMPORTANCE: Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals with type 1 diabetes across the lifespan. Although continuous glucose monitoring (CGM…

Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes.

Bjornstad P, et al. · 2020

OBJECTIVE: To compare diabetic kidney disease (DKD) rates over 5 years of follow-up in two cohorts of severely obese adolescents with type 2 diabetes (T2D) undergoing medical or surgical treatment for…

Effect of sucralose and aspartame on glucose metabolism and gut hormones.

Ahmad SY, et al. · 2020

Non-nutritive sweeteners are thought to be useful replacements for caloric sweeteners in sweet food and beverages, since the reduction in energy and carbohydrate intake may lead to health benefits ste…

Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis

Yuan Xiaojie, Wang Jiping, Yang Shuo, Gao Mei, Cao Lingxia, Li Xumei, Hong Dongxu, Tian Suyan et al. · 2020

At present, the beneficial effect of the ketogenic diet (KD) on weight loss in obese patients is generally recognized. However, a systematic research on the role of KD in the improvement of glycemic a…

Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus

Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi · 2020

Exercise therapy is used for glycemic control in type 2 diabetes mellitus (T2DM). We evaluated the effects of intensive health guidance using the Internet of things (IoT) among Japanese company worker…

Effectiveness of real-time continuous glucose monitoring to improve glycaemic control and pregnancy outcome in patients with gestational diabetes mellitus: a study protocol for a randomised controlled trial

Huhn Evelyn Annegret, Linder Tina, Eppel Daniel, Weißhaupt Karen, Klapp Christine, Schellong Karen, Henrich Wolfgang, Yerlikaya-Schatten Gülen et al. · 2020

Real-time continuous glucose monitoring (rt-CGM) informs users about current interstitial glucose levels and allows early detection of glycaemic excursions and timely adaptation by behavioural change …

Effects of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers in Patients with Type 2 Diabetes Mellitus: a Randomized Clinical Trial

Talab Aria Tavakoli, Abdollahzad Hadi, Nachvak Seyyed Mustafa, Pasdar Yahya, Eghtesadi Shahryar, Izadi Azimeh, Aghdashi Mir Amir, Mohammad Hossseini Azar Mohammad Reza et al. · 2020

Type 2 diabetes mellitus (T2DM) is a serious public health problem accompanies with several complications. This study was conducted to evaluate the effects of chromium picolinate (CrPic) supplementati…

Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Asbaghi O, et al. · 2020

BACKGROUND: We aimed to investigate the effect of chromium supplementation on glycemic control indices in patients with type 2 diabetes (T2DM). METHODS: Randomized controlled trials examining the effe…

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus.

Wu CZ, et al. · 2020

BACKGROUND: To systematically review the epidemiologic relationship between periodontitis and type 2 diabetes mellitus (T2DM). METHODS: Four electronic databases were searched up until December 2018. …

Establishment and Validation of a Risk Prediction Model for Early Diabetic Kidney Disease Based on a Systematic Review and Meta-Analysis of 20 Cohorts.

Jiang W, et al. · 2020

BACKGROUND: Identifying patients at high risk of diabetic kidney disease (DKD) helps improve clinical outcome. PURPOSE: To establish a model for predicting DKD. DATA SOURCES: The derivation cohort was…

Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms

Zhou He, Sun Lin, Zhang Siwen, Zhao Xue, Gang Xiaokun, Wang Guixia · 2020

Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to …

Exercise Affects Blood Glucose Levels and Tissue Chromium Distribution in High-Fat Diet-Fed C57BL6 Mice

Chang Geng-Ruei, Hou Po-Hsun, Chen Wen-Kai, Lin Chien-Teng, Tsai Hsiao-Pei, Mao Frank Chiahung · 2020

Obesity is commonly associated with hyperglycemia and type 2 diabetes and negatively affects chromium accumulation in tissues. Exercise prevents and controls obesity and type 2 diabetes. However, litt…

Exercise-Induced Improvements in Insulin Sensitivity Are Not Attenuated by a Family History of Type 2 Diabetes

Amador Manuel, Meza Cesar A., McAinch Andrew J., King George A., Covington Jeffrey D., Bajpeyi Sudip · 2020

Introduction: A family history of type 2 diabetes (FH+) is a major risk factor for the development of insulin resistance and type 2 diabetes. However, it remains unknown whether exercise-induced impro…

Exercise-Induced Improvements to Whole Body Glucose Metabolism in Type 2 Diabetes: The Essential Role of the Liver

Warner Shana O., Yao Michael V., Cason Rebecca L., Winnick Jason J. · 2020

Type 2 diabetes (T2D) is a metabolic disease characterized by obesity, insulin resistance, and the dysfunction of several key glucoregulatory organs. Among these organs, impaired liver function is rec…

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.

Carter CS, et al. · 2020

Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limit…

Food Insecurity and Insulin Use in Hyperglycemic Patients Presenting to the Emergency Department.

Nhoung HK, et al. · 2020

INTRODUCTION: The prevalence of food insecurity (FI) and insulin rationing among patients with diabetes who present to the emergency department (ED) is unclear. We examined the prevalence of food inse…

Gene polymorphisms of Patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin, leptin in diabetic obese patients

Aly Omnia, Zaki Hanan Hassan, Herzalla Mohamed R., Fathy Ahmed, Raafat Nermin, Hafez Mohamed M., Hamdy Nadia M, Hamdy Nadia M et al. · 2020

Obesity leads a crucial importance in metabolic disorders, as well as type 2 diabetes mellitus. Our present study was designed to assess the potential role of irisin, adiponectin, leptin and gene poly…

Glycemic Index (GI) or Glycemic Load (GL) and Dietary Interventions for Optimizing Postprandial Hyperglycemia in Patients with T2 Diabetes: A Review

Vlachos Dionysios, Malisova Sofia, Lindberg Fedon A., Karaniki Georgia · 2020

The increasing prevalence of type 2 diabetes (T2D) worldwide calls for effective approaches to its management. Strategies for diabetes have generally focused on optimizing overall glycemic control as …

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention.

Liu Y, et al. · 2020

Exercise is an effective strategy for diabetes management but is limited by the phenomenon of exercise resistance (i.e., the lack of or the adverse response to exercise on metabolic health). Here, in …

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study).

Zhang Y, et al. · 2020

Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabol…

High-protein meals require 30% additional insulin to prevent delayed postprandial hyperglycaemia.

Paterson MA, et al. · 2020

AIM: To determine the amount of additional insulin required for a high-protein meal to prevent postprandial hyperglycaemia in individuals with type 1 diabetes using insulin pump therapy. METHODS: In t…

Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

Choi Yeo Jin, Jeon Sang-Min, Shin Sooyoung · 2020

The aim of this meta-analysis was to explore the efficacy of a ketogenic diet in metabolic control in patients with overweight or obesity and with or without type 2 diabetes. Embase, PubMed, and Cochr…

Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes.

Mason IC, et al. · 2020

The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including gluco…

Impact of obesity on the increasing incidence of type 1 diabetes.

Buzzetti R, et al. · 2020

Published estimates of the incidence of type 1 diabetes (T1D) in children in the last decade varies between 2% and 4% per annum. If this trend continued, the disease incidence would double in the next…

In-Person and Technology-Mediated Peer Support in Diabetes Care: A Systematic Review of Reviews and Gap Analysis.

Litchman ML, et al. · 2020

PURPOSE: The purpose of this study is to report a systematic review of reviews of evidence and gaps focused on in-person and technology-mediated diabetes peer support and its impact on clinical, behav…

Intermittent fasting and weight loss: Systematic review.

Welton S, et al. · 2020

OBJECTIVE: To examine the evidence for intermittent fasting (IF), an alternative to calorie-restricted diets, in treating obesity, an important health concern in Canada with few effective office-based…

Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta-analysis.

Wilson CA, et al. · 2020

AIM: Gestational diabetes (GDM) and mental disorder are common perinatal morbidities and are associated with adverse maternal and child outcomes. While there is a relationship between type 2 diabetes …

Low-Carbohydrate Diets in the Management of Obesity and Type 2 Diabetes: A Review from Clinicians Using the Approach in Practice

Kelly Tara, Unwin David, Finucane Francis · 2020

Low-carbohydrate diets are increasingly used to help patients with obesity and type 2 diabetes. We sought to provide an overview of the evidence for this treatment approach, considering the epidemiolo…

Low-carbohydrate interventions for adolescent obesity: Nutritional adequacy and guidance for clinical practice.

Jebeile H, et al. · 2020

Low-carbohydrate dietary patterns are re-emerging as a popular method of weight reduction. However, their nutritional adequacy to meet the needs of growing adolescents should be considered. This study…

Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.

Buzzetti R, et al. · 2020

A substantial proportion of patients with adult-onset diabetes share features of both type 1 diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically resemble T2D patients…

Medication-induced hyperglycemia: pediatric perspective.

Tosur M, et al. · 2020

Medication-induced hyperglycemia is a frequently encountered clinical problem in children. The intent of this review of medications that cause hyperglycemia and their mechanisms of action is to help g…

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

Ghosh TS, et al. · 2020

OBJECTIVE: Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterati…

New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress

Ferro Domenico, Baratta Francesco, Pastori Daniele, Cocomello Nicholas, Colantoni Alessandra, Angelico Francesco, Del Ben Maria · 2020

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The intricate NAFLD pathogenesis is summarized by the multiple-hits hypothesis, which combines all the env…

Novel Insights and Mechanisms of Lipotoxicity-Driven Insulin Resistance.

Lair B, et al. · 2020

A large number of studies reported an association between elevated circulating and tissue lipid content and metabolic disorders in obesity, type 2 diabetes (T2D) and aging. This state of uncontrolled …

Nutrients, Genetic Factors, and Their Interaction in Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease

Lombardi Rosa, Iuculano Federica, Pallini Giada, Fargion Silvia, Fracanzani Anna Ludovica · 2020

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and expose patients to increased risk of hepatic and cardiovascular (CV) morbidity and mortality…

Origins of the Crisis in Insulin Affordability and Practical Advice for Clinicians on Using Human Insulin.

Luo J, et al. · 2020

PURPOSE OF REVIEW: High insulin prices and cost-related insulin underuse are increasingly common and vexing problems for healthcare providers. This review highlights several factors that contribute to…

Parental Stress, Anxiety and Depression Symptoms Associated with Self-Efficacy in Paediatric Type 1 Diabetes: A Literature Review.

Bassi G, et al. · 2020

Background: Parents play a significant role in the management and monitoring of their children's Type 1 diabetes mellitus (T1DM), being considered a family disease. The current review intends to inves…

Pathophysiology of Type 2 Diabetes in Children and Adolescents.

Valaiyapathi B, et al. · 2020

BACKGROUND: The prevalence of type 2 diabetes (DM) in children is disturbingly increasing in parallel with the increasing childhood obesity. Better knowledge regarding the pathophysiology of type 2 DM…

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

Belwal Tarun, Bisht Aarti, Devkota Hari Prasad, Ullah Hammad, Khan Haroon, Pandey Aseesh, Bhatt Indra Dutt, Echeverría Javier · 2020

The incidences of diabetic mellitus and other metabolic diseases such as hypertension and hyperlipidemia are increasing worldwide; however, the current treatment is not able to control the rapidly inc…

Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes

Feskens Edith, Brennan Lorraine, Dussort Pierre, Flourakis Matthieu, Lindner Lena M E, Mela David, Rabbani Naila, Rathmann Wolfgang et al. · 2020

There is considerable interest in dietary and other approaches to maintaining blood glucose concentrations within the normal range and minimizing exposure to postprandial hyperglycemic excursions. The…

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production.

Deehan EC, et al. · 2020

Dietary fibers (DFs) impact the gut microbiome in ways often considered beneficial. However, it is unknown if precise and predictable manipulations of the gut microbiota, and especially its metabolic …

Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study.

Flatt AJS, et al. · 2020

OBJECTIVE: The HypoCOMPaSS study was designed to test the hypothesis that successful avoidance of biochemical hypoglycemia without compromising overall glycemic control would restore sufficient hypogl…

Preventive Role of Diet Interventions and Dietary Factors in Type 2 Diabetes Mellitus: An Umbrella Review

Toi Phung Lam, Anothaisintawee Thunyarat, Chaikledkaew Usa, Briones Jamaica Roanne, Reutrakul Sirimon, Thakkinstian Ammarin · 2020

Background: Although the body of evidence indicates clear benefits of dietary modifications for prevention of type-2 diabetes mellitus (T2DM), it may be difficult for healthcare providers to recommend…

Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials

Kocsis Tícia, Molnár Bálint, Németh Dávid, Hegyi Péter, Szakács Zsolt, Bálint Alexandra, Garami András, Soós Alexandra et al. · 2020

Probiotics have been reported to have a positive impact on the metabolic control of patients with type 2 diabetes. We aimed to systematically evaluate the effects of probiotics on cardiometabolic para…

Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.

Winkley K, et al. · 2020

BACKGROUND: For people with diabetes mellitus to achieve optimal glycaemic control, motivation to perform self-management is important. The research team wanted to determine whether or not psychologic…

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance.

Dubey P, et al. · 2020

Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in…

Role of gut microbiota in type 2 diabetes pathophysiology.

Gurung M, et al. · 2020

A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular tax…

Self-determination theory and motivational interviewing interventions for type 2 diabetes prevention and treatment: A systematic review.

Phillips AS, et al. · 2020

Treatment of those with obesity, prediabetes, and type 2 diabetes often yields initial health improvements, but gains erode over time. A systematic search of self-determination theory and motivational…

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity

ter Horst Rob, van den Munckhof Inge C.L., Schraa Kiki, Aguirre-Gamboa Raul, Jaeger Martin, Smeekens Sanne P., Brand Tessa, Lemmers Heidi et al. · 2020

Supplemental Digital Content is available in the text. Metabolic dysregulation and inflammation are important consequences of obesity and impact susceptibility to cardiovascular disease. Anti-inflamma…

Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.

Dalenberg JR, et al. · 2020

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relat…

Skipping breakfast is associated with glycemic variability in patients with type 2 diabetes.

Hashimoto Y, et al. · 2020

OBJECTIVES: The association between skipping breakfast and glycemic parameters, including glycemic variability, in patients with type 2 diabetes is not well understood. Therefore, the aim of this stud…

South Indian Cuisine with Low Glycemic Index Ingredients Reduces Cardiovascular Risk Factors in Subjects with Type 2 Diabetes

Pavithran Nivedita, Kumar Harish, Menon Arun Somasekharan, Pillai Gopala Krishna, Sundaram Karimassery Ramaiyer, Ojo Omorogieva · 2020

Background : Inflammation is considered as a predictor of cardiovascular diseases in type 2 diabetes mellitus. No previous studies have investigated the effect of low glycemic index (LGI) recipes of S…

Sucralose Consumption over 2 Weeks in Healthy Subjects Does Not Modify Fasting Plasma Concentrations of Appetite-Regulating Hormones: A Randomized Clinical Trial.

Romo-Romo A, et al. · 2020

BACKGROUND: The effect of nonnutritive sweeteners on appetite is controversial. Some studies have found changes in certain appetite control hormones with sucralose intake that may be through interacti…

Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies.

Qin P, et al. · 2020

Although consumption of sugar-sweetened beverages (SSBs) and artificially sweetened beverages (ASBs) has increasingly been linked with obesity, type 2 diabetes mellitus, hypertension, and all-cause mo…

Systematic review and meta-analysis of randomized controlled trials of psychological interventions to improve glycaemic control in children and adults with type 1 diabetes.

Winkley K, et al. · 2020

AIM: We conducted a systematic review aggregate and network meta-analysis of psychological interventions for people with type 1 diabetes to assess their effectiveness in improving glycaemic levels. ME…

The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance.

Oosterman JE, et al. · 2020

Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted …

The Effect of Metabolic Surgery on the Complications of Diabetes: What Are the Unanswered Questions?

Neff Karl J., Le Roux Carel W. · 2020

It is now established that metabolic surgery (also known as bariatric surgery or obesity surgery) is an effective treatment for type 2 diabetes. Data from several randomized controlled trials have sho…

The Effect of a Low GI Diet on Truncal Fat Mass and Glycated Hemoglobin in South Indians with Type 2 Diabetes—A Single Centre Randomized Prospective Study

Pavithran Nivedita, Kumar Harish, Menon Arun Somasekharan, Pillai Gopala Krishna, Sundaram Karimassery Ramaiyer, Ojo Omorogieva · 2020

Background: There has been no previous study that has investigated the effect of a low glycemic index (LGI) diet with local recipes of South Indian cuisine on the body fat composition using dual-energ…

The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial.

Ahmad SY, et al. · 2020

Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose an…

The Effects of a Low Calorie Ketogenic Diet on Glycaemic Control Variables in Hyperinsulinemic Overweight/Obese Females

Michalczyk Małgorzata Magdalena, Klonek Grzegorz, Maszczyk Adam, Zajac Adam · 2020

Diet is a factor which can influence both glycaemic variables and body mass. The aim of this study was to compare the influence of a 12-week, well-planned, low-calorie ketogenic diet (LCKD) on hypergl…

The Impact of Dietary Glycemic Index and Glycemic Load on Postprandial Lipid Kinetics, Dyslipidemia and Cardiovascular Risk

Lambadiari Vaia, Korakas Emmanouil, Tsimihodimos Vasilios · 2020

Many recent studies have acknowledged postprandial hypetriglyceridemia as a distinct risk factor for cardiovascular disease. This dysmetabolic state is the result of the hepatic overproduction of very…

The Inflammasome in Chronic Complications of Diabetes and Related Metabolic Disorders

Menini Stefano, Iacobini Carla, Vitale Martina, Pugliese Giuseppe · 2020

Diabetes mellitus (DM) ranks seventh as a cause of death worldwide. Chronic complications, including cardiovascular, renal, and eye disease, as well as DM-associated non-alcoholic fatty liver disease …

The Interactive Effect of High Doses of Chromium(III) and Different Iron(III) Levels on the Carbohydrate Status, Lipid Profile, and Selected Biochemical Parameters in Female Wistar Rats

Staniek Halina Zofia, Król Ewelina, Wójciak Rafał Wojciech · 2020

The aim of the study was to evaluate the main and interactive effects of chromium(III) propionate complex (Cr3) supplementation and different iron supply on the carbohydrate metabolism, lipid profile …

The ketogenic diet: Pros and cons.

O'Neill B, et al. · 2020

Diets have been at the center of animated debates for decades and many claims have been made in one direction or the other by supporters of opposite camps, often with limited evidence. At times emphas…

The role of psychological insulin resistance in diabetes self-care management.

Lim A, et al. · 2020

AIMS: The purpose of this study was to identify the role of psychological insulin resistance in the relationship between diabetes self-efficacy and diabetes self-care management in people with diabete…

Therapeutic use of intermittent fasting and ketogenic diet as an alternative treatment for type 2 diabetes in a normal weight woman: a 14-month case study

Lichtash Charlene, Fung Jason, Ostoich Katherine Connor, Ramos Megan · 2020

This case demonstrates the effective and sustainable use of intermittent fasting (IF) and ketogenic diet (KD) in a normal weight patient with type 2 diabetes, who did not attain glycaemic control with…

Twenty-five years of diabetes distress research.

Skinner TC, et al. · 2020

The term 'diabetes distress' first entered the psychosocial research vernacular in 1995, and refers to 'the negative emotional or affective experience resulting from the challenge of living with the d…

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

Roep Bart O., Thomaidou Sofia, van Tienhoven René, Zaldumbide Arnaud · 2020

Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that autoreactive T…

Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants of the NutriNet-Santé Prospective Cohort.

Srour B, et al. · 2020

IMPORTANCE: Ultraprocessed foods (UPF) are widespread in Western diets. Their consumption has been associated in recent prospective studies with increased risks of all-cause mortality and chronic dise…

Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany.

Ziegler AG, et al. · 2020

IMPORTANCE: Public health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and burden on a population level. OBJECTIVE: To determine the prevalence of presymptoma…

A mobile app identifies momentary psychosocial and contextual factors related to mealtime self-management in adolescents with type 1 diabetes.

Mulvaney SA, et al. · 2019

Effective diabetes problem solving requires identification of risk factors for inadequate mealtime self-management. Ecological momentary assessment was used to enhance identification of factors hypoth…

A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk.

Hinkle SN, et al. · 2019

BACKGROUND: Artificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk for cardiometabolic diseases; however, the health effects of ASBs remain contradi…

A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.

Higgins KA, et al. · 2019

BACKGROUND: Low-calorie sweeteners (LCSs) provide sweetness with little or no energy. However, each LCS's unique chemical structure has potential to elicit different sensory, physiological, and behavi…

A whey/guar "preload" improves postprandial glycaemia and glycated haemoglobin levels in type 2 diabetes: A 12-week, single-blind, randomized, placebo-controlled trial.

Watson LE, et al. · 2019

AIMS: To evaluate the effects of 12 weeks of treatment with a whey/guar preload on gastric emptying, postprandial glycaemia and glycated haemoglobin (HbA1c) levels in people with type 2 diabetes (T2DM…

Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics.

Sandberg J, et al. · 2019

PURPOSE: We previously showed that short-term intervention with barley kernel bread (BKB) improved glucose tolerance. However, glucose tolerance was not improved in a subset of individuals (non-respon…

Addressing diabetes distress in clinical care: a practical guide.

Fisher L, et al. · 2019

Addressing the emotional side of diabetes and its management has received considerable attention in recent years. At the centre of most of these efforts is the concept of 'diabetes distress', a generi…

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

Herold KC, et al. · 2019

BACKGROUND: Type 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival. Some interventions have delayed …

An Intensive Lifestyle Intervention to Treat Type 2 Diabetes in the Republic of the Marshall Islands: Protocol for a Randomized Controlled Trial

Davis Brenda C., Jamshed Humaira, Peterson Courtney M., Sabaté Joan, Harris Ralph D., Koratkar Rohit, Spence Jamie W., Kelly John H. · 2019

Background: The Republic of the Marshall Islands has the highest prevalence of type 2 diabetes (T2D) in the world, with the country's rapid rise of T2D attributed to its reliance on imported and refin…

Apple Preload Halved the Postprandial Glycaemic Response of Rice Meal on in Healthy Subjects.

Lu J, et al. · 2019

This study aimed to investigate the possible glycemic effect of apple preload on acute postprandial glycemic responses (GRs) of a following rice meal, comparing with its co-ingestion counterpart and a…

Association Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis.

Qian F, et al. · 2019

IMPORTANCE: Accumulating epidemiologic evidence has suggested favorable associations between plant-based dietary patterns and risk of type 2 diabetes, although there is a lack of a quantitative summar…

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk.

Andrén Aronsson C, et al. · 2019

IMPORTANCE: High gluten intake during childhood may confer risk of celiac disease. OBJECTIVES: To investigate if the amount of gluten intake is associated with celiac disease autoimmunity and celiac d…

Associations of foot ulceration with quality of life and psychosocial determinants among patients with diabetes; a case-control study.

Alosaimi FD, et al. · 2019

BACKGROUND: Patients with diabetic foot ulcers may have a lower quality of life. The objective was to compare the quality of life and its psychosocial determinants among patients with and without diab…

CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITION, METABOLIC, AND NONSURGICAL SUPPORT OF PATIENTS UNDERGOING BARIATRIC PROCEDURES - 2019 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY, THE OBESITY SOCIETY, AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY, OBESITY MEDICINE ASSOCIATION, AND AMERICAN SOCIETY OF ANESTHESIOLOGISTS - EXECUTIVE SUMMARY.

Mechanick JI, et al. · 2019

Objective: The development of these updated clinical practice guidelines (CPGs) was commissioned by the American Association of Clinical Endocrinologists (AACE), The Obesity Society, American Society …

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

Perkovic V, et al. · 2019

BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose co…

Carbohydrate Restriction in Type 1 Diabetes: A Realistic Therapy for Improved Glycaemic Control and Athletic Performance?

Scott Sam N., Anderson Lorraine, Morton James P., Wagenmakers Anton J. M., Riddell Michael C. · 2019

Around 80% of individuals with Type 1 diabetes (T1D) in the United States do not achieve glycaemic targets and the prevalence of comorbidities suggests that novel therapeutic strategies, including lif…

Carbohydrate quality and human health: a series of systematic reviews and meta-analyses.

Reynolds A, et al. · 2019

BACKGROUND: Previous systematic reviews and meta-analyses explaining the relationship between carbohydrate quality and health have usually examined a single marker and a limited number of clinical out…

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.

Kristensen SL, et al. · 2019

BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists differ in their structure and duration of action and have been studied in trials of varying sizes and with different patient populations, …

Circadian clocks and insulin resistance.

Stenvers DJ, et al. · 2019

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in t…

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.

Battelino T, et al. · 2019

Improvements in sensor accuracy, greater convenience and ease of use, and expanding reimbursement have led to growing adoption of continuous glucose monitoring (CGM). However, successful utilization o…

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

Wiviott SD, et al. · 2019

BACKGROUND: The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined. METHODS…

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.

McMurray JJV, et al. · 2019

BACKGROUND: In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent me…

Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

Fernando Dinali H., Forbes Josephine M., Angus Peter W., Herath Chandana B. · 2019

Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population and is now a major cause of liver disease-related premature illness and deaths in the world. Treatment is largely ba…

Diabetes-specific family conflict and responsibility among emerging adults with type 1 diabetes.

Campbell MS, et al. · 2019

Emerging adulthood is a transitional period for type 1 diabetes management, and aspects of family functioning such as family conflict and responsibility for diabetes management likely change following…

Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: Assessment of Causal Relations

Livesey Geoffrey, Taylor Richard, Livesey Helen F., Buyken Anette E., Jenkins David J. A., Augustin Livia S. A., Sievenpiper John L., Barclay Alan W. et al. · 2019

While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glyce…

Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies.

Jiao J, et al. · 2019

OBJECTIVE: To assess the association of dietary fatty acids with cardiovascular disease mortality and total mortality among patients with type 2 diabetes. DESIGN: Prospective, longitudinal cohort stud…

Dietary intervention strategies for ethnic Chinese women with gestational diabetes mellitus: A systematic review and meta‐analysis

Wan Ching S., Nankervis Alison, Teede Helena, Aroni Rosalie · 2019

Ethnic Chinese women are one of the populations at high risk of gestational diabetes mellitus (GDM) internationally. This systematic review aimed to determine which dietary intervention strategies wer…

Dietary patterns and management of type 2 diabetes: A systematic review of randomised clinical trials.

Papamichou D, et al. · 2019

BACKGROUND AND AIM: The aim of the present review is to examine evidence from published studies on the effectiveness of six or more months of low carbohydrate, macrobiotic, vegan, vegetarian, Mediterr…

Differential Impact of Food Insecurity, Distress, and Stress on Self-care Behaviors and Glycemic Control Using Path Analysis.

Walker RJ, et al. · 2019

BACKGROUND: The aim of this study was to investigate the direct and indirect pathways through which food insecurity influences glycemic control and self-care behaviors. METHODS: Using data collected f…

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial.

Lean MEJ, et al. · 2019

BACKGROUND: The DiRECT trial assessed remission of type 2 diabetes during a primary care-led weight-management programme. At 1 year, 68 (46%) of 149 intervention participants were in remission and 36 …

EADSG Guidelines: Insulin Storage and Optimisation of Injection Technique in Diabetes Management.

Bahendeka S, et al. · 2019

To date, insulin therapy remains the cornerstone of diabetes management; but the art of injecting insulin is still poorly understood in many health facilities. To address this gap, the Forum for Injec…

Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.

Rao M, et al. · 2019

BACKGROUND: Insulin resistance (IR) is a physiological condition related to type 2 diabetes mellitus (T2DM) and obesity, which is associated with high blood insulin and glucose. Inulin-type carbohydra…

Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial.

Salas-Salvadó J, et al. · 2019

OBJECTIVE: The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta…

Effectiveness of Following Mediterranean Diet Recommendations in the Real World in the Incidence of Gestational Diabetes Mellitus (GDM) and Adverse Maternal-Foetal Outcomes: A Prospective, Universal, Interventional Study with a Single Group. The St Carlos Study

García de la Torre Nuria, Assaf-Balut Carla, Jiménez Varas Inés, del Valle Laura, Durán Alejandra, Fuentes Manuel, del Prado Náyade, Bordiú Elena et al. · 2019

We reported that a Mediterranean Diet (MedDiet), supplemented with extra-virgin olive oil (EVOO) and pistachios, reduces GDM incidence and several other adverse outcomes. In order to assess its transl…

Efficacy of continuous positive airway pressure (CPAP) preventing type 2 diabetes mellitus in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and insulin resistance: a systematic review and meta-analysis.

Abud R, et al. · 2019

BACKGROUND: Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a very common, yet undiagnosed, breathing disorder that has many more implications besides disrupted sleep. Its role as an independent …

Estimating the effect of calorie menu labeling on calories purchased in a large restaurant franchise in the southern United States: quasi-experimental study.

Petimar J, et al. · 2019

OBJECTIVE: To evaluate whether calorie labeling of menus in large restaurant chains was associated with a change in mean calories purchased per transaction. DESIGN: Quasi-experimental longitudinal stu…

Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis.

Sampath Kumar A, et al. · 2019

BACKGROUND: Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the litera…

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

Russell Jordan T., Roesch Luiz F. W., Ördberg Malin, Ilonen Jorma, Atkinson Mark A., Schatz Desmond A., Triplett Eric W., Ludvigsson Johnny · 2019

Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in t…

Glycemic Index and Load of Selected Ethiopian Foods: An Experimental Study

Dereje Nebiyu, Bekele Gadise, Nigatu Yemisrach, Worku Yoseph, Holland Roger P. · 2019

Determining the glycemic index and load of foods has significant impact on meal planning for diabetes. However, there is no data on the glycemic index (GI) and glycemic load (GL) of Ethiopian foods. T…

High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths

De Chiara Francesco, Ureta Checcllo Cynthia, Ramón Azcón Javier · 2019

Non-alcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation within the liver affecting 1 in 4 people worldwide. As the new silent killer of the twenty-first century, NAFLD impacts…

Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults

Consitt Leslie A., Dudley Courtney, Saxena Gunjan · 2019

Aging is associated with insulin resistance and the development of type 2 diabetes. While this process is multifaceted, age-related changes to skeletal muscle are expected to contribute to impaired gl…

Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease

Perdomo Carolina M., Frühbeck Gema, Escalada Javier · 2019

Non-alcoholic fatty liver disease (NAFLD) is a major global health threat due to its growing incidence and prevalence. It is becoming the leading cause of liver disease in addition to its strong assoc…

Impact of alexithymia on glycemic control among Lebanese adults with type 2 diabetes.

Fares C, et al. · 2019

PURPOSE: Alexithymia, defined as the inability of a person to identify, describe and express emotions, has been found to influence glycemic control in type 2 diabetes patients (D2). The characteristic…

Intestinal Fructose and Glucose Metabolism in Health and Disease.

Merino B, et al. · 2019

The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by…

Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.

Wang L, et al. · 2019

BACKGROUND: Currently, many clinical trials have shown that inulin-type fructans (ITF) supplementation is associated with glycemic control; nevertheless, the results are inconclusive. The aim of this …

Liraglutide in Children and Adolescents with Type 2 Diabetes.

Tamborlane WV, et al. · 2019

BACKGROUND: Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in the disease. However, early loss of glycemic control has been observed with metformin …

Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial.

Athinarayanan SJ, et al. · 2019

Purpose: Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. We previously reported the effectiveness of a novel digitally-monitored continuous care inter…

Lower body mass index is not of more benefit for diabetic complications

Zhang Yongze, Guo Yangyang, Shen Ximei, Zhao Fengying, Yan Sunjie · 2019

To investigate the relationship between different body mass index ( BMI ) levels and vascular complications in type 2 diabetes mellitus patients. Data were collected from 3,224 individuals with type 2…

Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

Nogues Perrine, Dos Santos Esther, Jammes Hélène, Berveiller Paul, Arnould Lucie, Vialard François, Dieudonné Marie-Noëlle · 2019

It is well established that obesity is associated with dysregulation of the ratio between the two major adipokines leptin and adiponectin. Furthermore, it was recently reported that maternal obesity h…

Medically Tailored Meal Delivery for Diabetes Patients with Food Insecurity: a Randomized Cross-over Trial.

Berkowitz SA, et al. · 2019

BACKGROUND: Food insecurity, defined as inconsistent food access owing to cost, leads to poor health. OBJECTIVE: To test whether a medically tailored meal delivery program improved dietary quality in …

Microbiome and type 1 diabetes

Siljander Heli, Honkanen Jarno, Knip Mikael · 2019

The steep increase in the incidence of type 1 diabetes (T1D), in the Western world after World War II, cannot be explained solely by genetic factors but implies that this rise must be due to crucial i…

Milk A1 β-casein and health-related outcomes in humans: a systematic review.

Küllenberg de Gaudry D, et al. · 2019

CONTEXT: Various epidemiological studies suggest a positive association between exposure to cow's milk A1 β-casein protein and risk for noncommunicable chronic diseases. The consumption of A2 cow's mi…

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes

Hinder Lucy M., Sas Kelli M., O’Brien Phillipe D., Backus Carey, Kayampilly Pradeep, Hayes John M., Lin Cheng-mao, Zhang Hongyu et al. · 2019

Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients. The incidence of these compli…

Multicohort study of change in job strain, poor mental health and incident cardiometabolic disease.

Magnusson Hanson LL, et al. · 2019

OBJECTIVES: Several recent large-scale studies have indicated a prospective association between job strain and coronary heart disease, stroke and diabetes. Job strain is also associated with poorer me…

Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report.

Evert AB, et al. · 2019

(abstract non disponibile su PubMed)…

Periodontitis and diabetes.

Preshaw PM, et al. · 2019

Periodontitis and diabetes are complex chronic diseases, linked by an established bidirectional relationship. Risk for periodontitis is increased two to three times in people with diabetes compared to…

Perioperative diabetic ketoacidosis associated with sodium-glucose co-transporter-2 inhibitors: a systematic review.

Thiruvenkatarajan V, et al. · 2019

BACKGROUND: Perioperative diabetic ketoacidosis (DKA) with near-normal blood glucose concentrations, termed euglycaemic ketoacidosis (EDKA), is an adverse effect associated with sodium-glucose co-tran…

Prevention of Type 2 Diabetes by Lifestyle Changes: A Systematic Review and Meta-Analysis.

Uusitupa M, et al. · 2019

Prevention of type 2 diabetes (T2D) is a great challenge worldwide. The aim of this evidence synthesis was to summarize the available evidence in order to update the European Association for the Study…

Psychosocial Factors in Painful Diabetic Neuropathy: A Systematic Review of Treatment Trials and Survey Studies.

Kioskli K, et al. · 2019

OBJECTIVE: Diabetes mellitus is associated with a number of complications that can adversely impact patients' quality of life. A common and often painful complication is painful diabetic neuropathy. T…

Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis.

Gao C, et al. · 2019

BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. …

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic

Wahls Terry L., Chenard Catherine A., Snetselaar Linda G. · 2019

The precise etiology of multiple sclerosis (MS) is unknown but epidemiologic evidence suggests this immune-mediated, neurodegenerative condition is the result of a complex interaction between genes an…

Risk of diabetic ketoacidosis during Ramadan fasting: A critical reappraisal.

Beshyah SA, et al. · 2019

OBJECTIVES: To evaluate the validity of the perceived increased risk and the actual occurrence of DKA observed during fasting in Ramadan. METHODS: This is a non-systematic narrative review of the lite…

SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.

Zelniker TA, et al. · 2019

BACKGROUND: The magnitude of effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on specific cardiovascular and renal outcomes and whether heterogeneity is based on key baseline characteristi…

Sleep and Environmental Factors Affecting Glycemic Control in People with Type 2 Diabetes Mellitus.

Afroz-Hossain A, et al. · 2019

PURPOSE OF REVIEW: Sleep and environmental factors both impact glycemic control in persons with type 2 diabetes mellitus (T2DM). This narrative article aims to review research within the past 5 years,…

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.

Depommier C, et al. · 2019

Metabolic syndrome is characterized by a constellation of comorbidities that predispose individuals to an increased risk of developing cardiovascular pathologies as well as type 2 diabetes mellitus1. …

The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial

Zakerkish Mehrnoosh, Jenabi Maryam, Zaeemzadeh Narjes, Hemmati Ali Asghar, Neisi Niloofar · 2019

Propolis is a natural product with many biological properties including hypoglycemic activity and modulating lipid profile. The present study was designed to evaluate the effect of Iranian propolis ex…

The Role of Health Literacy in Diabetes Knowledge, Self-Care, and Glycemic Control: a Meta-analysis.

Marciano L, et al. · 2019

BACKGROUND: Empirical evidence on how health literacy affects diabetes outcomes is inconsistent. The purpose of this meta-analysis was to quantitatively summarize the findings on the associations betw…

The efficacy of myo-inositol supplementation to prevent gestational diabetes onset: a meta-analysis of randomized controlled trials.

Zhang H, et al. · 2019

INTRODUCTION: The efficacy of myo-inositol supplementation to prevent gestational diabetes onset remains controversial. We conducted a systematic review and meta-analysis to explore the influence of m…

The impact of food order on postprandial glycaemic excursions in prediabetes.

Shukla AP, et al. · 2019

Data suggest that nutrient order during a meal significantly impacts postprandial glucose and insulin excursions in type 2 diabetes, while its effects in prediabetes have not been reported. Fifteen pa…

The prevalence and clinical correlates of adverse childhood experiences in a cross-sectional study of primary care patients with cardiometabolic disease or risk factors.

Maunder RG, et al. · 2019

BACKGROUND: Adverse childhood experiences (ACEs) are associated with risk of poor adult health, including cardiometabolic diseases. Little is known about the correlates of ACEs for adults who have alr…

The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies.

Khaledi M, et al. · 2019

AIMS: Depression is a common co-morbidity in patients with type 2 diabetes mellitus (T2DM). Untreated depression in these patients adversely affects self-care activities and other diabetes complicatio…

The ups and downs of low-carbohydrate diets in the management of Type 1 diabetes: a review of clinical outcomes.

Seckold R, et al. · 2019

Dietary management has been a mainstay of care in Type 1 diabetes since before the discovery of insulin when severe carbohydrate restriction was advocated. The use of insulin facilitated re-introducti…

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.

Foretz M, et al. · 2019

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the mechanisms underlying the plasma glucose level-lowering effects of metformin (1,1-dimethylbiguanide) still re…

Understanding the mechanisms of reversal of type 2 diabetes.

Taylor R, et al. · 2019

Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver, excess fat w…

Vitamin D Supplementation and Prevention of Type 2 Diabetes.

Pittas AG, et al. · 2019

BACKGROUND: Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin D supplementation lowers the risk of di…

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Fernández-Cao JC, et al. · 2019

Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc int…

Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials.

Wang X, et al. · 2019

BACKGROUND: Although many studies have shown that low zinc status is associated with diabetes, the putative effects of zinc supplementation on glycemic control are inconclusive. OBJECTIVES: The aim of…

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.

Koeth RA, et al. · 2019

BACKGROUND: l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota-dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a mu…

A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial.

Braunstein CR, et al. · 2018

UNLABELLED: Recent literature suggests that catalytic doses (&le;10 g/meal or 36 g/day) of D-fructose and D-allulose may reduce postprandial blood glucose responses to carbohydrate loads in people wit…

A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus

Schwingshackl Lukas, Chaimani Anna, Hoffmann Georg, Schwedhelm Carolina, Boeing Heiner · 2018

The aim of the present study is to assess the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus using a systematic review of the liter…

ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus.

· 2018

Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. However, debate continues to surround the diagnosis and treatment of GDM despite several recent large-…

Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults

Supriya Rashmi, Tam Bjorn T., Yu Angus P., Lee Paul H., Lai Christopher W., Cheng Kenneth K., Yau Sonata Y., Chan Lawrence W. et al. · 2018

Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotei…

Adverse Childhood Experiences and the Risk of Diabetes: Examining the Roles of Depressive Symptoms and Cardiometabolic Dysregulations in the Whitehall II Cohort Study.

Deschênes SS, et al. · 2018

OBJECTIVE: Adverse childhood experiences (ACEs) are associated with an increased risk of diabetes in adulthood. However, the potential mediating roles of depression and cardiometabolic dysregulations …

Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies.

Burghardt KJ, et al. · 2018

Atypical antipsychotics increase the risk of diabetes and cardiovascular disease through their side effects of insulin resistance and weight gain. The populations for which atypical antipsychotics are…

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study.

Bhanpuri NH, et al. · 2018

BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significan…

Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis.

Carlström M, et al. · 2018

CONTEXT: Type 2 diabetes (T2D) is a major health problem worldwide that is associated with increased morbidity and mortality. There is increased interest in the value of different nutrition-based stra…

Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.

Inge TH, et al. · 2018

IMPORTANCE: Because of the substantial increase in the occurrence of type 2 diabetes in the pediatric population and the medical complications of this condition, therapies are urgently needed that wil…

Comparison of medication adherence and persistence in type 2 diabetes: A systematic review and meta-analysis.

McGovern A, et al. · 2018

Limited medication adherence and persistence with treatment are barriers to successful management of type 2 diabetes (T2D). We searched MEDLINE, EMBASE, the Cochrane Library, the Register of Controlle…

Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis.

Jakubowski KP, et al. · 2018

OBJECTIVE: Adverse childhood experiences may be associated with cardiometabolic morbidity and mortality in adulthood. There is heterogeneity in this literature regarding the type of items in cumulativ…

Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis.

Seidelmann SB, et al. · 2018

BACKGROUND: Low carbohydrate diets, which restrict carbohydrate in favour of increased protein or fat intake, or both, are a popular weight-loss strategy. However, the long-term effect of carbohydrate…

Effect of Food Order on Ghrelin Suppression.

Shukla AP, et al. · 2018

La domanda: si sapeva gia' che l'ordine dei cibi sposta glicemia, insulina e GLP-1 dopo il pasto. Restava da capire se tocca anche la GRELINA — l'ormone che segnala la fame — e quindi se l'ordine dei …

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.

Knip M, et al. · 2018

IMPORTANCE: Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed …

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.

Gardner CD, et al. · 2018

IMPORTANCE: Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype …

Effect of low-carbohydrate diet on markers of renal function in patients with type 2 diabetes: A meta-analysis.

Suyoto PST · 2018

Meta-analysis was conducted to clarify the effect of low-carbohydrate diet (LCD) on renal function in patients with type 2 diabetes. An extensive literature search was conducted on scientific database…

Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study.

Hallberg SJ, et al. · 2018

INTRODUCTION: Carbohydrate restriction markedly improves glycemic control in patients with type 2 diabetes (T2D) but necessitates prompt medication changes. Therefore, we assessed the effectiveness an…

Evaluation of Dietary Intakes and Nutritional Knowledge in Thai Patients with Type 2 Diabetes Mellitus

Thewjitcharoen Yotsapon, Chotwanvirat Phawinpon, Jantawan Annapann, Siwasaranond Nantaporn, Saetung Sunee, Nimitphong Hataikarn, Himathongkam Thep, Reutrakul Sirimon · 2018

Most nutritional guidelines for diabetes management emphasize the importance of having individualized goals, away from a one-size-fits-all approach. However, there is a dearth of information on the di…

Examining the Interrelations Among Objective and Subjective Health Literacy and Numeracy and Their Associations with Health Knowledge.

Waters EA, et al. · 2018

BACKGROUND: Health literacy and numeracy influence many health-related behaviors and outcomes. Health literacy and numeracy have been assessed objectively and subjectively, but interrelationships amon…

Exercise reduces body fat and improves insulin sensitivity and pancreatic β-cell function in overweight and obese male Taiwanese adolescents

Shih Kuang-Chung, Kwok Ching-Fai · 2018

Improvements in insulin resistance and pancreatic β-cell function have been shown following exercise in adults with obesity; however, few adolescent-based studies have been conducted. This study exami…

Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis.

Pan B, et al. · 2018

INTRODUCTION: Current international guidelines recommend aerobic, resistance, and combined exercises for the management of type 2 diabetes mellitus (T2DM). In our study, we conducted a network meta-an…

Food Insecurity, Food "Deserts," and Glycemic Control in Patients With Diabetes: A Longitudinal Analysis.

Berkowitz SA, et al. · 2018

OBJECTIVE: Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diab…

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.

Zhao L, et al. · 2018

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We…

Gut microbiome in type 1 diabetes: A comprehensive review

Zheng Peilin, Li Zhixia, Zhou Zhiguang · 2018

Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive fa…

Ileal digestibility of intrinsically labeled hen's egg and meat protein determined with the dual stable isotope tracer method in Indian adults.

Kashyap S, et al. · 2018

BACKGROUND: Protein quality assessment through the Digestible Indispensable Amino Acid Score requires accurate measurements of true ileal protein and amino acid digestibility, for which a dual isotope…

Immunogenicity, safety, and effectiveness of seasonal influenza vaccination in patients with diabetes mellitus: A systematic review.

Dos Santos G, et al. · 2018

Influenza is associated with an increased risk of complications, especially in diabetic mellitus patients who are more susceptible to influenza infection. Despite recommendations of the WHO and public…

Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.

· 2018

OBJECTIVE: Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metform…

Impact of a Mediterranean Dietary Pattern and Its Components on Cardiovascular Risk Factors, Glucose Control, and Body Weight in People with Type 2 Diabetes: A Real-Life Study

Vitale Marilena, Masulli Maria, Calabrese Ilaria, Rivellese Angela Albarosa, Bonora Enzo, Signorini Stefano, Perriello Gabriele, Squatrito Sebastiano et al. · 2018

This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people with…

Implementing a low-carbohydrate, ketogenic diet to manage type 2 diabetes mellitus.

Westman EC, et al. · 2018

INTRODUCTION: Type 2 diabetes mellitus (T2DM) has reached epidemic proportions in the modern world. For individuals affected by obesity-related T2DM, clinical studies have shown that carbohydrate rest…

Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile

Galarregui Cristina, Zulet María Ángeles, Cantero Irene, Marín-Alejandre Bertha Araceli, Monreal José Ignacio, Elorz Mariana, Benito-Boillos Alberto, Herrero José Ignacio et al. · 2018

Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet–disease relationships. The aim o…

Low-carbohydrate diets for type 1 diabetes mellitus: A systematic review.

Turton JL, et al. · 2018

Type 1 diabetes is an autoimmune condition characterised by pancreatic beta cell destruction and absolute insulin deficiency. The strongest predictor of diabetes complications is glycaemic control and…

Management of Type 1 Diabetes With a Very Low-Carbohydrate Diet.

Lennerz BS, et al. · 2018

OBJECTIVES: To evaluate glycemic control among children and adults with type 1 diabetes mellitus (T1DM) who consume a very low-carbohydrate diet (VLCD). METHODS: We conducted an online survey of an in…

Mechanisms of Insulin Action and Insulin Resistance.

Petersen MC, et al. · 2018

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matur…

Model to Determine Risk of Pancreatic Cancer in Patients With New-Onset Diabetes.

Sharma A, et al. · 2018

BACKGROUND & AIMS: Of patients with new-onset diabetes (NOD; based on glycemic status) older than 50 years, approximately 1% are diagnosed with pancreatic cancer (PC) within 3 years. We aimed to devel…

Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes.

Van Name MA, et al. · 2018

BACKGROUND: Fear of hypoglycemia is common in parents of young children with type 1 diabetes (T1D), but little is known about the specific fears that parents most often experience. Hypoglycemia fear h…

Optimal prandial timing of bolus insulin in diabetes management: a review.

Slattery D, et al. · 2018

The inability to achieve optimal diabetes glucose control in people with diabetes is multifactorial, but one contributor may be inadequate control of postprandial glucose. In patients treated with mul…

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.

Lean ME, et al. · 2018

BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2…

Relevance of the Glycemic Index and Glycemic Load for Body Weight, Diabetes, and Cardiovascular Disease

Vega-López Sonia, Venn Bernard J., Slavin Joanne L. · 2018

Despite initial enthusiasm, the relationship between glycemic index (GI) and glycemic response (GR) and disease prevention remains unclear. This review examines evidence from randomized, controlled tr…

Reproducibility and Validity of a Questionnaire Measuring Treatment Burden on Patients with Type 2 Diabetes: Diabetic Treatment Burden Questionnaire (DTBQ).

Ishii H, et al. · 2018

INTRODUCTION: To measure the burden of pharmacotherapy on patients with type 2 diabetes mellitus (T2DM), we developed the Diabetes Treatment Burden Questionnaire (DTBQ), a patient-administered questio…

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.

Bellou V, et al. · 2018

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have been suggested, but their ove…

Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology.

Sanz M, et al. · 2018

BACKGROUND: Diabetes and periodontitis are chronic non-communicable diseases independently associated with mortality and have a bidirectional relationship. AIMS: To update the evidence for their epide…

Short sleep duration and hyperglycemia in pregnancy: Aggregate and individual patient data meta-analysis.

Reutrakul S, et al. · 2018

Short sleep duration has been linked to maternal hyperglycemia. Systematic review and meta-analysis were performed to evaluate the relationship between sleep duration and hyperglycemia in pregnancy or…

Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial.

Romo-Romo A, et al. · 2018

BACKGROUND: Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned. OBJECTIVE: The aim of this study was to evaluate the effects of sucralose consumption on glucos…

Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial.

D'Aiuto F, et al. · 2018

BACKGROUND: Chronic inflammation is believed to be a major mechanism underlying the pathophysiology of type 2 diabetes. Periodontitis is a cause of systemic inflammation. We aimed to assess the effect…

The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study

Ngala Robert Amadu, Awe Martin Akilla, Nsiah Paul · 2018

The study was aimed at determining the effect of plasma chromium concentration on the metabolism of glucose, and lipids and their subsequent cardiovascular risk in patients with type 2 diabetes in the…

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

Vatanen Tommi, Franzosa Eric A., Schwager Randall, Tripathi Surya, Arthur Timothy D., Vehik Kendra, Lernmark Åke, Hagopian William A. et al. · 2018

Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors , including complex genetic elements , patient exposures and …

The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials.

Huntriss R, et al. · 2018

BACKGROUND/OBJECTIVES: Recently, the role of a low-carbohydrate diet in diabetes management has generated interest with claims being made regarding its superiority over the traditional high-carbohydra…

Type 1 Diabetic Subjects with Diabetic Retinopathy Show an Unfavorable Pattern of Fat Intake

Granado-Casas Minerva, Ramírez-Morros Anna, Martín Mariona, Real Jordi, Alonso Núria, Valldeperas Xavier, Traveset Alicia, Rubinat Esther et al. · 2018

Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabe…

Type 2 Diabetes and Thiazide Diuretics.

Scheen AJ · 2018

PURPOSE OF REVIEW: In patients with prediabetes or type 2 diabetes, the use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset…

Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects.

Klinman JP, et al. · 2018

Hydrogen atom transfer (HAT) is a salient feature of many enzymatic C-H cleavage mechanisms. In systems where kinetic isolation of HAT is achieved, selective labeling of substrate with hydrogen isotop…

A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention study

Assaf-Balut Carla, García de la Torre Nuria, Durán Alejandra, Fuentes Manuel, Bordiú Elena, del Valle Laura, Familiar Cristina, Ortolá Ana et al. · 2017

Gestational diabetes mellitus (GDM) prevalence is increasing and becoming a major public health concern. Whether a Mediterranean diet can help prevent GDM in unselected pregnant women has yet to be st…

A Systematic Review and Meta-analysis of Executive Function Performance in Type 1 Diabetes Mellitus.

Broadley MM, et al. · 2017

OBJECTIVE: The aims of the study were to examine the current evidence for executive function (EF) performance differences between groups with type 1 diabetes mellitus (T1DM) and nondiabetic control gr…

An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial

Saslow Laura R, Mason Ashley E, Kim Sarah, Goldman Veronica, Ploutz-Snyder Robert, Bayandorian Hovig, Daubenmier Jennifer, Hecht Frederick M et al. · 2017

Type 2 diabetes is a prevalent, chronic disease for which diet is an integral aspect of treatment. In our previous trial, we found that recommendations to follow a very low-carbohydrate ketogenic diet…

An Overview of Dietary Interventions and Strategies to Optimize the Management of Non-Alcoholic Fatty Liver Disease

Perumpail Brandon J., Cholankeril Rosann, Yoo Eric R., Kim Donghee, Ahmed Aijaz · 2017

Aim: To investigate the efficacy of lifestyle adjustment strategies as a preventive measure and/or treatment of obesity-related non-alcoholic fatty liver disease in adults. Method: A systematic review…

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study.

Dehghan M, et al. · 2017

BACKGROUND: The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition exce…

Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses.

Korem T, et al. · 2017

Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is contradicting. Here, we performed a randomized crossover trial of two 1-week-long dietary interventions co…

Canagliflozin, dapagliflozin and empagliflozin monotherapy for treating type 2 diabetes: systematic review and economic evaluation.

Johnston R, et al. · 2017

BACKGROUND: Most people with type 2 diabetes are overweight, so initial treatment is aimed at reducing weight and increasing physical activity. Even modest weight loss can improve control of blood glu…

Carbohydrate-last meal pattern lowers postprandial glucose and insulin excursions in type 2 diabetes.

Shukla AP, et al. · 2017

BACKGROUND: There are limited data regarding the timing of carbohydrate ingestion during a meal and postprandial glucose regulation. METHODS: Sixteen subjects with type 2 diabetes mellitus (T2DM) cons…

Carbohydrates from Sources with a Higher Glycemic Index during Adolescence: Is Evening Rather than Morning Intake Relevant for Risk Markers of Type 2 Diabetes in Young Adulthood?

Diederichs Tanja, Herder Christian, Roßbach Sarah, Roden Michael, Wudy Stefan A., Nöthlings Ute, Alexy Ute, Buyken Anette E. · 2017

Background: This study investigated whether glycemic index (GI) or glycemic load (GL) of morning or evening intake and morning or evening carbohydrate intake from low- or higher-GI food sources (low-G…

Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis.

Storhaug CL, et al. · 2017

BACKGROUND: Studies have shown wide variation in the prevalence of lactose malabsorption across the world, but no systematic reviews or meta-analyses have recently assessed the prevalence of lactose m…

Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease

Eslamparast Tannaz, Tandon Puneeta, Raman Maitreyi · 2017

Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrate…

Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis

Shrestha Archana, Karmacharya Biraj Man, Khudyakov Polyna, Weber Mary Beth, Spiegelman Donna · 2017

The translation of lifestyle intervention to improve glucose tolerance into the workplace has been rare. The objective of this meta-analysis is to summarize the evidence for the effectiveness of dieta…

Effect of iron deficiency anemia and iron supplementation on HbA1c levels - Implications for diagnosis of prediabetes and diabetes mellitus in Asian Indians.

Madhu SV, et al. · 2017

BACKGROUND: We investigated the effect of iron deficiency anemia (IDA) on levels of glycated hemoglobin (HbA1c) and to compare its levels before and after iron supplementations. METHODS: Age and sex m…

Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients.

Talaei B, Amouzegar A, Sahranavard S, Hedayati M, Mirmiran P, Azizi F · 2017

The aim of the current study was to determine the effect of a daily intake of three grams of cinnamon over eight weeks on glycemic indicators, advanced glycation end products, and antioxidant status i…

Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake.

Tey SL, et al. · 2017

BACKGROUND: Substituting sweeteners with non-nutritive sweeteners (NNS) may aid in glycaemic control and body weight management. Limited studies have investigated energy compensation, glycaemic and in…

Executive Function in Adolescents With Type 1 Diabetes: Relationship to Adherence, Glycemic Control, and Psychosocial Outcomes.

Perez KM, et al. · 2017

Impairments in executive function (EF) skills have been observed in youth with type 1 diabetes (T1D), and these skills are critical for following the complex treatment regimen. This study examines par…

Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

Fernandez-Twinn Denise S., Gascoin Geraldine, Musial Barbara, Carr Sarah, Duque-Guimaraes Daniella, Blackmore Heather L., Alfaradhi Maria Z., Loche Elena et al. · 2017

The prevalence of obesity during pregnancy continues to increase at alarming rates. This is concerning as in addition to immediate impacts on maternal wellbeing, obesity during pregnancy has detriment…

Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia

Goguet-Rubio Perrine, Klug Rebecca L., Sharma Dana L., Srikanthan Krithika, Puri Nitin, Lakhani Vishal H, Nichols Alexandra, O'Hanlon Kathleen M. et al. · 2017

Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) a…

Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies.

Schwingshackl L, et al. · 2017

The aim of this systematic review and meta-analysis was to synthesize the knowledge about the relation between intake of 12 major food groups and risk of type 2 diabetes (T2D). We conducted a systemat…

Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Jung Chan-Hee, Choi Kyung Mook · 2017

In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate…

Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study.

Woodmansey C, et al. · 2017

OBJECTIVE: This study was conducted to describe the incidence of diabetes following pancreatic disease, assess how these patients are classified by clinicians, and compare clinical characteristics wit…

International Consensus on Use of Continuous Glucose Monitoring.

Danne T, et al. · 2017

Measurement of glycated hemoglobin (HbA1c) has been the traditional method for assessing glycemic control. However, it does not reflect intra- and interday glycemic excursions that may lead to acute e…

Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study

Chen Sijing, Jin Xiaoling, Shan Zhilei, Li Shuzhen, Yin Jiawei, Sun Taoping, Luo Cheng, Yang Wei et al. · 2017

Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study ai…

Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals

Della Pepa Giuseppe, Vetrani Claudia, Lombardi Gianluca, Bozzetto Lutgarda, Annuzzi Giovanni, Rivellese Angela Albarosa · 2017

Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (…

Lived experience of blood glucose self-monitoring among pregnant women with gestational diabetes mellitus: a phenomenological research.

Youngwanichsetha S, et al. · 2017

AIMS AND OBJECTIVES: To explore and describe lived experience of blood glucose self-monitoring among pregnant Thai women with gestational diabetes mellitus. BACKGROUND: Self-monitoring of blood glucos…

Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis.

Altobelli E, et al. · 2017

Irritable bowel syndrome (IBS) affects 7-15% of the general population. A recently devised dietary approach consists of restricting foods with highly fermentable oligo-, di-, and monosaccharides, and …

Measuring Type 1 diabetes stigma: development and validation of the Type 1 Diabetes Stigma Assessment Scale (DSAS-1).

Browne JL, et al. · 2017

AIMS: To develop and validate a self-report measure designed to assess perceived and experienced stigma for adults with Type 1 diabetes: the Type 1 Diabetes Stigma Assessment Scale (DSAS-1). METHODS: …

Metformin: New Preparations and Nonglycemic Benefits.

Fujita Y, et al. · 2017

Metformin has been widely used for over 5 decades. New preparations have been developed for possible enhancement of efficiency, tolerability, and pleiotropic nonglycemic effects. Extended-release metf…

Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.

Azad MB, et al. · 2017

BACKGROUND: Nonnutritive sweeteners, such as aspartame, sucralose and stevioside, are widely consumed, yet their long-term health impact is uncertain. We synthesized evidence from prospective studies …

Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study

Zachariah Justin P., Quiroz Rene, Nelson Kerrie P., Teng Zhaoyang, Keaney John F., Sullivan Lisa M., Vasan Ramachandran S. · 2017

Adipokines are elaborated by adipose tissue and are associated with glycemic, lipid, and vascular traits. We hypothesized that in a cross‐sectional analysis circulating adipokines are altered among su…

Randomized Trial of the Effect of Mindfulness-Based Stress Reduction on Pain-Related Disability, Pain Intensity, Health-Related Quality of Life, and A1C in Patients With Painful Diabetic Peripheral Neuropathy.

Nathan HJ, et al. · 2017

IN BRIEF Painful diabetic peripheral neuropathy (PDPN) has a large negative impact on patients' physical and mental functioning, and pharmacological therapies rarely provide more than partial relief. …

Short- and medium-term effects of light to moderate alcohol intake on glycaemic control in diabetes mellitus: a systematic review and meta-analysis of randomized trials.

Hirst JA, et al. · 2017

BACKGROUND: People with diabetes are told that drinking alcohol may increase their risk of hypoglycaemia. AIMS: To report the effects of alcohol consumption on glycaemic control in people with diabete…

Sleep in children with type 1 diabetes and their parents in the T1D Exchange.

Jaser SS, et al. · 2017

OBJECTIVES: Sleep has physiological and behavioral impacts on diabetes outcomes, yet little is known about the impact of sleep disturbances in children with type 1 diabetes. The current study sought t…

Sugar in Infants, Children and Adolescents: A Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition.

Fidler Mis N, et al. · 2017

The consumption of sugars, particularly sugar-sweetened beverages (SSBs; beverages or drinks that contain added caloric sweeteners (ie, sucrose, high-fructose corn syrup, fruit juice concentrates), in…

The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis.

Hughes K, et al. · 2017

BACKGROUND: A growing body of research identifies the harmful effects that adverse childhood experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or exposure to domesti…

The impact of low and no-caloric sweeteners on glucose absorption, incretin secretion, and glucose tolerance.

Chan CB, et al. · 2017

The consumption of non-nutritive, low, or no-calorie sweeteners (LCS) is increasing globally. Previously thought to be physiologically inert, there is a growing body of evidence that LCS not only prov…

The impact of sleep amount and sleep quality on glycemic control in type 2 diabetes: A systematic review and meta-analysis.

Lee SWH, et al. · 2017

Recent epidemiological studies have suggested that there is an association between glycemic control and sleep disturbances in patients with type 2 diabetes, but the extent is unclear. A systematic lit…

The prevalence of diabetes-specific emotional distress in people with Type 2 diabetes: a systematic review and meta-analysis.

Perrin NE, et al. · 2017

AIMS: Psychological comorbidity, such as depression and/or diabetes-specific emotional distress (diabetes distress), is widespread in people with Type 2 diabetes and is associated with poorer treatmen…

Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes

Saslow Laura R., Daubenmier Jennifer J., Moskowitz Judith T., Kim Sarah, Murphy Elizabeth J., Phinney Stephen D., Ploutz-Snyder Robert, Goldman Veronica et al. · 2017

Dietary treatment is important in management of type 2 diabetes or prediabetes, but uncertainty exists about the optimal diet. We randomized adults ( n = 34) with glycated hemoglobin (HbA1c) > 6.0% an…

Type 1 Diabetes Mellitus and Cognitive Impairments: A Systematic Review.

Li W, et al. · 2017

Type 1 diabetes mellitus (T1DM) is a major subtype of diabetes and is usually diagnosed at a young age with insulin deficiency. The life expectancy of T1DM patients has increased substantially in comp…

Type 2 diabetes mellitus and psychological stress - a modifiable risk factor.

Hackett RA, et al. · 2017

Psychological stress is common in many physical illnesses and is increasingly recognized as a risk factor for disease onset and progression. An emerging body of literature suggests that stress has a r…

Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials.

Shishehbor F, et al. · 2017

OBJECTIVE: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in seve…

What is diabetes distress and how can we measure it? A narrative review and conceptual model.

Dennick K, et al. · 2017

BACKGROUND: Diabetes distress is the negative emotional impact of living with diabetes. It has tangible clinical importance, being associated with sub-optimal self-care and glycemic control. Diabetes …

Zinc Supplementation Improves Glucose Homeostasis in High Fat-Fed Mice by Enhancing Pancreatic β-Cell Function

Cooper-Capetini Vinícius, de Vasconcelos Diogo Antonio Alves, Martins Amanda Roque, Hirabara Sandro Massao, Donato José, Carpinelli Angelo Rafael, Abdulkader Fernando · 2017

Zinc is an essential component of the insulin granule and it possibly modulates insulin secretion and signaling. Since insulin resistance is a hallmark in the development of type 2 diabetes mellitus, …

A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes

Soare A, Del Toro R, Khazrai Y M, Di Mauro A, Fallucca S, Angeletti S, Skrami E, Gesuita R et al. · 2016

In the MADIAB trial (a 21-day randomized, controlled trial in patients with type 2 diabetes (T2D)), intervention with the Ma-Pi 2 macrobiotic diet resulted in significantly greater improvements in met…

A Randomized Controlled Trial of Acceptance and Commitment Therapy for Type 2 Diabetes Management: The Moderating Role of Coping Styles.

Shayeghian Z, et al. · 2016

BACKGROUND AND AIM: Evidence of the efficacy of existing psychological interventions for self-management in diabetes is limited. The current study aimed at assessing the effects of group-based ACT on …

A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol

Papamiltiadous Elena S., Roberts Stuart K., Nicoll Amanda J., Ryan Marno C., Itsiopoulos Catherine, Salim Agus, Tierney Audrey C. · 2016

Non-alcoholic fatty liver disease, the most prevalent liver disease in developed countries, remains difficult to manage with no proven safe and effective pharmacotherapy available. While weight reduct…

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY.

Garvey WT, et al. · 2016

OBJECTIVE: Development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and the American College of Endocrinology (ACE) Board of Trust…

Alexithymia in patients with type 2 diabetes mellitus: the role of anxiety, depression, and glycemic control.

Avci D, et al. · 2016

OBJECTIVE: This study was aimed at determining the prevalence of alexithymia in patients with type 2 DM and the factors affecting it. METHODS: This cross-sectional study was conducted with 326 patient…

Artificially Sweetened Beverage Consumption Is Positively Associated with Newly Diagnosed Diabetes in Normal-Weight but Not in Overweight or Obese Brazilian Adults.

Yarmolinsky J, et al. · 2016

BACKGROUND: Recent animal studies suggest that artificially sweetened beverage (ASB) consumption increases diabetes risk. OBJECTIVE: We examined the relation of ASB intake with newly diagnosed diabete…

Association between diabetes and risk of suicide death: A meta-analysis of 3 million participants.

Wang Y, et al. · 2016

BACKGROUND: Results of the relationships between diabetes and the risk of suicide death are inconclusive. This meta-analysis was conducted to assess this association. METHODS: We systematically search…

Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis.

Chapman LE, et al. · 2016

AIM: Metformin is the most widely used oral hypoglycaemic drug, but it may lower B12 status, which could have important clinical implications. We undertook a systematic review and meta-analysis of the…

Cardiometabolic Health in Submariners Returning from a 3-Month Patrol

Gasier Heath G., Young Colin R., Gaffney-Stomberg Erin, McAdams Douglas C., Lutz Laura J., McClung James P. · 2016

Confined space, limited exercise equipment, rotating shift work and reduced sleep may affect cardiometabolic health in submariners. To test this hypothesis, 53 male U.S. Submariners (20–39 years) were…

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut.

Roager HM, et al. · 2016

Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has r…

Consumption of Meals Prepared at Home and Risk of Type 2 Diabetes: An Analysis of Two Prospective Cohort Studies.

Zong G, et al. · 2016

BACKGROUND: There has been a trend towards increased dining out in many countries. Consuming food prepared out of the home has been linked to poor diet quality, weight gain, and diabetes risk, but whe…

Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis.

Vancampfort D, et al. · 2016

Type 2 diabetes mellitus (T2DM) is highly predictive of cardiovascular diseases and can have particularly deleterious health impacts in people with severe mental illness (SMI), i.e. schizophrenia, bip…

Diabetes self-management education for adults with type 2 diabetes mellitus: A systematic review of the effect on glycemic control.

Chrvala CA, et al. · 2016

OBJECTIVE: Assess effect of diabetes self-management education and support methods, providers, duration, and contact time on glycemic control in adults with type 2 diabetes. METHOD: We searched MEDLIN…

Dietary Strategies Implicated in the Prevention and Treatment of Metabolic Syndrome

de la Iglesia Rocio, Loria-Kohen Viviana, Zulet Maria Angeles, Martinez Jose Alfredo, Reglero Guillermo, Ramirez de Molina Ana · 2016

Metabolic syndrome (MetS) is established as the combination of central obesity and different metabolic disturbances, such as insulin resistance, hypertension and dyslipidemia. This cluster of factors …

Effects of a Multicomponent Life-Style Intervention on Weight, Glycemic Control, Depressive Symptoms, and Renal Function in Low-Income, Minority Patients With Type 2 Diabetes: Results of the Community Approach to Lifestyle Modification for Diabetes Randomized Controlled Trial

Moncrieft Ashley E., Llabre Maria M., McCalla Judith Rey, Gutt Miriam, Mendez Armando J., Gellman Marc D., Goldberg Ronald B., Schneiderman Neil · 2016

Supplemental digital content is available in the text. Few interventions have combined life-style and psychosocial approaches in the context of Type 2 diabetes management. The purpose of this study wa…

Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk.

Jianqin S, et al. · 2016

BACKGROUND: Cows' milk generally contains two types of β-casein, A1 and A2 types. Digestion of A1 type can yield the peptide β-casomorphin-7, which is implicated in adverse gastrointestinal effects of…

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.

Wanner C, et al. · 2016

BACKGROUND: Diabetes confers an increased risk of adverse cardiovascular and renal events. In the EMPA-REG OUTCOME trial, empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced the risk of…

Fear of hypoglycemia in adults with type 1 diabetes: impact of therapeutic advances and strategies for prevention - a review.

Martyn-Nemeth P, et al. · 2016

PURPOSE: This review summarizes the current state of the science related to fear of hypoglycemia (FOH) in adults with type 1 diabetes. Fear of hypoglycemia is a critical deterrent to diabetes self-man…

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.

Younossi ZM, et al. · 2016

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide. We estimated the global prevalence, incidence, progression, and outcomes of NAFLD and nonalcoholic ste…

Health consequences of shift work and insufficient sleep.

Kecklund G, et al. · 2016

This review summarises the literature on shift work and its relation to insufficient sleep, chronic diseases, and accidents. It is based on 38 meta-analyses and 24 systematic reviews, with additional …

Health-Care Costs, Glycemic Control and Nutritional Status in Malnourished Older Diabetics Treated with a Hypercaloric Diabetes-Specific Enteral Nutritional Formula

Sanz-Paris Alejandro, Boj-Carceller Diana, Lardies-Sanchez Beatriz, Perez-Fernandez Leticia, Cruz-Jentoft Alfonso J. · 2016

Diabetes-specific formulas are an effective alternative for providing nutrients and maintaining glycemic control. This study assesses the effect of treatment with an oral enteral nutrition with a hype…

Health-Literacy-Sensitive Diabetes Self-Management Interventions: A Systematic Review and Meta-Analysis.

Kim SH, et al. · 2016

BACKGROUND: Low health literacy is a potential barrier to self-management among patients with diabetes. A variety of strategies for low health literacy have been proposed for diabetes self-management …

Initial Combination of Empagliflozin and Metformin in Patients With Type 2 Diabetes.

Hadjadj S, et al. · 2016

OBJECTIVE: This study compared the efficacy and safety of initial combinations of empagliflozin + metformin with empagliflozin and metformin monotherapy in patients with type 2 diabetes. RESEARCH DESI…

Management of children with type 1 diabetes during illness: a national survey.

Soni A, et al. · 2016

AIM: Adequate sick-day management at home can reduce the risk of progression to diabetic ketoacidosis and admission to hospital. The aim of this project was to review the management of diabetes during…

Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways

Zhang Qian, Sun Xiaofang, Xiao Xinhua, Zheng Jia, Li Ming, Yu Miao, Ping Fan, Wang Zhixin et al. · 2016

An adverse intrauterine environment, induced by a chromium-restricted diet, is a potential cause of metabolic disease in adult life. Up to now, the relative mechanism has not been clear. C57BL female …

Measuring the Stigma Surrounding Type 2 Diabetes: Development and Validation of the Type 2 Diabetes Stigma Assessment Scale (DSAS-2).

Browne JL, et al. · 2016

OBJECTIVE: To develop and validate a self-report measure of perceived and experienced stigma for use with adults with type 2 diabetes: the Type 2 Diabetes Stigma Assessment Scale (DSAS-2). RESEARCH DE…

Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis.

de Silva VA, et al. · 2016

BACKGROUND: Most antipsychotics are associated with weight gain and other metabolic complications. Several randomized trials have shown metformin to be effective, but this still hasn't been included i…

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling.

Brand MD · 2016

This review examines the generation of reactive oxygen species by mammalian mitochondria, and the status of different sites of production in redox signaling and pathology. Eleven distinct mitochondria…

New Insulin Delivery Recommendations.

Frid AH, et al. · 2016

Many primary care professionals manage injection or infusion therapies in patients with diabetes. Few published guidelines have been available to help such professionals and their patients manage thes…

Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomised controlled trials.

Goldie C, et al. · 2016

OBJECTIVE: Previous studies have suggested that niacin treatment raises glucose levels in patients with diabetes and may increase the risk of developing diabetes. We undertook a meta-analysis of publi…

Peer Support Interventions for Adults With Diabetes: A Meta-Analysis of Hemoglobin A1c Outcomes.

Patil SJ, et al. · 2016

PURPOSE: Peer support intervention trials have shown varying effects on glycemic control. We aimed to estimate the effect of peer support interventions delivered by people affected by diabetes (those …

Physical activity and incident type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of prospective cohort studies.

Smith AD, et al. · 2016

AIMS/HYPOTHESIS: Inverse associations between physical activity (PA) and type 2 diabetes mellitus are well known. However, the shape of the dose-response relationship is still uncertain. This review s…

Potassium Intake, Bioavailability, Hypertension, and Glucose Control.

Stone MS, et al. · 2016

Potassium is an essential nutrient. It is the most abundant cation in intracellular fluid where it plays a key role in maintaining cell function. The gradient of potassium across the cell membrane det…

Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis.

Samah S, et al. · 2016

AIMS: To systematically review evidence of probiotic interventions against type 2 diabetes mellitus (T2DM) and analyse the effects of probiotics on glycaemic control among T2DM patients. METHODS: Elec…

Psychological and personality factors in type 2 diabetes mellitus, presenting the rationale and exploratory results from The Maastricht Study, a population-based cohort study.

van Dooren FE, et al. · 2016

BACKGROUND: Strong longitudinal evidence exists that psychological distress is associated with a high morbidity and mortality risk in type 2 diabetes. Little is known about the biological and behavior…

Review article: insights into colonic protein fermentation, its modulation and potential health implications.

Yao CK, et al. · 2016

BACKGROUND: Beneficial effects of carbohydrate fermentation on gastrointestinal health are well established. Conversely, protein fermentation generates harmful metabolites but their relevance to gastr…

SGLT2 Inhibitor-associated Diabetic Ketoacidosis: Clinical Review and Recommendations for Prevention and Diagnosis.

Goldenberg RM, et al. · 2016

PURPOSE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the newest class of antihyperglycemic agents available on the market. Regulator warnings and concerns regarding the risk of developing di…

Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus

Goday A, Bellido D, Sajoux I, Crujeiras A B, Burguera B, García-Luna P P, Oleaga A, Moreno B et al. · 2016

The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. Evaluating the short-term safety and to…

Sick Day Management in Children and Adolescents with Type 1 Diabetes.

Choudhary A · 2016

Diabetic Ketoacidosis (DKA) has high morbidity and mortality and can be prevented. It is extremely important to give clear guidance to patients and families on how to manage diabetes during intercurre…

Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis.

Reutrakul S, et al. · 2016

OBJECTIVES: The association between inadequate sleep and type 2 diabetes has garnered much attention, but little is known about sleep and type 1 diabetes (T1D). Our objectives were to conduct a system…

Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis.

Anothaisintawee T, et al. · 2016

Sleep disturbances [short (<6 h) and long (>8 h) sleeping time, insomnia (initiating or maintaining sleep), obstructive sleep apnea (OSA) and abnormal sleep timing] have been associated with increased…

Statin-Associated Diabetes Mellitus: Review and Clinical Guide.

Backes JM, et al. · 2016

A small but significant link between new-onset diabetes mellitus (NOD) and statin therapy was noted with rosuvastatin users in the Justification for the Use of Statins in Primary Prevention: An Interv…

Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals

Botezelli José D., Coope Andressa, Ghezzi Ana C., Cambri Lucieli T., Moura Leandro P., Scariot Pedro P. M., Gaspar Rodrigo Stellzer, Mekary Rania A. et al. · 2016

The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into fiv…

Sugars, obesity, and cardiovascular disease: results from recent randomized control trials.

Rippe JM, et al. · 2016

The relationship between sugar consumption and various health-related sequelas is controversial. Some investigators have argued that excessive sugar consumption is associated with increased risk of ob…

Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Srikanthan Krithika, Feyh Andrew, Visweshwar Haresh, Shapiro Joseph I., Sodhi Komal · 2016

Introduction: Metabolic syndrome represents a cluster of related metabolic abnormalities, including central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance, with central obe…

The Radical-Pair Mechanism of Magnetoreception.

Hore PJ, et al. · 2016

Although it has been known for almost half a century that migratory birds can detect the direction of the Earth's magnetic field, the primary sensory mechanism behind this remarkable feat is still unc…

Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production

Endesfelder David, Engel Marion, Davis-Richardson Austin G., Ardissone Alexandria N., Achenbach Peter, Hummel Sandra, Winkler Christiane, Atkinson Mark et al. · 2016

The development of anti-islet cell autoimmunity precedes clinical type 1 diabetes and occurs very early in life. During this early period, dietary factors strongly impact on the composition of the gut…

Transition of care for adolescents from paediatric services to adult health services.

Campbell F, et al. · 2016

BACKGROUND: There is evidence that the process of transition from paediatric (child) to adult health services is often associated with deterioration in the health of adolescents with chronic condition…

Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer.

Hart PA, et al. · 2016

Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by …

Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies.

Morgan E, et al. · 2016

AIMS/HYPOTHESIS: The aim of this study was to investigate the association between routine vaccinations and the risk of childhood type 1 diabetes mellitus by systematically reviewing the published lite…

Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome

Tochikubo O, Nakamura H, Jinzu H, Nagao K, Yoshida H, Kageyama N, Miyano H · 2016

The prevalence of metabolic syndrome is increasing worldwide, especially in Asian populations. Early detection and effective intervention are vital. Plasma free amino acid profile is a potential bioma…

Worldwide Injection Technique Questionnaire Study: Injecting Complications and the Role of the Professional.

Frid AH, et al. · 2016

From February 1, 2014, through June 30, 2015, 13,289 insulin-injecting patients from 423 centers in 42 countries participated in one of the largest surveys ever performed in diabetes. The first result…

A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses.

Esposito K, et al. · 2015

OBJECTIVES: To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states. DESIGN: A systematic review of all meta-analyses and rando…

Anti-diabetic potential of chromium histidinate in diabetic retinopathy rats

Ulas Mustafa, Orhan Cemal, Tuzcu Mehmet, Ozercan Ibrahim Hanifi, Sahin Nurhan, Gencoglu Hasan, Komorowski James R, Sahin Kazim · 2015

Chromium (Cr) is commonly used as a complementary medicine for diabetes mellitus. Several studies suggest that Cr intakes may improve glucose metabolism and decrease oxidative stress. Therefore, we ai…

Breakfast skipping and the risk of type 2 diabetes: a meta-analysis of observational studies.

Bi H, et al. · 2015

OBJECTIVE: Breakfast skipping has been reported to be associated with type 2 diabetes (T2D), but the results are inconsistent. No meta-analyses have applied quantitative techniques to compute summary …

Breastfeeding and maternal health outcomes: a systematic review and meta-analysis.

Chowdhury R, et al. · 2015

AIM: To evaluate the effect of breastfeeding on long-term (breast carcinoma, ovarian carcinoma, osteoporosis and type 2 diabetes mellitus) and short-term (lactational amenorrhoea, postpartum depressio…

Carcinogenicity of consumption of red and processed meat.

Bouvard V, et al. (IARC Monograph Working Group) · 2015

Valutazione IARC (monografia volume 114) sulla cancerogenicita' del consumo di carne rossa e carne lavorata, condotta da 22 esperti di 10 paesi su oltre 800 studi epidemiologici. La CARNE LAVORATA — s…

Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial.

Tay J, et al. · 2015

BACKGROUND: Few well-controlled studies have comprehensively examined the effects of very-low-carbohydrate diets on type 2 diabetes (T2D). OBJECTIVE: We compared the effects of a very-low-carbohydrate…

Constructs of depression and distress in diabetes: time for an appraisal.

Snoek FJ, et al. · 2015

Depression presents in roughly 20% of people with diabetes worldwide, and adversely affects quality of life and treatment outcomes. The causes of depression in diabetes are poorly understood, but rese…

Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction.

Imamura F, et al. · 2015

OBJECTIVES: To examine the prospective associations between consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice with type 2 diabetes before and after adjustment…

Contribution of hyperglycemia on diabetic complications in obese type 2

KATSUDA Yoshiaki, SASASE Tomohiko, TADAKI Hironobu, MERA Yasuko, MOTOHASHI Yu, KEMMOCHI Yusuke, TOYODA Kaoru, KAKIMOTO Kochi et al. · 2015

The spontaneously diabetic torii (SDT) fatty rat is a new model of type 2 diabetes showing overt obesity, hyperglycemia and hyperlipidemia. With early onset of diabetes mellitus, diabetic microvascula…

Diabetes mellitus and severe mental illness: mechanisms and clinical implications.

Holt RI, et al. · 2015

The prevalence of diabetes mellitus is twofold to threefold higher in people with severe mental illness (SMI) than in the general population, with diabetes mellitus affecting ∼12% of people receiving …

Diabetes-related emotional distress instruments: a systematic review of measurement properties.

Lee J, et al. · 2015

OBJECTIVES: The objectives of this study were to identify all available diabetes-related emotional distress instruments and evaluate the evidence regarding their measurement properties to help in the …

Differential effects of leptin on adiponectin expression with weight gain versus obesity

Singh Prachi, Sharma Pragya, Sahakyan Karine R., Davison Diane E., Sert-Kuniyoshi Fatima H, Romero-Corral Abel, Swain James M., Jensen Michael D. et al. · 2015

Adiponectin exerts beneficial effects by reducing inflammation, and improving lipid metabolism and insulin-sensitivity. Although adiponectin is lower in obese individuals, whether weight gain reduces …

Drug-Induced Hyperglycaemia and Diabetes.

Fathallah N, et al. · 2015

Drug-induced hyperglycaemia and diabetes is a global issue. It may be a serious problem, as it increases the risk of microvascular and macrovascular complications, infections, metabolic coma and even …

Effect of cooling of cooked white rice on resistant starch content and glycemic response.

Sonia S, et al. · 2015

Cooling of cooked starch is known to cause starch retrogradation which increases resistant starch content. This study aimed to determine the effect of cooling of cooked white rice on resistant starch …

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

Zinman B, et al. · 2015

BACKGROUND: The effects of empagliflozin, an inhibitor of sodium-glucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes at hi…

Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium-Glucose Cotransporter 2 Inhibition.

Peters AL, et al. · 2015

OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ketoacidosi…

Fear of needles in children with type 1 diabetes mellitus on multiple daily injections and continuous subcutaneous insulin infusion.

Cemeroglu AP, et al. · 2015

OBJECTIVE: To assess the prevalence of fear of needles and its effect on glycemic control in children with type 1 diabetes mellitus (T1DM) on multiple daily injections (MDI) or continuous subcutaneous…

Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels.

Shukla AP, et al. · 2015

(abstract non disponibile su PubMed)…

Head-to-head comparison of intensive lifestyle intervention (U-TURN) versus conventional multifactorial care in patients with type 2 diabetes: protocol and rationale for an assessor-blinded, parallel group and randomised trial

Ried-Larsen Mathias, Christensen Robin, Hansen Katrine B, Johansen Mette Y, Pedersen Maria, Zacho Morten, Hansen Louise S, Kofoed Katja et al. · 2015

Current pharmacological therapies in patients with type 2 diabetes (T2D) are challenged by lack of sustainability and borderline firm evidence of real long-term health benefits. Accordingly, lifestyle…

Impact of fat, protein, and glycemic index on postprandial glucose control in type 1 diabetes: implications for intensive diabetes management in the continuous glucose monitoring era.

Bell KJ, et al. · 2015

BACKGROUND: Continuous glucose monitoring highlights the complexity of postprandial glucose patterns present in type 1 diabetes and points to the limitations of current approaches to mealtime insulin …

Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension.

Lan J, et al. · 2015

ETHNOPHARMACOLOGICAL RELEVANCE: Berberine, extracted from Coptis Root and Phellodendron Chinese, has been frequently used for the adjuvant treatment of type 2 diabetes mellitus, hyperlipidemia, and hy…

Milk Intolerance, Beta-Casein and Lactose.

Pal S, et al. · 2015

True lactose intolerance (symptoms stemming from lactose malabsorption) is less common than is widely perceived, and should be viewed as just one potential cause of cows' milk intolerance. There is in…

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

Zhang Xu, Zhao Yufeng, Xu Jia, Xue Zhengsheng, Zhang Menghui, Pang Xiaoyan, Zhang Xiaojun, Zhao Liping · 2015

Accumulating evidence suggests that the gut microbiota is an important factor in mediating the development of obesity-related metabolic disorders, including type 2 diabetes. Metformin and berberine, t…

Personalized Nutrition by Prediction of Glycemic Responses.

Zeevi D, et al. · 2015

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited eff…

Potential overtreatment of diabetes mellitus in older adults with tight glycemic control.

Lipska KJ, et al. · 2015

IMPORTANCE: In older adults with multiple serious comorbidities and functional limitations, the harms of intensive glycemic control likely exceed the benefits. OBJECTIVES: To examine glycemic control …

Serum cotinine levels and diabetes mellitus in never smokers.

Alshaarawy O, Elbaz HA · 2015

OBJECTIVE: The aim of the current study is to examine the association of environmental tobacco smoke (ETS) exposure evident by serum cotinine level, and diabetes mellitus in never smokers. Previous st…

Shift work and endocrine disorders.

Ulhôa MA, et al. · 2015

The objective of this review was to investigate the impact of shift and night work on metabolic processes and the role of alterations in the sleep-wake cycle and feeding times and environmental change…

Short-chain fatty acids in control of body weight and insulin sensitivity.

Canfora EE, et al. · 2015

The connection between the gut microbiota and the aetiology of obesity and cardiometabolic disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the cardiometabolic…

Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise.

Goncalves RL, et al. · 2015

The sites and rates of mitochondrial production of superoxide and H2O2 in vivo are not yet defined. At least 10 different mitochondrial sites can generate these species. Each site has a different maxi…

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Insel RA, et al. · 2015

Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but pre…

The Effect of 8 Weeks Aerobic Exercise on Insulin Resistance in Type 2 Diabetes: A Randomized Clinical Trial

Motahari-Tabari Narges, Shirvani Marjan Ahmad, Shirzad-e-Ahoodashty Mahbobeh, Yousefi-Abdolmaleki Elham, Teimourzadeh Mojgan · 2015

Diabetes complications are the main reasons behind morbidity and mortality preventable by healthy diet and physical activity. There are few studies about the effect of aerobic exercises on insulin res…

The Effects of Leucine, Zinc, and Chromium Supplements on Inflammatory Events of the Respiratory System in Type 2 Diabetic Rats

Kolahian Saeed, Sadri Hassan, Shahbazfar Amir Ali, Amani Morvarid, Mazadeh Anis, Mirani Mehdi · 2015

Diabetes mellitus is a major cause of serious micro- and macrovascular diseases that affect nearly every system in the body, including the respiratory system. Non-enzymatic protein glycation due to hy…

The Relationship Between Food Insecurity and Depression, Diabetes Distress and Medication Adherence Among Low-Income Patients with Poorly-Controlled Diabetes.

Silverman J, et al. · 2015

BACKGROUND: Food insecurity- lack of dependable access to adequate food-may play a role in poor diabetes control. OBJECTIVE: We aimed to determine the relationship between food security status and dep…

The Role of Gluten in Celiac Disease and Type 1 Diabetes

Serena Gloria, Camhi Stephanie, Sturgeon Craig, Yan Shu, Fasano Alessio · 2015

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator o…

The effect of alcohol consumption on insulin sensitivity and glycemic status: a systematic review and meta-analysis of intervention studies.

Schrieks IC, et al. · 2015

OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but resu…

The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review.

English E, et al. · 2015

AIMS/HYPOTHESIS: The use of HbA1c for the diagnosis of diabetes is now widely advocated despite caveats to its use. Anaemia is cited as a major confounder to this use; however, the effect of erythrocy…

Type 2 Diabetic Rats on Diet Supplemented With Chromium Malate Show Improved Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism

Feng Weiwei, Zhao Ting, Mao Guanghua, Wang Wei, Feng Yun, Li Fang, Zheng Daheng, Wu Huiyu et al. · 2015

Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the effect of chromium malate …

Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies.

Tsilidis KK, et al. · 2015

OBJECTIVES: To summarise the evidence and evaluate the validity of the associations between type 2 diabetes and the risk of developing or dying from cancer. DESIGN: An umbrella review of the evidence …

A Randomized Pilot Trial of a Moderate Carbohydrate Diet Compared to a Very Low Carbohydrate Diet in Overweight or Obese Individuals with Type 2 Diabetes Mellitus or Prediabetes

Saslow Laura R., Kim Sarah, Daubenmier Jennifer J., Moskowitz Judith T., Phinney Stephen D., Goldman Veronica, Murphy Elizabeth J., Cox Rachel M. et al. · 2014

We compared the effects of two diets on glycated hemoglobin (HbA1c) and other health-related outcomes in overweight or obese adults with type 2 diabetes or prediabetes (HbA1c>6%). We randomized partic…

Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers.

Beejmohun V, Peytavy-Izard M, Mignon C, Muscente-Paque D, Deplanque X, Ripoll C, Chapal N · 2014

BACKGROUND: Postprandial hyperglycemia is a known risk factor for the development of several health disorders including type 2 diabetes, obesity, oxidative stress, and cardiovascular diseases. One enc…

Added sugar intake and cardiovascular diseases mortality among US adults.

Yang Q, et al. · 2014

IMPORTANCE Epidemiologic studies have suggested that higher intake of added sugar is associated with cardiovascular disease (CVD) risk factors. Few prospective studies have examined the association of…

Artificial sweeteners induce glucose intolerance by altering the gut microbiota.

Suez J, et al. · 2014

Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and benefici…

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation

Xu Miao, Xiao Yuanyuan, Yin Jun, Hou Wolin, Yu Xueying, Shen Li, Liu Fang, Wei Li et al. · 2014

Berberine is a plant alkaloid with anti-diabetic action. Activation of AMP-activated protein kinase (AMPK) pathway has been proposed as mechanism for berberine’s action. This study aimed to examine wh…

Big breakfast rich in protein and fat improves glycemic control in type 2 diabetics.

Rabinovitz HR, et al. · 2014

OBJECTIVE: Our goal was to evaluate the effect of breakfast size and composition on body weight, glycemic control, and metabolic markers in adults with type 2 diabetes mellitus (T2DM). METHODS: 59 ove…

Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis.

Ding M, et al. · 2014

OBJECTIVE: Previous meta-analyses identified an inverse association of coffee consumption with the risk of type 2 diabetes. However, an updated meta-analysis is needed because new studies comparing th…

Collaborative care for comorbid depression and diabetes: a systematic review and meta-analysis.

Atlantis E, et al. · 2014

OBJECTIVE: The collaborative care model is recommended for depression in adults with a chronic physical health problem like diabetes. We sought to systematically assess the effect of collaborative car…

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

Tuttle Katherine R., Bakris George L., Bilous Rudolf W., Chiang Jane L., de Boer Ian H., Goldstein-Fuchs Jordi, Hirsch Irl B., Kalantar-Zadeh Kamyar et al. · 2014

The incidence and prevalence of diabetes mellitus have grown significantly throughout the world, due primarily to the increase in type 2 diabetes. This overall increase in the number of people with di…

Effect of a 6-month vegan low-carbohydrate ('Eco-Atkins') diet on cardiovascular risk factors and body weight in hyperlipidaemic adults: a randomised controlled trial.

Jenkins DJ, et al. · 2014

OBJECTIVE: Low-carbohydrate diets may be useful for weight loss. Diets high in vegetable proteins and oils may reduce the risk of coronary heart disease. The main objective was to determine the longer…

Effect of eating vegetables before carbohydrates on glucose excursions in patients with type 2 diabetes.

Imai S, et al. · 2014

The aim of this review was to evaluate whether eating vegetables before carbohydrates could reduce the postprandial glucose, insulin, and improve long-term glycemic control in Japanese patients with t…

Efficacy of carbohydrate counting in type 1 diabetes: a systematic review and meta-analysis.

Bell KJ, et al. · 2014

BACKGROUND: Although carbohydrate counting is the recommended dietary strategy for achieving glycaemic control in people with type 1 diabetes, the advice is based on narrative review and grading of th…

Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.

Xu R, et al. · 2014

Observational studies have revealed that higher serum vitamin E concentrations and increased vitamin E intake and vitamin E supplementation are associated with beneficial effects on glycaemic control …

Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.

Nyberg ST, et al. · 2014

OBJECTIVE: The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle fact…

Low carbohydrate diet from plant or animal sources and mortality among myocardial infarction survivors.

Li S, et al. · 2014

BACKGROUND: The healthiest dietary pattern for myocardial infarction (MI) survivors is not known. Specific long-term benefits of a low-carbohydrate diet (LCD) are unknown, whether from animal or veget…

Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

Hu Yueshan, Young Alan J., Ehli Erik A., Nowotny Dustin, Davies Paige S., Droke Elizabeth A., Soundy Timothy J., Davies Gareth E. · 2014

Olanzapine is a first line medication for the treatment of schizophrenia, but it is also one of the atypical antipsychotics carrying the highest risk of weight gain. Metformin was reported to produce …

Mindfulness-based cognitive therapy for people with diabetes and emotional problems: long-term follow-up findings from the DiaMind randomized controlled trial.

van Son J, et al. · 2014

OBJECTIVE: The DiaMind trial showed beneficial immediate effects of mindfulness-based cognitive therapy (MBCT) on emotional distress, but not on diabetes distress and HbA1c. The aim of the present rep…

Personality and risk of diabetes in adults: pooled analysis of 5 cohort studies.

Jokela M, et al. · 2014

OBJECTIVE: Diabetes is an increasingly important public health concern, but little is known about the contribution of psychological factors on diabetes risk. We examined whether personality is associa…

Shift work and diabetes--a systematic review.

Knutsson A, et al. · 2014

Diabetes mellitus is a chronic disease, which has an increasing trend all over the world. Type 2 diabetes constitutes 90% of all diabetes. It is associated with weight gain and insulin resistance. Res…

Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release.

Kaji I, et al. · 2014

BACKGROUND: Gut microbiota affects host homeostasis and dysbiosis causes host diseases. Therefore, uncovering the sensing mechanism of bacterial metabolites such as short-chain fatty acid (SCFA) may h…

Smoking cessation and the risk of diabetes mellitus and impaired fasting glucose: three-year outcomes after a quit attempt.

Stein JH, Asthana A, Smith SS, Piper ME, Loh WY, Fiore MC, Baker TB · 2014

UNLABELLED: Weight gain after smoking cessation may increase diabetes mellitus and impaired fasting glucose (IFG) risk. This study evaluated associations between smoking cessation and continued smokin…

Smoking cessation in adults with diabetes: a systematic review and meta-analysis of data from randomised controlled trials.

Nagrebetsky A, et al. · 2014

OBJECTIVES: To evaluate the effects of more intensive smoking cessation interventions compared to less intensive interventions on smoking cessation in people with type 1 or type 2 diabetes. DESIGN: A …

Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment.

Hwang JL, et al. · 2014

Since the advent of glucocorticoid therapy for autoimmune disease in the 1940s, their widespread application has led to the concurrent therapy-limiting discovery of many adverse metabolic side effects…

Supplementary Chromium(III) Propionate Complex Does Not Protect Against Insulin Resistance in High-Fat-Fed Rats

Król Ewelina, Krejpcio Zbigniew, Iwanik Katarzyna · 2014

Improper eating habits such as high-fat or high-carbohydrate diets are responsible for metabolic changes resulting in impaired glucose tolerance, hyperinsulinemia, insulin resistance, and ultimately d…

The psychosocial impact associated with diabetes-related amputation.

McDonald S, et al. · 2014

AIMS: Research has suggested that the additional impact of a diabetes-related amputation is associated with poorer physical functioning, poorer psychosocial outcome and greater body image disturbance.…

Transfer from pediatric to adult health care: effects on diabetes outcomes.

Lyons SK, et al. · 2014

The transfer from pediatric to adult diabetes health care for emerging adults with type 1 diabetes (T1D) has received increasing attention in the literature. This review analyzes the effect of this he…

miR-375 and miR-30d in the Effect of Chromium-Containing Chinese Medicine Moderating Glucose Metabolism

Zhang Qian, Xiao Xinhua, Li Ming, Li Wenhui, Yu Miao, Zhang Huabing, Ping Fan, Wang Zhixin et al. · 2014

In China, TianMai Xiaoke tablet (TM) is used to treat type 2 diabetes. However, the exact mechanism of TM is not clear. This study is to investigate the effect of TM on glucose metabolism in diabetic …

"Turn it off!": diabetes device alarm fatigue considerations for the present and the future.

Shivers JP, et al. · 2013

Safe and widespread use of diabetes technology is constrained by alarm fatigue: when someone receives so many alarms that he or she becomes less likely to respond appropriately. Alarm fatigue and rela…

Association of diabetes with anxiety: a systematic review and meta-analysis.

Smith KJ, et al. · 2013

OBJECTIVES: Anxiety has been shown to be associated with poor outcomes in people with diabetes. However, there has been little research which has specifically examined whether diabetes mellitus is ass…

Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of Research.

Hartling L, et al. · 2013

BACKGROUND: Outcomes of treating gestational diabetes mellitus (GDM) are not well-established. PURPOSE: To summarize evidence about the maternal and neonatal benefits and harms of treating GDM. DATA S…

Both dietary protein and fat increase postprandial glucose excursions in children with type 1 diabetes, and the effect is additive.

Smart CE, et al. · 2013

OBJECTIVE: To determine the separate and combined effects of high-protein (HP) and high-fat (HF) meals, with the same carbohydrate content, on postprandial glycemia in children using intensive insulin…

Brewer's Yeast Improves Glycemic Indices in Type 2 Diabetes Mellitus

Hosseinzadeh Payam, Javanbakht Mohammad Hassan, Mostafavi Seyed-Ali, Djalali Mahmoud, Derakhshanian Hoda, Hajianfar Hossein, Bahonar Ahmad, Djazayery Abolghassem · 2013

Brewer's yeast may have beneficial effects on insulin receptors because of itsglucose tolerance factor in diabetic patients. This study was conducted to investigate the effects of brewer's yeast suppl…

Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.

, et al. · 2013

BACKGROUND: Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. We exam…

Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

Chapple IL, et al. · 2013

BACKGROUND: Diabetes and periodontitis are complex chronic diseases with an established bidirectional relationship. There is long-established evidence that hyperglycaemia in diabetes is associated wit…

Dietary Omega-3 Fatty Acid Deficiency and High Fructose intake in the Development of Metabolic Syndrome Brain, Metabolic Abnormalities, and Non-Alcoholic Fatty Liver Disease

Simopoulos Artemis P. · 2013

Western diets are characterized by both dietary omega-3 fatty acid deficiency and increased fructose intake. The latter found in high amounts in added sugars such as sucrose and high fructose corn syr…

Exercise Protects against Diet-Induced Insulin Resistance through Downregulation of Protein Kinase Cβ in Mice

Rao Xiaoquan, Zhong Jixin, Xu Xiaohua, Jordan Brianna, Maurya Santosh, Braunstein Zachary, Wang Tse-Yao, Huang Wei et al. · 2013

Physical exercise is an important and effective therapy for diabetes. However, its underlying mechanism is not fully understood. Protein kinase Cβ (PKCβ) has been suggested to be involved in the patho…

Exercise, GLUT4, and skeletal muscle glucose uptake.

Richter EA, et al. · 2013

Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose transporter w…

Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies.

Muraki I, et al. · 2013

OBJECTIVE: To determine whether individual fruits are differentially associated with risk of type 2 diabetes. DESIGN: Prospective longitudinal cohort study. SETTING: Health professionals in the United…

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Koeth RA, et al. · 2013

Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstra…

Metabolic surgery, weight regain and diabetes re-emergence.

Campos JM, et al. · 2013

INTRODUCTION: The poor success of clinical treatment of Type 2 Diabetes Mellitus (T2DM2) increased interest in metabolic surgery, which has been considered a promising alternative for the control of o…

Numeracy and dietary intake in patients with type 2 diabetes.

Bowen ME, et al. · 2013

PURPOSE: The purpose of this study is to describe the association between numeracy and self-reported dietary intake in patients with type 2 diabetes. METHODS: Numeracy and dietary intake were assessed…

Nutrition Therapy Recommendations for the Management of Adults With

Evert Alison B., Boucher Jackie L., Cypress Marjorie, Dunbar Stephanie A., Franz Marion J., Mayer-Davis Elizabeth J., Neumiller Joshua J., Nwankwo Robin et al. · 2013

Postprandial reactive hypoglycaemia: varying presentation patterns on extended glucose tolerance tests and possible therapeutic approaches.

Stuart K, et al. · 2013

Reactive hypoglycemia is a state characterised by sympathetic or neuroglycopenic symptoms associated with hypoglycaemia in the postprandial state resulting in considerable distress to the patient. It …

Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts.

White DL, et al. · 2013

There is growing evidence of disordered iron homeostasis in the diabetic condition, with links proposed between dietary iron intakes and both the risk of disease and the risk of complications of advan…

Restoration of self-awareness of hypoglycemia in adults with long-standing type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial.

Leelarathna L, et al. · 2013

OBJECTIVE: Impaired awareness of hypoglycemia (IAH) and defective counterregulation significantly increase severe hypoglycemia risk in type 1 diabetes (T1D). We evaluated restoration of IAH/defective …

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

Ziegler AG, et al. · 2013

IMPORTANCE: Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after seroconversion to islet autoantibodies is unce…

Standards of Medical Care in Diabetes—2013

Autori non disponibili · 2013

Sucralose affects glycemic and hormonal responses to an oral glucose load.

Pepino MY, et al. · 2013

OBJECTIVE: Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We …

The effects of a mindfulness-based intervention on emotional distress, quality of life, and HbA(1c) in outpatients with diabetes (DiaMind): a randomized controlled trial.

van Son J, et al. · 2013

OBJECTIVE: Emotional distress is common in outpatients with diabetes, affecting ∼20-40% of the patients. The aim of this study was to determine the effectiveness of group therapy with Mindfulness-Base…

The high incidence of steroid-induced hyperglycaemia in hospital.

Fong AC, et al. · 2013

AIM: The objective of this study was to systematically evaluate the incidence of steroid-induced hyperglycaemia in a tertiary referral hospital. We conducted a glucometric audit of a prospective proto…

'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials.

Sievenpiper JL, et al. · 2012

Contrary to concerns that fructose may have adverse metabolic effects, there is evidence that small, 'catalytic' doses ( ≤ 10 g/meal) of fructose decrease the glycaemic response to high-glycaemic inde…

A clinical trial to maintain glycemic control in youth with type 2 diabetes.

Zeitler P, et al. · 2012

BACKGROUND: Despite the increasing prevalence of type 2 diabetes in youth, there are few data to guide treatment. We compared the efficacy of three treatment regimens to achieve durable glycemic contr…

Acceptance of insulin therapy: a long shot? Psychological insulin resistance in primary care.

Woudenberg YJ, et al. · 2012

AIM: To explore which factors are associated with psychological insulin resistance in insulin-naive patients with Type 2 diabetes in primary care. METHODS: A sample of 101 insulin-naive patients with …

Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis.

Zhao Z, et al. · 2012

BACKGROUND AND OBJECTIVE: Emerging evidence from biological and epidemiological studies has suggested that body iron stores and heme-iron intake may be related to the risk of type 2 diabetes (T2D). We…

Breaking up prolonged sitting reduces postprandial glucose and insulin responses.

Dunstan DW, et al. · 2012

OBJECTIVE: Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We ex…

Comparison of the effects of a new 32-gauge × 4-mm pen needle and a 32-gauge × 6-mm pen needle on glycemic control, safety, and patient ratings in Japanese adults with diabetes.

Miwa T, et al. · 2012

BACKGROUND: This study was designed to evaluate two pen needles (PNs) with the same diameter but different lengths (4 mm and 6 mm) and different needle tip shapes (straight and tapered) to compare the…

Dietary Fiber, Carbohydrate Quality and Quantity, and Mortality Risk of Individuals with Diabetes Mellitus

Burger Koert N. J., Beulens Joline W. J., van der Schouw Yvonne T., Sluijs Ivonne, Spijkerman Annemieke M. W., Sluik Diewertje, Boeing Heiner, Kaaks Rudolf et al. · 2012

Dietary fiber, carbohydrate quality and quantity are associated with mortality risk in the general population. Whether this is also the case among diabetes patients is unknown. To assess the associati…

Effect of Low Glycemic Load Diet on Glycated Hemoglobin (HbA1c) in Poorly-Controlled Diabetes Patients

Ziaee Amir, Afaghi Ahmad, Sarreshtehdari Majied · 2012

Different carbohydrate diets have been administrated to diabetic patients to evaluate the glycemic response, while Poor-controlled diabetes is increasing world wide. To investigate the role of an alte…

Effects of Combined Dietary Chromium(III) Propionate Complex and Thiamine Supplementation on Insulin Sensitivity, Blood Biochemical Indices, and Mineral Levels in High-Fructose-Fed Rats

Król Ewelina, Krejpcio Zbigniew, Michalak Sławomir, Wójciak Rafał W., Bogdański Paweł · 2012

Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance i…

Global prevalence and major risk factors of diabetic retinopathy.

Yau JW, et al. · 2012

OBJECTIVE: To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METH…

Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine

Chen Xiao-Wu, Di Yuan Ming, Zhang Jian, Zhou Zhi-Wei, Li Chun Guang, Zhou Shu-Feng · 2012

Berberine is one of the main alkaloids found in the Chinese herb Huang lian ( Rhizoma Coptidis ), which has been reported to have multiple pharmacological activities. This study aimed to analyze the m…

Metabolic Effects of Aerobic Training and Resistance Training in Type 2 Diabetic Subjects

Bacchi Elisabetta, Negri Carlo, Zanolin Maria Elisabetta, Milanese Chiara, Faccioli Niccolò, Trombetta Maddalena, Zoppini Giacomo, Cevese Antonio et al. · 2012

To assess differences between the effects of aerobic and resistance training on HbA 1c (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors…

Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects.

Windey K, et al. · 2012

OBJECTIVE: Protein fermentation results in production of metabolites such as ammonia, amines and indolic, phenolic and sulfur-containing compounds. In vitro studies suggest that these metabolites migh…

Psychological experience of parents of children with type 1 diabetes: a systematic mixed-studies review.

Whittemore R, et al. · 2012

PURPOSE: The purpose of this review is to describe the prevalence of psychological distress in parents of children with type 1 diabetes (T1DM), the relationship between parental psychological distress…

Selenium and human health.

Rayman MP · 2012

Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the p…

Standards of Medical Care in Diabetes—2012

Autori non disponibili · 2012

The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences.

Home PD · 2012

Postprandial glucose excursions can inhibit achievement of good glycaemic control, and possibly have a specific effect on the risk of vascular comorbidities. Rapid-acting analogues control these excur…

A Randomized Controlled Trial Investigating the Effects of a Low–Glycemic Index Diet on Pregnancy Outcomes in Gestational Diabetes Mellitus

Louie Jimmy Chun Yu, Markovic Tania P., Perera Nimalie, Foote Deborah, Petocz Peter, Ross Glynis P., Brand-Miller Jennie C. · 2011

The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy over another. We aimed to investigate the effect of a …

A simple meal plan of 'eating vegetables before carbohydrate' was more effective for achieving glycemic control than an exchange-based meal plan in Japanese patients with type 2 diabetes.

Imai S, et al. · 2011

This study aimed to determine whether educating diabetic patients to 'eat vegetables before carbohydrate' was as effective on long-term glycemic control as a traditional exchange-based meal plan. To t…

Adipokines and Body Fat Composition in South Asians: Results of the Metabolic syndrome and Atherosclerosis in South Asians Living in America (MASALA) Study

Shah Arti, Hernandez Alexandra, Mathur Deepika, Budoff Matthew J., Kanaya Alka M. · 2011

To investigate whether leptin and adiponectin are associated with body fat composition in a South Asian population independent of metabolic variables. Cross-sectional study 150 South Asian men and wom…

Drug-induced hypoglycaemia: an update.

Ben Salem C, et al. · 2011

Drugs are the most frequent cause of hypoglycaemia in adults. Although hypoglycaemia is a well known adverse effect of antidiabetic agents, it may occasionally develop in the course of treatment with …

Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast.

Markey O, McClean CM, Medlow P, Davison GW, Trinick TR, Duly E, Shafat A · 2011

BACKGROUND: Cinnamon has been shown to delay gastric emptying of a high-carbohydrate meal and reduce postprandial glycemia in healthy adults. However, it is dietary fat which is implicated in the etio…

Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies.

Yeung WC, et al. · 2011

OBJECTIVE: To review the association between current enterovirus infection diagnosed with molecular testing and development of autoimmunity or type 1 diabetes. DESIGN: Systematic review and meta-analy…

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health.

Russell WR, et al. · 2011

BACKGROUND: Diets that are high in protein but reduced in carbohydrate contents provide a common approach for achieving weight loss in obese humans. However, the effect of such diets on microbiota-der…

Influence of preprandial vs. postprandial insulin glulisine on weight and glycaemic control in patients initiating basal-bolus regimen for type 2 diabetes: a multicenter, randomized, parallel, open-label study (NCT00135096).

Ratner R, et al. · 2011

AIM: Insulin therapy is commonly associated with weight gain. The timing of prandial insulin administration may enhance its efficacy/safety and maintain effective weight control. This study examined t…

Intestinal fructose transport and malabsorption in humans.

Jones HF, et al. · 2011

Fructose is a hexose sugar that is being increasingly consumed in its monosaccharide form. Patients who exhibit fructose malabsorption can present with gastrointestinal symptoms that include chronic d…

Low-carbohydrate diet scores and risk of type 2 diabetes in men.

de Koning L, et al. · 2011

BACKGROUND: Fat and protein sources may influence whether low-carbohydrate diets are associated with type 2 diabetes (T2D). OBJECTIVE: The objective was to compare the associations of 3 low-carbohydra…

Milk A1 and A2 peptides and diabetes.

Clemens RA · 2011

Food-derived peptides, specifically those derived from milk, may adversely affect health by increasing the risk of insulin-dependent diabetes. This position is based on the relationship of type 1 diab…

Modulating gut microbiota as an anti-diabetic mechanism of berberine

Han Junling, Lin Huiling, Huang Weiping · 2011

Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. However, t…

Painful diabetic neuropathy is more than pain alone: examining the role of anxiety and depression as mediators and complicators.

Jain R, et al. · 2011

A wealth of information exists regarding the plight of patients suffering with diabetic peripheral neuropathic pain (DPNP). Although physical pain is certainly a primary challenge in the management of…

Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis.

Umpierre D, et al. · 2011

CONTEXT: Regular exercise improves glucose control in diabetes, but the association of different exercise training interventions on glucose control is unclear. OBJECTIVE: To conduct a systematic revie…

Randomized trial on the influence of the length of two insulin pen needles on glycemic control and patient preference in obese patients with diabetes.

Kreugel G, et al. · 2011

OBJECTIVE: This study determined the influence of needle length for insulin administration on metabolic control and patient preference in obese patients with diabetes mellitus. METHODS: In this multic…

Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.

Salas-Salvadó J, et al. · 2011

OBJECTIVE: To test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. RESEARCH DESIGN AND METHODS: This was a three-arm randomized trial in 4…

Standards of Medical Care in Diabetes—2011

Autori non disponibili · 2011

Brief screening tool for disordered eating in diabetes: internal consistency and external validity in a contemporary sample of pediatric patients with type 1 diabetes.

Markowitz JT, et al. · 2010

OBJECTIVE To update and validate a diabetes-specific screening tool for disordered eating (the Diabetes Eating Problem Survey [DEPS]) in contemporary youth with type 1 diabetes. RESEARCH DESIGN AND ME…

Collaborative care for patients with depression and chronic illnesses.

Katon WJ, et al. · 2010

BACKGROUND: Patients with depression and poorly controlled diabetes, coronary heart disease, or both have an increased risk of adverse outcomes and high health care costs. We conducted a study to dete…

Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males.

Moisey LL, et al. · 2010

Caffeine and caffeinated coffee (CC) elicit acute insulin insensitivity when ingested before a carbohydrate load. The effects of CC on glucose tolerance and insulin sensitivity when co-ingested with a…

Demystifying pleomorphic forms in persistence and expression of disease: Are they bacteria, and is peptidoglycan the solution?

Domingue GJ · 2010

There is considerable circumstantial evidence linking tissue pleomorphic forms of unknown origin with idiopathic chronic inflammatory, collagen, lymphoproliferative, nephro-urological (including inter…

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).

Ristow M, et al. · 2010

Recent evidence suggests that calorie restriction and specifically reduced glucose metabolism induces mitochondrial metabolism to extend life span in various model organisms, including Saccharomyces c…

Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis.

Cappuccio FP, et al. · 2010

OBJECTIVE: To assess the relationship between habitual sleep disturbances and the incidence of type 2 diabetes and to obtain an estimate of the risk. RESEARCH DESIGN AND METHODS: We conducted a system…

Self-efficacy links health literacy and numeracy to glycemic control.

Osborn CY, et al. · 2010

The mechanisms underlying the relationship between health literacy, numeracy, and glycemic control are unclear. We explored the role of diabetes self-efficacy in the predicted pathway linking health l…

Vinegar decreases postprandial hyperglycemia in patients with type 1 diabetes.

Mitrou P, et al. · 2010

Antioxidants prevent health-promoting effects of physical exercise in humans.

Ristow M, et al. · 2009

Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS…

Diabetes numeracy: an overlooked factor in understanding racial disparities in glycemic control.

Osborn CY, et al. · 2009

OBJECTIVE: Understanding the reasons and eliminating the pervasive health disparities in diabetes is a major research, clinical, and health policy goal. We examined whether health literacy, general nu…

Diabetes-specific family conflict and psychological distress in paediatric Type 1 diabetes.

Williams LB, et al. · 2009

AIMS: Diabetes-specific family conflict is associated with suboptimal adherence and glycaemic control. Little is known about the individual and family factors associated with diabetes-specific family …

Effect of non-oil-seed pulses on glycaemic control: a systematic review and meta-analysis of randomised controlled experimental trials in people with and without diabetes.

Sievenpiper JL, et al. · 2009

AIMS/HYPOTHESIS: Dietary non-oil-seed pulses (chickpeas, beans, peas, lentils, etc.) are a good source of slowly digestible carbohydrate, fibre and vegetable protein and a valuable means of lowering t…

Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes.

Ma J, et al. · 2009

OBJECTIVE: We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH DESIGN AND METHODS: Eight type…

Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial.

Song Y, et al. · 2009

BACKGROUND: Vitamin C, vitamin E, and beta-carotene are major antioxidants and as such may protect against the development of type 2 diabetes via reduction of oxidative stress. OBJECTIVE: The purpose …

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

Ichimura A, et al. · 2009

Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). These fatty acid receptors are proposed to pla…

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.

Alberti KG, et al. · 2009

A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors i…

Measurement of short-chain carbohydrates in common Australian vegetables and fruits by high-performance liquid chromatography (HPLC).

Muir JG, et al. · 2009

Fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) are short-chain carbohydrates that can be poorly absorbed by the small intestine and may have a wide range of effects on gastrointest…

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.

Anderson EJ, et al. · 2009

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative …

The Relationship Between Serum Adiponectin, Tumor Necrosis Factor−Alpha, Leptin Levels and Insulin Sensitivity in Childhood and Adolescent Obesity: Adiponectin is a Marker of Metabolic Syndrome

Alikaşifoğlu Ayfer, Gönç E. Nazlı, Özön Z. Alev, Şen Yaşar, Kandemir Nurgün · 2009

Objective : This study aimed (a) to investigate the relationship between the degree of obesity and serum adiponectin, tumor necrosis factor (TNF)−α, leptin, insulin levels and the lipid profile; (b) t…

The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects.

Jenkins DJ, et al. · 2009

BACKGROUND: Low-carbohydrate, high-animal protein diets, which are advocated for weight loss, may not promote the desired reduction in low-density lipoprotein cholesterol (LDL-C) concentration. The ef…

The second-meal phenomenon in type 2 diabetes.

Jovanovic A, et al. · 2009

OBJECTIVE: In health, the rise in glucose after lunch is less if breakfast is eaten. We evaluated the second-meal effect in type 2 diabetes. RESEARCH DESIGN AND METHODS: Metabolic changes after lunch …

10-year follow-up of intensive glucose control in type 2 diabetes.

Holman RR, et al. · 2008

BACKGROUND: During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications …

Depression and type 2 diabetes over the lifespan: a meta-analysis.

Mezuk B, et al. · 2008

OBJECTIVE: It has been argued that the relationship between depression and diabetes is bi-directional, but this hypothesis has not been explicitly tested. This systematic review examines the bi-direct…

Effects of intensive glucose lowering in type 2 diabetes.

, et al. · 2008

BACKGROUND: Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy to …

Italian standards for diabetes mellitus 2007: executive summary

De Micheli Alberto · 2008

Low-carbohydrate-diet score and risk of type 2 diabetes in women.

Halton TL, et al. · 2008

BACKGROUND: Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known. OBJECTIVE: The objective was to examine the association between low-carbohyd…

Parental anxiety and depression associated with caring for a child newly diagnosed with type 1 diabetes: opportunities for education and counseling.

Streisand R, et al. · 2008

OBJECTIVE: To examine demographic and clinical characteristics, such as pediatric parenting stress and self-efficacy for diabetes care, of parents of children newly diagnosed with type 1 diabetes that…

Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

Shai I, et al. · 2008

BACKGROUND: Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates. METHODS: In this 2-year trial, we randomly assign…

Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study.

Hlebowicz J, et al. · 2007

BACKGROUND: Previous studies on healthy people show that vinegar delays gastric emptying and lowers postprandial blood glucose and insulin levels. The aim of this study was to investigate the effect o…

Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial.

Sigal RJ, et al. · 2007

BACKGROUND: Previous trials have evaluated the effects of aerobic training alone and of resistance training alone on glycemic control in type 2 diabetes, as assessed by hemoglobin A1c values. However,…

Polymorphism of bovine beta-casein and its potential effect on human health.

Kamiński S, et al. · 2007

Proteins in bovine milk are a common source of bioactive peptides. The peptides are released by the digestion of caseins and whey proteins. In vitro the bioactive peptide beta-casomorphin 7 (BCM-7) is…

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

Kahn SE, et al. · 2006

BACKGROUND: The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known. METHODS: We evaluat…

Low-carbohydrate-diet score and the risk of coronary heart disease in women.

Halton TL, et al. · 2006

BACKGROUND: Low-carbohydrate diets have been advocated for weight loss and to prevent obesity, but the long-term safety of these diets has not been determined. METHODS: We evaluated data on 82,802 wom…

Reactive oxygen species have a causal role in multiple forms of insulin resistance.

Houstis N, et al. · 2006

Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings. Little is known about why insulin resistance occurs in so…

Social consumption of alcohol in adolescents with Type 1 diabetes is associated with increased glucose lability, but not hypoglycaemia.

Ismail D, et al. · 2006

AIM: To determine the effects of social consumption of alcohol by diabetic adolescents on glycaemic control. METHODS: Fourteen (five male) patients aged > 16 years were recruited from the diabetes cli…

Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme.

Pacher P, et al. · 2005

Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase …

Diabetes mellitus and alcohol.

van de Wiel A · 2004

Alcohol influences glucose metabolism in several ways in diabetic patients as well as in non-diabetic patients. Since alcohol inhibits both gluconeogenesis and glycogenolysis, its acute intake without…

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Petersen KF, et al. · 2004

BACKGROUND: Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown. METHODS: We p…

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.

Taheri S, et al. · 2004

BACKGROUND: Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large …

Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies.

Ziegler AG, et al. · 2003

CONTEXT: Dietary factors modifying type 1 diabetes mellitus (DM) risk have been proposed, but little is known if they trigger the islet autoimmunity that precedes clinical disease. OBJECTIVE: To deter…

Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes.

· 2003

Registered dieticians experienced in developing nutrition therapy for diabetes management have an important role to play in providing medical nutrition therapy. This article provides specific recommen…

American Diabetes Association position statement: evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications.

· 2002

Medical nutrition therapy for people with diabetes should be individualized, with consideration given to the individual's usual food and eating habits, metabolic profile, treatment goals and desired o…

Association of health literacy with diabetes outcomes.

Schillinger D, et al. · 2002

CONTEXT: Health literacy is a measure of patients' ability to read, comprehend, and act on medical instructions. Poor health literacy is common among racial and ethnic minorities, elderly persons, and…

Effect of white versus red meat on endogenous N-nitrosation in the human colon and further evidence of a dose response.

Bingham SA, et al. · 2002

N-nitroso compounds are found in the colon and are formed endogenously because amines and amides are produced by bacterial decarboxylation of amino acids in the large gut. They can be N-nitrosated in …

Fructose prefeeding reduces the glycemic response to a high-glycemic index, starchy food in humans.

Heacock PM, et al. · 2002

The study objective was to determine whether a small dose of fructose administered before or simultaneously with a high glycemic index, starchy food decreases postprandial glycemic response. Nondiabet…

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

Knowler WC, et al. · 2002

BACKGROUND: Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose loa…

Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes.

Moore MC, et al. · 2001

OBJECTIVE: In normal adults, a small (catalytic) dose of fructose administered with glucose decreases the glycemic response to a glucose load, especially in those with the poorest glucose tolerance. W…

Association of depression and diabetes complications: a meta-analysis.

de Groot M, et al. · 2001

OBJECTIVE: The objective of this study was to examine the strength and consistency of the relationship between depression and diabetes complications in studies of type 1 and type 2 adult patients with…

Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study.

Hyppönen E, et al. · 2001

BACKGROUND: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy …

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.

Tuomilehto J, et al. · 2001

BACKGROUND: Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be prevented by interven…

Similar weight loss with low-energy food combining or balanced diets.

Golay A, et al. · 2000

OBJECTIVE: The goal of this study was to evaluate the effect of two diets ('food combining' or dissociated vs balanced) on body weight and metabolic parameters during a 6-week period in an in-hospital…

The effect of calcium on iron absorption.

Lynch SR · 2000

The experimental and epidemiological evidence demonstrating that Ca inhibits Fe absorption was reviewed, with the objectives of estimating the potential impact of variations in Ca intake on dietary Fe…

Gas production in human ingesting a soybean flour derived from beans naturally low in oligosaccharides.

Suarez FL, et al. · 1999

BACKGROUND: Ingestion of soy products may cause excessive intestinal gas. This gas results from colonic bacterial fermentation of the indigestible oligosaccharides raffinose and stachyose, which are p…

Natural engineering principles of electron tunnelling in biological oxidation-reduction.

Page CC, et al. · 1999

We have surveyed proteins with known atomic structure whose function involves electron transfer; in these, electrons can travel up to 14 A between redox centres through the protein medium. Transfer ov…

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

· 1998

BACKGROUND: Improved blood-glucose control decreases the progression of diabetic microvascular disease, but the effect on macrovascular complications is unknown. There is concern that sulphonylureas m…

Lower glycemic response to sucrose in the diets of children with type 1 diabetes.

Rickard KA, et al. · 1998

OBJECTIVE: To compare glycemic responses of isocaloric mixed meals containing 2% and 17% sucrose in children with type 1 diabetes who had fasting euglycemia. STUDY DESIGN: Nine children (11 to 16 year…

Slow and fast dietary proteins differently modulate postprandial protein accretion.

Boirie Y, et al. · 1997

The speed of absorption of dietary amino acids by the gut varies according to the type of ingested dietary protein. This could affect postprandial protein synthesis, breakdown, and deposition. To test…

Practice guidelines for medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus. International Diabetes Center.

Monk A, et al. · 1995

Nutrition practice guidelines define a systematic approach for medical nutrition therapy (MNT) provided by dietitians and are derived from scientific evidence and expert opinion. Nutrition practice gu…

Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group.

· 1994

The Diabetes Control and Complications Trial has demonstrated that intensive diabetes treatment delays the onset and slows the progression of diabetic complications in subjects with insulin-dependent …

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

, et al. · 1993

BACKGROUND: Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatmen…

Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH.

Rosenblum JL, et al. · 1988

Salivary-type amylase may significantly contribute to duodenal starch hydrolysis in exocrine pancreatic insufficiency, provided that gastric inactivation does not occur. We investigated the effect of …

Diabetes Control and Complications Trial (DCCT): results of feasibility study. The DCCT Research Group.

· 1987

The Diabetes Control and Complications Trial (DCCT) is a multicenter, randomized, clinical study designed to determine whether an intensive treatment regimen directed at maintaining blood glucose conc…

Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes.

Amiel SA, et al. · 1986

Patients with insulin-dependent diabetes mellitus often have poor metabolic control during puberty. To determine whether puberty is associated with decreased insulin-stimulated glucose metabolism, we …

Sucrose taken during mixed meal has no additional hyperglycaemic action over isocaloric amounts of starch in well-controlled diabetics.

Slama G, et al. · 1984

The hyperglycaemic effect of 20 g sucrose taken at the end of a regular mixed meal by diabetic patients was measured in six adult type 1 diabetics, C-peptide negative, controlled by the artificial pan…